研究成果
2012年
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Electrophysiological Properties of Prion-Positive Cardiac Progenitors Derived From Murine Embryonic Stem Cells
Hiroshi Fujii, Yu Ikeuchi, Yasutaka Kurata, Nobuhito Ikeda, Udin Bahrudin, Peili Li, Yuji Nakayama, Ryo Endo, Akira Hasegawa, Kumi Morikawa, Junichiro Miake, Akio Yoshida, Kyoko Hidaka, Takayuki Morisaki, Haruaki Ninomiya, Yasuaki Shirayoshi, Kazuhiro Yamamoto, Ichiro Hisatome
CIRCULATION JOURNAL 76(12)
2012-12
DOI:
10.1253/circj.CJ-12-0126
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StaC型の活性を持つ変異型RebCの結晶構造解析とインドロカルバゾール化合物の分子骨格を作り分けるメカニズム
板谷 颯, 出雲 栄悠, 景山 沙貴, 黒住 彩佳, 尾仲 宏康, 浅水 俊平, 日野 智也, 永野 真吾
日本生化学会大会プログラム・講演要旨集 85回
2012-12
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Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat.
Kobayashi S, Kuwata K, Sugimoto T, Igarashi K, Osaki M, Okada F, Fujii J, Bannai S, Sato H
Free radical biology & medicine 53(12)
2012-12
DOI:
10.1016/j.freeradbiomed.2012.09.040
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Fate of the DNA introduced into culture cells: How does artificial chromosome formation, chromosomal integration or exclusion from nuclei occur?
Hiroshi Masumoto, Jun-ichirou Ohzeki, Megumi Nakano, Vladimir Larionov, William C Earnshaw
2012-12
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Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin.
Wenjing Li, Takashi Moriwaki, Tomomi Tani, Takashi Watanabe, Kozo Kaibuchi, Gohta Goshima
The Journal of cell biology 199(5)
2012-11-26
DOI:
10.1083/jcb.201206101
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Replication timing in a single human chromosome 11 transferred into the Chinese hamster ovary (CHO) cell line
Yoshihisa Watanabe, Yasuhiro Kazuki, Mitsuo Oshimura, Toshimichi Ikemura, Masato Maekawa
GENE 510(1)
2012-11
DOI:
10.1016/j.gene.2012.08.045
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神経疾患iPS細胞の現状と展望 ヒト人工染色体をもちいたデュシャンヌ型筋ジストロフィー遺伝子治療への挑戦
押村 光雄, 香月 康宏, 宇野 愛海
臨床神経学 52(11)
2012-11
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Anti-Angiogenesis Activities of Novel Peptide Complexes: Mitochondria-Disruptive 9mer Peptides Conjugated with the Integrin alpha V beta 3-Homing Cyclic RGD Motif
Takashi Iwasaki, Minoru Yamakawa, Ai Asaoka, Tsuyoshi Kawano, Jun Ishibashi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76(11)
2012-11
DOI:
10.1271/bbb.120397
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A Caenorhabditis elegans Insulin-Like Peptide, INS-17: Its Physiological Function and Expression Pattern
Yohei Matsunaga, Kensuke Nakajima, Keiko Gengyo-Ando, Shohei Mitani, Takashi Iwasaki, Tsuyoshi Kawano
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76(11)
2012-11
DOI:
10.1271/bbb.120540
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Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice
Tomoko Nakanishi, Kazuo Kokubun, Haruka Oda, Mika Aoki, Atsumi Soma, Makoto Taniguchi, Yasuhiro Kazuki, Mitsuo Oshimura, Kenzo Sato
BONE 51(3)
2012-09
DOI:
10.1016/j.bone.2012.06.012
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Role of C-terminal negative charges and tyrosine residues in fibril formation of alpha-synuclein
Yasutaka Izawa, Hironobu Tateno, Hiroshi Kameda, Kazuya Hirakawa, Keiko Hato, Hisashi Yagi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
BRAIN AND BEHAVIOR 2(5)
2012-09
DOI:
10.1002/brb3.86
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Get1 Stabilizes an Open Dimer Conformation of Get3 ATPase by Binding Two Distinct Interfaces
Keiko Kubota, Atsushi Yamagata, Yusuke Sato, Sakurako Goto-Ito, Shuya Fukai
JOURNAL OF MOLECULAR BIOLOGY 422(3)
2012-09
DOI:
10.1016/j.jmb.2012.05.045
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Population-genetic analysis of HvABCG31 promoter sequence in wild barley (Hordeum vulgare ssp spontaneum)
Xiaoying Ma, Hanan Sela, Genlin Jiao, Chao Li, Aidong Wang, Mohammad Pourkheirandish, Dmitry Weiner, Shun Sakuma, Tamar Krugman, Eviatar Nevo, Takao Komatsuda, Abraham Korol, Guoxiong Chen
BMC EVOLUTIONARY BIOLOGY 12(1)
2012-09
DOI:
10.1186/1471-2148-12-188
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Prognostic significance of sirtuin 2 protein nuclear localization in glioma: An immunohistochemical study
Natsuko Imaoka, Masaharu Hiratsuka, Mitsuhiko Osaki, Hideki Kamitani, Atsushi Kambe, Junya Fukuoka, Masanori Kurimoto, Shoichi Nagai, Futoshi Okada, Takashi Watanabe, Eisaku Ohama, Shinsuke Kato, Mitsuo Oshimura
ONCOLOGY REPORTS 28(3)
2012-09
DOI:
10.3892/or.2012.1872
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Telomere fusions in early human breast carcinoma.
