研究成果
2019年
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Bisphosphonate-induced reactive oxygen species inhibit proliferation and migration of oral fibroblast: A pathogenesis of bisphosphonate-related osteonecrosis of the jaw.
Naomi Taniguchi, Mitsuhiko Osaki, Kunishige Onuma, Mizuho Ishikawa, Kazuo Ryoke, Isamu Kodani, Futoshi Okada
Journal of periodontology
2019-12-21
DOI:
10.1002/JPER.19-0385
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Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of α-Synuclein.
Hanae Yamamoto, Naoya Fukui, Mayuka Adachi, Eiichi Saiki, Anna Yamasaki, Rio Matsumura, Daichi Kuroyanagi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
International Journal of Molecular Sciences 21(1)
2019-12-19
DOI:
10.3390/ijms21010047
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Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
Yusuke Sato, Hikaru Tsuchiya, Atsushi Yamagata, Kei Okatsu, Keiji Tanaka, Yasushi Saeki, Shuya Fukai
Nature communications 10(1)
2019-12-13
DOI:
10.1038/s41467-019-13697-y
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Dynamics of host and graft after cell sheet transplantation: Basic study for the application of amyotrophic lateral sclerosis.
Mami Nakanishi, Yasuhiro Watanabe, Naoto Honda, Mio Une, Kanako Kazuki, Yasuhiro Kazuki, Tomoya Terashima, Miwako Katagi, Kenji Nakashima, Ritsuko Hanajima
Brain research 1724
2019-12-01
DOI:
10.1016/j.brainres.2019.146444
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細胞膜透過ペプチド：ポリヒスチジンを利用した動物・植物細胞に対する分子輸送
岩崎 崇
日本農薬学会誌 44
2019-12
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An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells.
Takahito Ohira, Koichi Miyauchi, Narumi Uno, Noriaki Shimizu, Yasuhiro Kazuki, Mitsuo Oshimura, Hiroyuki Kugoh
Scientific reports 9(1)
2019-11-18
DOI:
10.1038/s41598-019-53116-2
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Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo.
Minegishi G, Kazuki Y, Yamasaki Y, Okuya F, Akita H, Oshimura M, Kobayashi K
Xenobiotica; the fate of foreign compounds in biological systems 49(11)
2019-11
DOI:
10.1080/00498254.2018.1560516
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CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.
Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y
Molecular pharmacology 96(5)
2019-11
DOI:
10.1124/mol.119.117333
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Subclinical Epstein-Barr Virus Primary Infection and Lytic Reactivation Induce Thyrotropin Receptor Autoantibodies
Naohiro Tamoto, Keiko Nagata, Sayuri Hara, Yuji Nakayama, Satoshi Kuwamoto, Michiko Matsushita, Masako Kato, Kazuhiko Hayashi
VIRAL IMMUNOLOGY 32(9)
2019-11
DOI:
10.1089/vim.2019.0086
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ヒト腎細胞癌においてリソソーム結合膜タンパク質-2発現はスニチニブ療法耐性に関与しているのか(Is lysosome-associated membrane protein-2 expression involved in sunitinib resistance in human renal cell carcinoma?)
西川 涼馬, 尾崎 充彦, 佐々木 諒, 弓岡 徹也, 山口 徳也, 岩本 秀人, 森實 修一, 本田 正史, 岡田 太, 武中 篤
西日本泌尿器科 81(増刊)
2019-10
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CRISPR/Cas9-based RGEN-ISL allows the simultaneous and specific visualization of proteins, DNA repeats, and sites of DNA replication
Takayoshi Ishii
Cytogenetic and Genome Research 159 (1), 48-53 (159)
2019-10
DOI:
10.1159/000502600
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Increased regulatory B cells are involved in immune evasion in patients with gastric cancer
Yuki Murakami, Hiroaki Saito, Shota Shimizu, Yusuke Kono, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Keigo Ashida, Tomohiko Sakabe, Yuji Nakayama, Yoshiyuki Fujiwara
SCIENTIFIC REPORTS 9
2019-09
DOI:
10.1038/s41598-019-49581-4
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Of floral fortune: tinkering with the grain yield potential of cereal crops.
Sakuma S, Schnurbusch T
The New phytologist
2019-09
DOI:
10.1111/nph.16189
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Development of Organelle Replacement Therapy Using a Stearyl-Polyhistidine Peptide against Lysosomal Storage Disease Cells
Hayashi, Okamoto, Kawano, Iwasaki
Molecules 24(16)
2019-08-18
DOI:
10.3390/molecules24162995
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Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.
