研究成果
2026年
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Proteasome Inhibitor-Induced Cytotoxic Mechanisms in Canine Pulmonary Adenocarcinoma Cell Lines.
Aika Chijiwa, Sakuya Inanaga, Tomohiro Osaki, Masaya Igase, Takuya Mizuno
Veterinary and comparative oncology 24(3)
2026-09
DOI:
10.1111/vco.70065
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Perfluoroether Peptide-Modified Artificial Viral Capsid for Enhanced Doxorubicin Delivery to Liver Cancer Cells
Avijit Ghosh, Yuka Yamamoto, Mizuki Wada, Yasunari Takaki, Hiroshi Inaba, Kohsuke Aikawa, Yu Ota, Yasuhiro Hirata, Takashi Okazoe, Kazunori Matsuura
ACS Omega
2026-08-12
DOI:
10.1021/acsomega.6c04693
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In vitro evaluation of cytotoxicity of TONS504 and blue light irradiation on porcine corneal epithelial cells.
Tomoya Furujo, Norihiko Ito, Isao Sakata, Tomohiro Osaki
The Journal of veterinary medical science
2026-08-04
DOI:
10.1292/jvms.26-0107
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Production of calf anterior pituitary progenitor cell line for conditional regulation of gonadotroph differentiation.
Chihiro Iwamoto, Ai Oguchi, Suzuka Yoshimoto, Masashi Higuchi
Biology of reproduction
2026-07-31
DOI:
10.1093/biolre/ioag162
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A Researcher's guide to rodent models of Down syndrome: Recent insights and translational perspectives.
Mir A Raza, Andrew Folz, Daniella B Victorino, Zhuo Xing, Xu-Qiao Chen, Xinxin Zuo, Leah K Borden, Marie-Claude Potier, William Mobley, Mara Dierssen, Masaharu Hiratsuka, Yasuhiro Kazuki, Kristy Welshhans, Michelle Maugham-Macan, Antonella Tramutola, Eitan Okun, Roger Reeves, Randall J Roper, Y Eugene Yu, Yann Hérault, Victor L J Tybulewicz, Elizabeth M C Fisher, Aaron Sathyanesan
STAR protocols 7(3)
2026-07-24
DOI:
10.1016/j.xpro.2026.104717
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Evaluation of drug-drug interactions of traditional Japanese medicines (Hochuekkito, Goreisan, and Ninjin'yoeito) in CYP3A-humanised mice.
Mari Hida, Chiharu Sadakane, Mitsue Nishiyama, Akinori Nishi, Genki Minegishi, Satoshi Abe, Kanako Kazuki, Yasuhiro Kazuki, Kaoru Kobayashi
Xenobiotica; the fate of foreign compounds in biological systems 56(7)
2026-07
DOI:
10.1080/00498254.2026.2687119
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Virus-inspired functional spherical biomaterials constructed from high-symmetry biomacromolecules: design and applications
Kazunori Matsuura, Hiroshi Inaba
Chemical Society Reviews
2026-07
DOI:
10.1039/d6cs00383d
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Rapid Detection and Quantification of Sweet Potato Storage Roots Using Ground Penetrating Radar
Mika Tei, Jiaqi Liu, Christopher Gomez, Takayoshi Ishii, Yusaku Uga
Plant Phenomics
2026-07
DOI:
10.1016/j.plaphe.2026.100256
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Epigenetic landscape of synthetic human centromere core regions: CENP-A assembly and euchromatic modifications interdependently antagonize heterochromatin accumulation.
Junichiro Ohzeki, Akiko Watanabe, Jia Xian Lee, Chiharu Minami, Kazuto Kugou, Kyotaro Yamazaki, Kenta Shirasawa, Sachiko Isobe, Yusuke Endo, Yasuhiro Kazuki
Nucleic acids research 54(12)
2026-06-22
DOI:
10.1093/nar/gkag597
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Trifluoromethanesulfonamide Induces Male Sterility Through Systemic Metabolic Reprogramming and Anther-Specific Proline Deficiency
Yuka Sekiguchi, Yan Gao, Hiromitsu Tabeta, Muneo Sato, Masami Yokota Hirai, Nasrein Mohamed Kamal, Takayoshi Ishii
International Journal of Molecular Sciences
2026-06-19
DOI:
10.3390/ijms27125554
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CYP3A5 polymorphism affects the disposition of tacrolimus and its metabolite in systemic circulation and peripheral tissues of mice introduced with the CYP3A5 gene.