Tanaka H, Abe S, Nazmul Huda, Liren Tu, Beam MJ, Grimes B, Gilley D
Proceedings of the National Academy of Sciences of the United States of America
2012-08-13
DOI:
10.1073/pnas.1120062109
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低酸素によるhMSH3の発現抑制と大腸がんにおけるゲノム不安定性(Hypoxic down-regulation of DNA mismatch repair gene hMSH3 and genetic instability of colorectal cancer)
逸見 仁道, 有田 通恒, 小池 淳一, 菊池 由宣, 船橋 公彦, 大平 崇人, 久郷 裕之, 近藤 元就
日本癌学会総会記事 71回
2012-08
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Molecular Dynamics Simulations Reveal Proton Transfer Pathways in Cytochrome C-Dependent Nitric Oxide Reductase
Andrei V. Pisliakov, Tomoya Hino, Yoshitsugu Shiro, Yuji Sugita
PLOS COMPUTATIONAL BIOLOGY 8(8)
2012-08
DOI:
10.1371/journal.pcbi.1002674
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Recruitment of TRF2 to laser-induced DNA damage sites.
Nazmul Huda, Abe S, Gu L, Mendonca MS, Mohanty S, Gilley D
Free radical biology & medicine
2012-07-27
DOI:
10.1016/j.freeradbiomed.2012.07.024
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Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma acidophilum
NOI KENTARO, KITAMURA AYA, HIRAI HIDENORI, HONGO KUNIHIRO, SAKURAI TOSHIHIKO, MIZOBATA TOMOHIRO, KAWATA YASUSHI
American Journal of Molecular Biology 2(3)
2012-07
DOI:
10.4236/ajmb.2012.23028
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Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13
Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Keiko Kubota, Rikako Miyamoto, Shinichiro Nakada, Shuya Fukai
JOURNAL OF BIOLOGICAL CHEMISTRY 287(31)
2012-07
DOI:
10.1074/jbc.M112.364752
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Physiological function, expression pattern, and transcriptional regulation of a Caenorhabditis elegans insulin-like peptide, INS-18
Yohei Matsunaga, Keiko Gengyo-Ando, Shohei Mitani, Takashi Iwasaki, Tsuyoshi Kawano
Biochemical and Biophysical Research Communications 423(3)
2012-07
DOI:
10.1016/j.bbrc.2012.05.145
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Hybridization of Testis-Derived Stem Cells with Somatic Cells and Embryonic Stem Cells in Mice
Masanori Takehashi, Masako Tada, Mito Kanatsu-Shinohara, Hiroko Morimoto, Yasuhiro Kazuki, Mitsuo Oshimura, Takashi Tada, Takashi Shinohara
BIOLOGY OF REPRODUCTION 86(6)
2012-06
DOI:
10.1095/biolreprod.112.098988
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Photodynamic Hyperthermal Therapy with Indocyanine Green (ICG) induces Apoptosis and Cell Cycle Arrest in B16F10 Murine Melanoma Cells
Rozanaliza Radzi, Tomohiro Osaki, Takeshi Tsuka, Tomohiro Imagawa, Saburo Minami, Yuji Nakayama, Yoshiharu Okamoto
JOURNAL OF VETERINARY MEDICAL SCIENCE 74(5)
2012-05
DOI:
10.1292/jvms.11-0464
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Structural basis for nitrous oxide generation by bacterial nitric oxide reductases
Yoshitsugu Shiro, Hiroshi Sugimoto, Takehiko Tosha, Shingo Nagano, Tomoya Hino
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 367(1593)
2012-05
DOI:
10.1098/rstb.2011.0310
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Therapeutic chaperone effect of N-Octyl 4-Epi-beta-valienamine on murine G(M1)-gangliosidosis
Yoshiyuki Suzuki, Satoshi Ichinomiya, Mieko Kurosawa, Junichiro Matsuda, Seiichiro Ogawa, Masami Iida, Takatoshi Kubo, Miho Tabe, Masayuki Itoh, Katsumi Higaki, Eiji Nanba, Kousaku Ohno
MOLECULAR GENETICS AND METABOLISM 106(1)
2012-05
DOI:
10.1016/j.ymgme.2012.02.012
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Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly
Jun-ichirou Ohzeki, Jan H. Bergmann, Natalay Kouprina, Vladimir N. Noskov, Megumi Nakano, Hiroshi Kimura, William C. Earnshaw, Vladimir Larionov, Hiroshi Masumoto
EMBO JOURNAL 31(10)
2012-05
DOI:
10.1038/emboj.2012.82
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Down-regulation of MutS homolog 3 by hypoxia in human colorectal cancer
Jie Li, Junichi Koike, Hiroyuki Kugoh, Michitsune Arita, Takahito Ohhira, Yoshinori Kikuchi, Kimihiko Funahashi, Ken Takamatsu, C. Richard Boland, Minoru Koi, Hiromichi Hemmi