Mito Kanatsu-Shinohara, Takuya Yamamoto, Hidehiro Toh, Yasuhiro Kazuki, Kanako Kazuki, Junichi Imoto, Kazuho Ikeo, Motohiko Oshima, Katsuhiko Shirahige, Atsushi Iwama, Yoichi Nabeshima, Hiroyuki Sasaki, Takashi Shinohara
Proceedings of the National Academy of Sciences of the United States of America 116(33)
2019-08-13
DOI:
10.1073/pnas.1904980116
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Synthesis and biological evaluation of glucose conjugated phthalocyanine as a second-generation photosensitizer.
Yoshiyuki Uruma, Loghapriya Sivasamy, Priscilla Mei Yen Yoong, Kunishige Onuma, Yuto Omura, Matsumi Doe, Mitsuhiko Osaki, Futoshi Okada
Bioorganic & medicinal chemistry 27(15)
2019-08-01
DOI:
10.1016/j.bmc.2019.06.005
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High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves' Disease Patients and Healthy Controls
Sayuri Hara, Keiko Nagata, Yuji Nakayama, Katsumi Higaki, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Kazuhiko Hayashi
YONAGO ACTA MEDICA 62(2)
2019-06
DOI:
10.33160/yam.2019.06.010
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Fluorescent Tau-derived Peptide for Monitoring Microtubules in Living Cells
Hiroshi Inaba, Takahisa Yamamoto, Takashi Iwasaki, Arif Md, Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
ACS Omega 4(6)
2019-06
DOI:
10.1021/acsomega.9b01089
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Stabilization of microtubules by encapsulation of the GFP using a Tau-derived peptide
Hiroshi Inaba, Takahisa Yamamoto, Takashi Iwasaki, Arif Md, Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
Chemical Communications 55(62)
2019-06
DOI:
10.1039/c9cc04345d
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Structural insights into a key step of brassinosteroid biosynthesis and its inhibition
Keisuke Fujiyama, Tomoya Hino, Masahiro Kanadani, Bunta Watanabe, Hyoung Jae Lee, Masaharu Mizutani, Shingo Nagano
Nature Plants 5(6)
2019-06
DOI:
10.1038/s41477-019-0436-6
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Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth.
Mizuho Ishikawa, Mitsuhiko Osaki, Makoto Yamagishi, Kunishige Onuma, Hisao Ito, Futoshi Okada, Hideya Endo
Oncogene 38(24)
2019-06
DOI:
10.1038/s41388-019-0748-z
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Exosomes and Their Role in Cancer Progression.
Mitsuhiko Osaki, Futoshi Okada
Yonago acta medica 62(2)
2019-06
DOI:
10.33160/yam.2019.06.002
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De novo formation and epigenetic maintenance of centromere chromatin.
Junichirou Ohzeki, Vladimir Larionov, William C Earnshaw, Hiroshi Masumoto
Current opinion in cell biology 58
2019-06
DOI:
10.1016/j.ceb.2018.12.004
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Stabilization of Microtubules by Encapsulation of GFP Using Tau-Derived Peptide
H. Inaba, T. Yamamoto, T. Iwasaki, A.M.R. Kabir, A. Kakugo, K. Sada, K. Matsuura
Chem. Commun. 55(62)
2019-06
DOI:
10.1039/c9cc04345d
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RNA-guided endonuclease – in situ labelling (RGEN-ISL): a fast CRISPR/Cas9-based method to label genomic sequences in various species
Ishii, T., Schubert, V., Khosravi, S., Dreissig, S., Metje-Sprink, J., Sprink, T., Fuchs, J., Meister, A., Houben, A.
New Phytologist 222(3)
2019-05
DOI:
10.1111/nph.15720
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Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.
Tomio S Takahashi, Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Masafumi Saijo, Shuya Fukai
Nucleic acids research 47(7)
2019-04-23
DOI:
10.1093/nar/gkz081
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MicroRNA-Based Diagnosis and Treatment of Metastatic Human Osteosarcoma.
Ryo Sasaki, Mitsuhiko Osaki, Futoshi Okada
Cancers 11(4)
2019-04-18
DOI:
10.3390/cancers11040553
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認知症の原因となるアミロイド線維形成を抑制するスペアミント由来ロスマリン酸
小川 健二郎, 石井 歩美, 進藤 愛未, 本郷 邦広, 溝端 知宏, 荘厳 哲哉, 河田 康志
日本栄養・食糧学会大会講演要旨集 73回
2019-04
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Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5.
