研究成果
2026年
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Structural and biochemical characterization of a GH5_22 enzyme from the seaweed-derived thermophile Geobacillus thermodenitrificans OS27
Wonkyu Lee, Tomoya Hino, Kenta Fujii, Sugue Tanimoto, Reno Naka, Koya Hara, Takaki Okamoto, Fumiyoshi Okazaki, Shingo Nagano, Takashi Ohshiro, Hirokazu Suzuki
Archives of Biochemistry and Biophysics
2026-04
DOI:
10.1016/j.abb.2026.110736
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The neuropeptide receptor-22, expressed in the intestine, regulates larval development by modulating the production and secretion of insulin-like peptide INS-35 in Caenorhabditis elegans
Sho Maega, Riko Uegaki, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Tsuyoshi Kawano
Biochemical and Biophysical Research Communications 808
2026-04
DOI:
10.1016/j.bbrc.2026.153401
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Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries.
Haochen Tu, Aoi Hosaka, Genki Hichiwa, Yayan Wang, Kanako Kazuki, Toshiaki Tabata, Mitsuhiko Osaki, Yuji Nakayama, Iori Kanazawa, Kazuhisa Honma, Makoto T Kimura, Xu Gao, Norichika Ogata, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki
Stem cell research & therapy
2026-03-20
DOI:
10.1186/s13287-026-04977-8
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UFD1 Recognition of Initiator and Proximal Ubiquitin Drives p97-Mediated Substrate Unfolding enhanced by FAF1, FAF2, and UBXD7
Yusuke Sato, Shunki Miyauchi, Ami Hirano, Nanako Yasumoto, Yuiha Goto, Yoshino Akizuki, Fumika Koyano, Tomoya Hino, Shingo Nagano, Noriyuki Matsuda, Fumiaki Ohtake, Gosuke Hayashi
2026-03-16
DOI:
10.64898/2026.03.13.711538
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Scaling up orphan crop research: genebank genetics highlight geographic structure in cultivated cowpea from 10 617 global accessions
Sofie Pearson, Adrian Hathorn, Shichao Sun, Alan Cruickshank, Tracey Shatte, Paulino Munisse, Mercy Macharia Wairimu, Joann Conner, Anna Koltunow, Jean‐Philippe Vielle‐Calzada, Peggy Ozias‐Akins, Takayoshi Ishii, Matteo Dell'Acqua, Sally Norton, Yongfu Tao, David Jordan, Emma Mace
The Plant Journal 125(6)
2026-03-14
DOI:
10.1111/tpj.70777
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Advances in enzymatic reconstitution of ubiquitin chains and substrate ubiquitination
Yusuke Sato
The Journal of Biochemistry
2026-03-11
DOI:
10.1093/jb/mvaf086
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Crystallization and X-ray structure of a highly aggregation-prone monobody engineered for high-affinity small-molecule recognition
Koushirou Endo, Shun Umemoto, Nariaki Tsuzuki, Hideo Okumura, Yusuke Sato, Tatsuyuki Yoshii, Shinya Tsukiji, Shingo Nagano, Hiroshi Murakami, Tomoya Hino
Acta Crystallographica Section F Structural Biology Communications
2026-03-01
DOI:
10.1107/S2053230X26000798
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Spiral ligament dysfunction and endocochlear potential loss drive hearing impairment in Niemann–Pick C1 mice
Toru Miwa, Yusei Yamada, Akira Ishii, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Hiroki Takeda, Katsumi Higaki, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Brain Research Bulletin
2026-03
DOI:
10.1016/j.brainresbull.2026.111846
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Reconstitution of DNA fragments on HAC/MAC via the fragment-assembly system.
Teruhiko Suzuki, Mana Yamakawa, Shiho Sasaki, Akane Okada, Kanako Kazuki, Satoshi Abe, Seia Nara, Masayuki Su'etsugu, Takahiko Hara, Yasuhiro Kazuki
Scientific reports 16(1)
2026-02-21
DOI:
10.1038/s41598-026-40789-9
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Significant expression of prosaposin in the intermediate lobe of mouse pituitary gland.
Aimi Fuyuki, Masashi Higuchi, Takeshi Homma, Kai Kitamura, Sawa Onouchi, Shouichiro Saito
Cell and tissue research 403(2)
2026-02-16
DOI:
10.1007/s00441-026-04054-9
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Neutral sp2-iminosugars exploiting non-glycone interactions for selective acid α- and β-glucosidase activity modulation: Pharmacological chaperones for Gaucher and Pompe diseases
M. Isabel García-Moreno, Kiyoko Kawakami, Eiji Nanba, José M. García Fernández, Katsumi Higaki, Carmen Ortiz Mellet
European Journal of Medicinal Chemistry 304
2026-02
DOI:
10.1016/j.ejmech.2025.118500
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A genetically encoded microtubule bundler for causal dissection of microtubule bundling in cells
Soei Watari, Takumi Chinen, Yuto Kunitatsu, Takashi Saitou, Yasufumi Takahashi, Kazunori Matsuura, Takanari Inoue, Hiroshi Inaba
bioRxiv
2026-01-23
DOI:
10.64898/2026.01.22.700042
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Rapid immunization and antibody redesign platform discovers broadly neutralizing antibodies against non-immunized SARS-CoV-2 variant.
Shusei Hamamichi, Narumi Uno, Kazuto Shimoya, Takato Fukushima, Marina Abe, Arata Watanabe, Mizuho Ito, Yuko Wakasa, Yuko Yajima, Rio Suzuki, Natsumi Miyazaki, Akifumi Kamiyama, Kana Uno, Masaharu Hiratsuka, Takashi Moriwaki, Tomokazu Tamura, Kyosuke Kanai, Satoshi Abe, Takasuke Fukuhara, Seiji Kageyama, Masayuki Su'etsugu, Yasuhiro Kazuki, Kazuma Tomizuka
Molecular therapy : the journal of the American Society of Gene Therapy 34(1)
2026-01-07
DOI:
10.1016/j.ymthe.2025.10.020
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SPR interaction analysis of GM3 glycan with the integrin α5β1 head domain.
Hanashima S, Kishi M, Sasaki K, Sato Y, Murata M
Glycoconjugate journal
2026-01-06
DOI:
10.1007/s10719-025-10205-x
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In Vitro Efficacy Testing of TONS504-Based Photodynamic Antimicrobial Chemotherapy (TONS504-PACT) Under a 405-nm Light-Emitting Diode Against Antimicrobial-Resistant Bacteria Causing Canine Keratitis.
Tomoya Furujo, Kazuki Harada, Norihiko Ito, Isao Sakata, Tomohiro Osaki
Veterinary ophthalmology 29(1)
2026-01
DOI:
10.1111/vop.70028