Genki Minegishi, Yuna Hiramatsu, Manami Sugahara, Satoshi Abe, Kanako Kazuki, Atsushi Miyajima, Yasuhiro Kazuki, Kaoru Kobayashi
Drug metabolism and disposition: the biological fate of chemicals 54(6)
2026-06
DOI:
10.1016/j.dmd.2026.100320
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Establishment and Characterization of Canine Malignant Mesothelioma Cells
Tomohiro Osaki, Taichi Kadohata, Miki Yasunaga, Sohta Hishikawa, Yuji Sunden, Kiwamu Takahashi
Yonago Acta Medica 69(2)
2026-05
DOI:
10.33160/yam.2026.05.007
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Identification of TMEM115 as a tumor suppressor gene and clinical prognostic factor that influences TERT expression in pancreatic cancer.
Yu Sakano, Takahito Ohira, Haruka Ooi, Miyu Murata, Takuki Yagyu, Yuji Nakayama, Tomohiko Sakabe, Teruhisa Sakamoto, Yoshihisa Umekita, Yoshiyuki Fujiwara, Hiroyuki Kugoh
Scientific reports
2026-04-24
DOI:
10.1038/s41598-026-49632-7
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A perforated ovule culture system improves nutrient accessibility and accelerates embryo development in cowpea (Vigna unguiculata (L.) Walp.)
Ngozi Paulinus Ofem, Takayoshi Ishii
Plant Cell, Tissue and Organ Culture (PCTOC) 165(2)
2026-04-16
DOI:
10.1007/s11240-026-03451-w
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Trisomy 8 alters chromatin conformations and activates Y chromosome genes in stem cells to drive a pre-leukemic state
Jie Bai, Kimi Araki, Daisuke Kurotaki, Eerdunduleng, Supannika Sorin, Kei Hiramatsu, Narumi Uno, Ai Hamashima, Mihoko Iimori, Kenta Kikuchi, Minoru Terashima, Sho Kubota, Kensaku Kohrogi, Gang Huang, Minetaro Ogawa, Mitsuo Oshimura, Yasuhiro Kazuki, Goro Sashida
Oncogene
2026-04-04
DOI:
10.1038/s41388-026-03763-3
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Structural and biochemical characterization of a GH5_22 enzyme from the seaweed-derived thermophile Geobacillus thermodenitrificans OS27
Wonkyu Lee, Tomoya Hino, Kenta Fujii, Sugue Tanimoto, Reno Naka, Koya Hara, Takaki Okamoto, Fumiyoshi Okazaki, Shingo Nagano, Takashi Ohshiro, Hirokazu Suzuki
Archives of Biochemistry and Biophysics 778
2026-04
DOI:
10.1016/j.abb.2026.110736
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The neuropeptide receptor-22, expressed in the intestine, regulates larval development by modulating the production and secretion of insulin-like peptide INS-35 in Caenorhabditis elegans
Sho Maega, Riko Uegaki, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Tsuyoshi Kawano
Biochemical and Biophysical Research Communications 808
2026-04
DOI:
10.1016/j.bbrc.2026.153401
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Rejuvenation of mesenchymal stromal cells via partial reprogramming enables scalable generation of transcriptionally diverse MSC libraries.
Haochen Tu, Aoi Hosaka, Genki Hichiwa, Yayan Wang, Kanako Kazuki, Toshiaki Tabata, Mitsuhiko Osaki, Yuji Nakayama, Iori Kanazawa, Kazuhisa Honma, Makoto T Kimura, Xu Gao, Norichika Ogata, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki
Stem cell research & therapy 17(1)
2026-03-20
DOI:
10.1186/s13287-026-04977-8
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UFD1 Recognition of Initiator and Proximal Ubiquitin Drives p97-Mediated Substrate Unfolding enhanced by FAF1, FAF2, and UBXD7
Yusuke Sato, Shunki Miyauchi, Ami Hirano, Nanako Yasumoto, Yuiha Goto, Yoshino Akizuki, Fumika Koyano, Tomoya Hino, Shingo Nagano, Noriyuki Matsuda, Fumiaki Ohtake, Gosuke Hayashi
2026-03-16
DOI:
10.64898/2026.03.13.711538
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Scaling up orphan crop research: genebank genetics highlight geographic structure in cultivated cowpea from 10 617 global accessions
Sofie Pearson, Adrian Hathorn, Shichao Sun, Alan Cruickshank, Tracey Shatte, Paulino Munisse, Mercy Macharia Wairimu, Joann Conner, Anna Koltunow, Jean‐Philippe Vielle‐Calzada, Peggy Ozias‐Akins, Takayoshi Ishii, Matteo Dell'Acqua, Sally Norton, Yongfu Tao, David Jordan, Emma Mace
The Plant Journal 125(6)
2026-03-14
DOI:
10.1111/tpj.70777
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Advances in enzymatic reconstitution of ubiquitin chains and substrate ubiquitination
Yusuke Sato
The Journal of Biochemistry
2026-03-11
DOI:
10.1093/jb/mvaf086
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Crystallization and X-ray structure of a highly aggregation-prone monobody engineered for high-affinity small-molecule recognition
Koushirou Endo, Shun Umemoto, Nariaki Tsuzuki, Hideo Okumura, Yusuke Sato, Tatsuyuki Yoshii, Shinya Tsukiji, Shingo Nagano, Hiroshi Murakami, Tomoya Hino
Acta Crystallographica Section F Structural Biology Communications
2026-03-01
DOI:
10.1107/S2053230X26000798
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Spiral ligament dysfunction and endocochlear potential loss drive hearing impairment in Niemann–Pick C1 mice
Toru Miwa, Yusei Yamada, Akira Ishii, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Hiroki Takeda, Katsumi Higaki, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Brain Research Bulletin
2026-03
DOI:
10.1016/j.brainresbull.2026.111846
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Reconstitution of DNA fragments on HAC/MAC via the fragment-assembly system.