Sakurako Goto-Ito, Nobukatsu Morooka, Atsushi Yamagata, Yusuke Sato, Ken Sato, Shuya Fukai
Life science alliance 2(2)
2019-04
DOI:
10.26508/lsa.201900297
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Possible Relationship Between MYBL1 Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases.
Yukari Endo, Satoshi Kuwamoto, Takahito Ohira, Michiko Matsushita, Takahiro Matsushige, Takahiro Fukuhara, Shu Nakamoto, Kazuhiko Hayashi, Hiroyuki Kugoh, Yasuaki Hirooka
Yonago acta medica 62(1)
2019-03
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Construction of Artificial Viral Capsids Encapsulating Short DNAs via Disulfide Bonds and Controlled Release of DNAs by Reduction
Yoko Nakamura, Hiroshi Inaba, Kazunori Matsuura
Chemistry Letters 48
2019-03
DOI:
10.1246/cl.190091
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Unleashing floret fertility in wheat through the mutation of a homeobox gene.
Sakuma S, Golan G, Guo Z, Ogawa T, Tagiri A, Sugimoto K, Bernhardt N, Brassac J, Mascher M, Hensel G, Ohnishi S, Jinno H, Yamashita Y, Ayalon I, Peleg Z, Schnurbusch T, Komatsuda T
Proceedings of the National Academy of Sciences of the United States of America 116(11)
2019-03
DOI:
10.1073/pnas.1815465116
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Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism
Kazuki, Yasuhiro, Kobayashi, Kaoru, Hirabayashi, Masumi, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Takiguchi, Masato, Satoh, Daisuke, Kuze, Jiro, Sakuma, Tetsushi, Kaneko, Takehito, Mashimo, Tomoji, Osamura, Minori, Hashimoto, Mari, Wakatsuki, Riko, Hirashima, Rika, Fujiwara, Ryoichi, Deguchi, Tsuneo, Kurihara, Atsushi, Tsukazaki, Yasuko, Senda, Naoto, Yamamoto, Takashi, Scheer, Nico, Oshimura, Mitsuo
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 116(8)
2019-02-19
DOI:
10.1073/pnas.1808255116
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Acid-denatured small heat shock protein HdeA from Escherichia coli forms reversible fibrils with an atypical secondary structure.
Shiori Miyawaki, Yumi Uemura, Kunihiro Hongo, Yasushi Kawata, Tomohiro Mizobata
The Journal of biological chemistry 294(5)
2019-02-01
DOI:
10.1074/jbc.RA118.005611
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Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer.
Hiramatsu K, Abe S, Kazuki K, Osaki M, Kajitani N, Yakura Y, Oshimura M, Kazuki Y
Biochem Biophys Res Commun. 508(2)
2019-01
DOI:
10.1016/j.bbrc.2018.11.138.
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PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.
Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Sayaka Aoki, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh
PloS one 14(8)
2019
DOI:
10.1371/journal.pone.0217605
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Multivalent glycolignads with lectin/enzyme dual specificity: self-deliverable glycosidase regulators.
Gonzalez-Cuesta M, Goyard D, Nanba E, Higaki K, Garcia-Fernandez JM, Renaudet O, Mellet CO
ChemComm 55
2019
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GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson’s disease
Ikuno M, Yamakado H, Akiyama H, Parajuli LK, Taguchi K, Hara J, Uemura N, Hatanaka Y, Higaki K, Ohno K, Tanaka M, Koike M, Hirabayashi Y, Takahasi R
Hum Mol Genet 28
2019
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Multipoint enzyme inhibition in a medicinal chemistry cintext: pharmacological chaperones for the treatment of a-Mannosidosis.
Risquez-Cuadro R, Matsumoto R, Caballero FO, Nanba E, Higaki K, Garcia-Fernandez JM, Mellet CO
J Med Chem 62
2019
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The circadian rhythm of bladder clock genes in the spontaneously hypersensitive rat.
Yusuke Kimura, Masashi Honda, Ryo Sasaki, Tetsuya Yumioka, Hideto Iwamoto, Panagiota Tsounapi, Shuichi Morizane, Katsuya Hikita, Mitsuhiko Osaki, Futoshi Okada, Atsushi Takenaka
PloS one 14(7)
2019
DOI:
10.1371/journal.pone.0220381
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Reversal of established liver fibrosis by IC-2-engineered mesenchymal stem cell sheets.
Itaba N, Kono Y, Watanabe K, Yokobata T, Oka H, Osaki M, Kakuta H, Morimoto M, Shiota G
Sci Rep. 9(1)
2019
DOI:
10.1038/s41598-019-43298-0
