研究成果
2017年
-
Identification of Candidate Progenitor Populations Which Causes Transient Abnormal Myelopoiesis
Nishinaka-Arai Yoko, Niwa Akira, Matsuo Shiori, Kazuki Yasuhiro, Yakura Yuwna, Oshimura Mitsuo, Nakahata Tatsutoshi, Saito Megumu K
BLOOD 130
2017-12-07
-
人工染色体ベクターとSplit-luciferaseを用いた、G protein-coupled receptorの活性化応答性評価システムの構築
宇野 愛海, 藤本 智仁, 古本 真也, 澤 匡明, 香月 康宏, 押村 光雄
生命科学系学会合同年次大会 2017年度
2017-12
-
アミロイド線維形成抑制に働く天然物化合物の探索
進藤 愛未, 小川 健二郎, 本郷 邦宏, 溝端 知宏, 小林 沙織, 河田 康志
生命科学系学会合同年次大会 2017年度
2017-12
-
Extreme Suppression of Lateral Floret Development by a Single Amino Acid Change in the VRS1 Transcription Factor
Shun Sakuma, Udda Lundqvist, Yusuke Kakei, Venkatasubbu Thirulogachandar, Takako Suzuki, Kiyosumi Hori, Jianzhong Wu, Akemi Tagiri, Twan Rutten, Ravi Koppolu, Yukihisa Shimada, Kelly Houston, William T. B. Thomas, Robbie Waugh, Thorsten Schnurbusch, Takao Komatsuda
PLANT PHYSIOLOGY 175(4)
2017-12
DOI:
10.1104/pp.17.01149
-
Reversible immortalisation allows genetic correction of human skeletal muscle progenitors and generation of novel human artificial chromosomes for Duchenne muscular dystrophy
S. Benedetti, U. Narumi, H. Hoshiya, M. Ragazzi, G. Ferrari, Y. Kazuki, L. A. Moyle, R. Tonlorenzi, A. Lombardo, S. Chaouch, V. Mouly, M. Moore, L. Popplewell, K. Kazuki, M. Katoh, L. Naldini, G. Dickson, G. Messina, M. Oshimura, G. Cossu, F. S. Tedesco
HUMAN GENE THERAPY 28(12)
2017-12
-
Functional Characterization of VEGF- and FGF-induced Tumor Blood Vessel Models in Human Cancer Xenografts.
Yusaku Hori, Ken Ito, Shusei Hamamichi, Yoichi Ozawa, Junji Matsui, Izumi O Umeda, Hirofumi Fujii
Anticancer research 37(12)
2017-12
-
Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology
Satoshi Abe, Kaoru Kobayashi, Asami Oji, Tetsushi Sakuma, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Azusa Okada, Yasuko Tsukazaki, Naoto Senda, Kazuhisa Honma, Takashi Yamamoto, Masahito Ikawa, Kan Chiba, Mitsuo Oshimura, Yasuhiro Kazuki
SCIENTIFIC REPORTS 7(1)
2017-11
DOI:
10.1038/s41598-017-15033-0
-
Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.
Yusuke Sato, Kei Okatsu, Yasushi Saeki, Koji Yamano, Noriyuki Matsuda, Ai Kaiho, Atsushi Yamagata, Sakurako Goto-Ito, Minoru Ishikawa, Yuichi Hashimoto, Keiji Tanaka, Shuya Fukai
Nature structural & molecular biology 24(11)
2017-11
DOI:
10.1038/nsmb.3469
-
Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models.