Teruhiko Suzuki, Mana Yamakawa, Shiho Sasaki, Akane Okada, Kanako Kazuki, Satoshi Abe, Seia Nara, Masayuki Su'etsugu, Takahiko Hara, Yasuhiro Kazuki
Scientific reports 16(1)
2026-02-21
DOI:
10.1038/s41598-026-40789-9
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Significant expression of prosaposin in the intermediate lobe of mouse pituitary gland.
Aimi Fuyuki, Masashi Higuchi, Takeshi Homma, Kai Kitamura, Sawa Onouchi, Shouichiro Saito
Cell and tissue research 403(2)
2026-02-16
DOI:
10.1007/s00441-026-04054-9
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Neutral sp2-iminosugars exploiting non-glycone interactions for selective acid α- and β-glucosidase activity modulation: Pharmacological chaperones for Gaucher and Pompe diseases
M. Isabel García-Moreno, Kiyoko Kawakami, Eiji Nanba, José M. García Fernández, Katsumi Higaki, Carmen Ortiz Mellet
European Journal of Medicinal Chemistry 304
2026-02
DOI:
10.1016/j.ejmech.2025.118500
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A genetically encoded microtubule bundler for causal dissection of microtubule bundling in cells
Soei Watari, Takumi Chinen, Yuto Kunitatsu, Takashi Saitou, Yasufumi Takahashi, Kazunori Matsuura, Takanari Inoue, Hiroshi Inaba
bioRxiv
2026-01-23
DOI:
10.64898/2026.01.22.700042
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Rapid immunization and antibody redesign platform discovers broadly neutralizing antibodies against non-immunized SARS-CoV-2 variant.
Shusei Hamamichi, Narumi Uno, Kazuto Shimoya, Takato Fukushima, Marina Abe, Arata Watanabe, Mizuho Ito, Yuko Wakasa, Yuko Yajima, Rio Suzuki, Natsumi Miyazaki, Akifumi Kamiyama, Kana Uno, Masaharu Hiratsuka, Takashi Moriwaki, Tomokazu Tamura, Kyosuke Kanai, Satoshi Abe, Takasuke Fukuhara, Seiji Kageyama, Masayuki Su'etsugu, Yasuhiro Kazuki, Kazuma Tomizuka
Molecular therapy : the journal of the American Society of Gene Therapy 34(1)
2026-01-07
DOI:
10.1016/j.ymthe.2025.10.020
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The FMRFamide-like peptide FLP-11 regulates the production and secretion of the TGF-β-like protein DAF-7 during Caenorhabditis elegans larval development
Riko Uegaki, Sho Maega, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Akira Shiraishi, Honoo Satake, Tsuyoshi Kawano
Scientific Reports 16(1)
2026-01-07
DOI:
10.1038/s41598-025-34917-0
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SPR interaction analysis of GM3 glycan with the integrin α5β1 head domain.
Hanashima S, Kishi M, Sasaki K, Sato Y, Murata M
Glycoconjugate journal
2026-01-06
DOI:
10.1007/s10719-025-10205-x
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In Vitro Efficacy Testing of TONS504-Based Photodynamic Antimicrobial Chemotherapy (TONS504-PACT) Under a 405-nm Light-Emitting Diode Against Antimicrobial-Resistant Bacteria Causing Canine Keratitis.
Tomoya Furujo, Kazuki Harada, Norihiko Ito, Isao Sakata, Tomohiro Osaki
Veterinary ophthalmology 29(1)
2026-01
DOI:
10.1111/vop.70028