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1823(4)
2012-04
DOI:
10.1016/j.bbamcr.2012.01.017
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Varied effects of Pyrococcus furiosus prefoldin and P-furiosus chaperonin on the refolding reactions of substrate proteins
Kunihiro Hongo, Hiroshi Itai, Tomohiro Mizobata, Yasushi Kawata
JOURNAL OF BIOCHEMISTRY 151(4)
2012-04
DOI:
10.1093/jb/mvr141
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Molecular structure and function of bacterial nitric oxide reductase
Tomoya Hino, Shingo Nagano, Hiroshi Sugimoto, Takehiko Tosha, Yoshitsugu Shiro
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1817(4)
2012-04
DOI:
10.1016/j.bbabio.2011.09.021
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Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus
Yushi Matsumoto, Takehiko Tosha, Andrei V. Pisliakov, Tomoya Hino, Hiroshi Sugimoto, Shingo Nagano, Yuji Sugita, Yoshitsugu Shiro
NATURE STRUCTURAL & MOLECULAR BIOLOGY 19(2)
2012-02
DOI:
10.1038/nsmb.2213
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G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Tomoya Hino, Takatoshi Arakawa, Hiroko Iwanari, Takami Yurugi-Kobayashi, Chiyo Ikeda-Suno, Yoshiko Nakada-Nakura, Osamu Kusano-Arai, Simone Weyand, Tatsuro Shimamura, Norimichi Nomura, Alexander D. Cameron, Takuya Kobayashi, Takao Hamakubo, So Iwata, Takeshi Murata
NATURE 482(7384)
2012-02
DOI:
10.1038/nature10750
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RNA Interference-Mediated Growth Control of the Southern Root-Knot Nematode Meloidogyne incognita
Yohei Matsunaga, Kayo Kawano, Takashi Iwasaki, Tsuyoshi Kawano
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76(2)
2012-02
DOI:
10.1271/bbb.110661
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Challenge toward gene-therapy using iPS cells for duchenne muscular dystrophy
Clinical Neurology 52(11)
2012
DOI:
10.5692/clinicalneurol.52.1139
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サリドマイドにより催奇形性を示すヒト型CYP3Aクラスター保持マウス
香月 康宏, 小林 カオル, 大島 毅, 墳崎 靖子, 千田 直人, 秋田 正治, 鎌滝 哲也, 阿部 智志, 久保 欣也, 千葉 寛, 押村 光雄
日本毒性学会学術年会 39
2012
DOI:
10.14869/toxpt.39.1.0.P-220.0
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1PT164 Functional and Stopped-flow analysis of circularly permutated GroEL mutant CP86(The 50th Annual Meeting of the Biophysical Society of Japan)
Mizuta Toshifumi, Uemura Tatsuya, Hirayama Takuma, Hongo Kunihiro, Kawata Yasushi, Mizobata Tomohiro
Seibutsu Butsuri 52
2012
DOI:
10.2142/biophys.52.S97_1
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Semi-synthesis of an artificial scandium(III) enzyme with a beta-helical bio-nanotube
Hiroshi Inaba, Shuji Kanamaru, Fumio Arisaka, Susumu Kitagawa, Takafumi Ueno
DALTON TRANSACTIONS 41(37)
2012
DOI:
10.1039/c2dt31030a
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The regulation of cell function by linkage-specific polyubiquitin binding
Seikagaku 84(9)
2012
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Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM(1) gangliosidosis
M. Aguilar-Moncayo, T. Takai, K. Higaki, T. Mena-Barragan, Y. Hirano, K. Yura, L. Li, Y. Yu, H. Ninomiya, M. I. Garcia-Moreno, S. Ishii, Y. Sakakibara, K. Ohno, E. Nanba, C. Ortiz Mellet, J. M. Garcia Fernandez, Y. Suzuki
CHEMICAL COMMUNICATIONS 48(52)
2012
DOI:
10.1039/c2cc32065g
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Conformationally-Locked N-Glycosides with Selective β-Glycosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease.
Castella J, Risquez R, Cruz D, Higaki K, Nanba E, Ohno K, Suzuki Y, Diaz Y, Ortiz Mellet C, García Fernández JM, Castellon S
J Med Chem, 55
2012
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Evolution of subtelomeric and centromeric repetitive sequences in genus Pennisetum (Poaceae)
Ishii Takayoshi, Matsumoto Naoya, Tanaka Hiroyuki, Eltayeb Amin Elsadig, Tsujimoto Hisashi
Chromosome Science 15(3+4)
2012
DOI:
10.11352/scr.15.53