Ken Ito, Shusei Hamamichi, Takanori Abe, Tsuyoshi Akagi, Hiroshi Shirota, Satoshi Kawano, Makoto Asano, Osamu Asano, Akira Yokoi, Junji Matsui, Izumi O Umeda, Hirofumi Fujii
Cancer science 108(11)
2017-11
DOI:
10.1111/cas.13392
-
Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice
Takashi Shinohara, Kanako Kazuki, Narumi Ogonuki, Hiroko Morimoto, Shogo Matoba, Kei Hiramatsu, Kazuhisa Honma, Teruhiko Suzuki, Takahiko Hara, Atsuo Ogura, Mitsuo Oshimura, Mito Kanatsu-Shinohara, Yasuhiro Kazuki
STEM CELL REPORTS 9(4)
2017-10
DOI:
10.1016/j.stemcr.2017.08.012
-
CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells
Narumi Uno, Kei Hiramatsu, Katsuhiro Uno, Shinya Komoto, Yasuhiro Kazuki, Mitsuo Oshimura
SCIENTIFIC REPORTS 7(1)
2017-10
DOI:
10.1038/s41598-017-10418-7
-
Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies
Daisuke Satoh, Satoru Iwado, Satoshi Abe, Kanako Kazuki, Shinobu Wakuri, Mitsuo Oshimura, Yasuhiro Kazuki
PLOS ONE 12(10)
2017-10
DOI:
10.1371/journal.pone.0187072
-
Crystal structures of TdsC, a dibenzothiophene monooxygenase from the thermophile Paenibacillus sp A11-2, reveal potential for expanding its substrate selectivity
Tomoya Hino, Haruka Hamamoto, Hirokazu Suzuki, Hisashi Yagi, Takashi Ohshiro, Shingo Nagano
JOURNAL OF BIOLOGICAL CHEMISTRY 292(38)
2017-09
DOI:
10.1074/jbc.M117.788513
-
Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity
Norie Murayama, Yasuhiro Kazuki, Daisuke Satoh, Kazuya Arata, Tasuku Harada, Norio Shibata, F. Peter Guengerich, Hiroshi Yamazaki
JOURNAL OF TOXICOLOGICAL SCIENCES 42(3)
2017-06
DOI:
10.2131/jts.42.343
-
Identification of MicroRNAs Involved in Resistance to Sunitinib in Renal Cell Carcinoma Cells
Noriya Yamaguchi, Mitsuhiko Osaki, Kunishige Onuma, Tetsuya Yumioka, Hideto Iwamoto, Takehiro Sejima, Hiroyuki Kugoh, Atsushi Takenaka, Futoshi Okada
ANTICANCER RESEARCH 37(6)
2017-06
DOI:
10.21873/anticanres.11652
-
Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase
S. Wakuri, K. Yamakage, Y. Kazuki, K. Kazuki, M. Oshimura, S. Aburatani, M. Yasunaga, Y. Nakajima
Analytical Biochemistry 522
2017-04
DOI:
10.1016/j.ab.2017.01.015
-
Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease
Keiko Nagata, Keisuke Kumata, Yuji Nakayama, Yukio Satoh, Hirotsugu Sugihara, Sayuri Hara, Michiko Matsushita, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Kazuhiko Hayashi
VIRAL IMMUNOLOGY 30(3)
2017-04
DOI:
10.1089/vim.2016.0179
-
Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction
Yusuke Kanda, Mitsuhiko Osaki, Futoshi Okada
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18(4)
2017-04
DOI:
10.3390/ijms18040867
-
Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome
Kosuke Tomimatsu, Kenji Kokura, Tadashi Nishida, Yuki Yoshimura, Yasuhiro Kazuki, Masashi Narita, Mitsuo Oshimura, Tetsuya Ohbayashi
FEBS OPEN BIO 7(3)
2017-03
DOI:
10.1002/2211-5463.12169
-
Gender difference of hepatic and intestinal CYP3A4 in CYP3A-humanized mice generated by a human chromosome-engineering technique
Kaoru Kobayashi, Chihiro Abe, Mika Endo, Yasuhiro Kazuki, Mitsuo Oshimura, Kan Chiba
Drug Metabolism Letters 11(1)
2017-03-01
DOI:
10.2174/1872312811666170404153804
-
Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates
Stephane Diring, Arnau Carne-Sanchez, JiCheng Zhang, Shuya Ikemura, Chiwon Kim, Hiroshi Inaba, Susumu Kitagawa, Shuhei Furukawa
CHEMICAL SCIENCE 8(3)
2017-03
DOI:
10.1039/c6sc04824b
-
Fluorinated Chaperone-beta-Cyclodextrin Formulations for beta-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease
M. Isabel Garcia-Moreno, Mario de la Mata, Elena M. Sanchez-Fernandez, Juan M. Benito, Antonio Diaz-Quintana, Santos Fustero, Eiji Nanba, Katsumi Higaki, Jose A. Sanchez-Alcazar, Jose M. Garcia Fernandez, Carmen Ortiz Mellett
JOURNAL OF MEDICINAL CHEMISTRY 60(5)
2017-03
DOI:
10.1021/acs.jmedchem.6b01550
-
Normalization of Hepatic Homeostasis in the Npc1(nmf164) Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat
Andrew B. Munkacsi, Natalie Hammond, Remy T. Schneider, Dinindu S. Senanayake, Katsumi Higaki, Kirill Lagutin, Stephen J. Bloor, Daniel S. Ory, Robert A. Maue, Fannie W. Chen, Antonio Hernandez-Ono, Nicole Dahlson, Joyce J. Repa, Henry N. Ginsberg, Yiannis A. Ioannou, Stephen L. Sturleyj
JOURNAL OF BIOLOGICAL CHEMISTRY 292(11)
2017-03
DOI:
10.1074/jbc.M116.770578
-
Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases
Yusuke Kanda, Mitsuhiko Osaki, Kunishige Onuma, Ayana Sonoda, Masanobu Kobayashi, Junichi Hamada, Garth L. Nicolson, Takahiro Ochiya, Futoshi Okada
SCIENTIFIC REPORTS 7
2017-03
DOI:
10.1038/srep43567
-
Centromere location in Arabidopsis is unaltered by extreme divergence in CENH3 protein sequence
Shamoni Maheshwari, Takayoshi Ishii, C. Titus Brown, Andreas Houben, Luca Comai
GENOME RESEARCH 27(3)
2017-03
DOI:
10.1101/gr.214619.116
-
Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.
Sakurako Goto-Ito, Atsushi Yamagata, Tomio S Takahashi, Yusuke Sato, Shuya Fukai
Scientific reports 7
2017-02-08
DOI:
10.1038/srep42123
-
Maintenance and Function of a Plant Chromosome in Human Cells
Naoki Wada, Yasuhiro Kazuki, Kanako Kazuki, Toshiaki Inoue, Kiichi Fukui, Mitsuo Oshimura
ACS SYNTHETIC BIOLOGY 6(2)
2017-02
DOI:
10.1021/acssynbio.6b00180
-
Development of Caco-2 cells co-expressing CYP3A4 and NADPHcytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates
Toru Takenaka, Kanako Kazuki, Naomoto Harada, Jiro Kuze, Masato Chiba, Takahiro Iwao, Tamihide Matsunaga, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki
DRUG METABOLISM AND PHARMACOKINETICS 32(1)
2017-02
DOI:
10.1016/j.dmpk.2016.08.004
-
Crystal structure of Sec10, a subunit of the exocyst complex.
Jianxing Chen, Atsushi Yamagata, Keiko Kubota, Yusuke Sato, Sakurako Goto-Ito, Shuya Fukai
Scientific reports 7
2017-01-18
DOI:
10.1038/srep40909
-
Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts
Nobuhito Ikeda, Natsumi Nakazawa, Yasutaka Kurata, Hisako Yaura, Fikri Taufiq, Hiroyuki Minato, Akio Yoshida, Haruaki Ninomiya, Yuji Nakayama, Masanari Kuwabara, Yasuaki Shirayoshi, Ichiro Hisatome
BIOMEDICAL RESEARCH-TOKYO 38(4)
2017
-
Common structural features of toxic intermediates from alpha-synuclein and GroES fibrillogenesis detected using cryogenic coherent X-ray diffraction imaging
Hiroshi Kameda, Sayaka Usugi, Mana Kobayashi, Naoya Fukui, Seki Lee, Kunihiro Hongo, Tomohiro Mizobata, Yuki Sekiguchi, Yu Masaki, Amane Kobayashi, Tomotaka Oroguchi, Masayoshi Nakasako, Yuki Takayama, Masaki Yamamoto, Yasushi Kawata
JOURNAL OF BIOCHEMISTRY 161(1)
2017-01
DOI:
10.1093/jb/mvw052
-
VRS2 regulates hormone-mediated inflorescence patterning in barley
Helmy M. Youssef, Kai Eggert, Ravi Kopplu, Ahmad M. Alqudah, Naser Poursarebani, Arash Fazeli, Shun Sakuma, Akemi Tagiri, Twan Rutten, Geetha Govind, Udda Lundqvist, Andreas Graner, Takao Komatsuda, Nese Sreenivasulu, Thorsten Schnurbusch
NATURE GENETICS 49(1)
2017-01
DOI:
10.1038/ng.3717
-
Role of 6-O-α-maltosyl-β-cyclodextrin in lysosomal cholesterol deprivation in Npc1-deficient Chinese hamster ovary cells.
Okada Y, Ueda E, Kondo Y, Ishitsuka Y, Irie T, Higashi T, Motoyama K, Arima H, Matuso M, Higaki K, Ohno K, Nishikawa J, Ichikawa A
Carbohydr Res. 10
2017
-
(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B.
Front S, Biela-Banaś A, Burda P, Ballhausen D, Higaki K, Caciotti A, Morrone A, Charollais-Thoenig J, Gallienne E, Demotz S, Martin OR
Eur J Med Chem 126
2017
-
Research on post-fertilization barriers in the context of plant breeding
Ishii T, Okamoto T, Tonosaki K, Nagaki K, Kinoshita T
Breed. Res. 19(1)
2017
DOI:
10.1270/jsbbr.19.35
-
Wide hybridization between oat and pearl millet
Ishii, T.
Methods in Molecular Biology 1536
2017
DOI:
10.1007/978-1-4939-6682-0_3
-
Short polyhistidine peptides penetrate effectively into Nicotiana tabacum-cultured cells and Saccharomyces cerevisiae cells
Sayaka Kimura, Tsuyoshi Kawano, Takashi Iwasaki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 81(1)
2017-01
DOI:
10.1080/09168451.2016.1234925
-
Diverse insulin-like peptides in Caenorhabditis elegans
Yohei Matsunaga, Takashi Iwasaki, Tsuyoshi Kawano
International Biology Review 1(1)
2017
DOI:
10.18103/ibr.v1i1.1276
