研究成果
2023年
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Photoresponsive peptide materials: Spatiotemporal control of self-assembly and biological functions
Kazunori Matsuura, Hiroshi Inaba
Biophysics Reviews 4
2023-12-01
DOI:
10.1063/5.0179171
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A supramolecular system mimicking the infection process of an enveloped virus through membrane fusion
Hiroto Furukawa, Yuuna Kimura, Hiroshi Inaba, Kazunori Matsuura
Scientific Reports 13
2023-11-15
DOI:
10.1038/s41598-023-47347-7
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Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome
Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao
iScience 26(12)
2023-11
DOI:
10.1016/j.isci.2023.108379
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Construction of Silver Nanoparticles inside Microtubules Using Tau-Derived Peptide Ligated with Silver-Binding Peptide
Hiroshi Inaba, Yuma Hori, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
Bulletin of the Chemical Society of Japan 96(10)
2023-10-15
DOI:
10.1246/bcsj.20230162
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A strategy for orthogonal deubiquitination using a bump-and-hole approach
Takumi Suzuki, Yuki Utsugi, Satoshi Yamanaka, Hirotaka Takahashi, Yusuke Sato, Tatsuya Sawasaki, Yusaku Miyamae
RSC Chemical Biology 4(11)
2023-10-02
DOI:
10.1039/d3cb00095h
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【ヒト化動物の最新研究】ヒト化動物を用いた薬物代謝・動態研究への応用
小林 カオル, 香月 康宏
実験動物ニュース 72(4)
2023-10
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Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography.
Alexander M Wolff, Eriko Nango, Iris D Young, Aaron S Brewster, Minoru Kubo, Takashi Nomura, Michihiro Sugahara, Shigeki Owada, Benjamin A Barad, Kazutaka Ito, Asmit Bhowmick, Sergio Carbajo, Tomoya Hino, James M Holton, Dohyun Im, Lee J O'Riordan, Tomoyuki Tanaka, Rie Tanaka, Raymond G Sierra, Fumiaki Yumoto, Kensuke Tono, So Iwata, Nicholas K Sauter, James S Fraser, Michael C Thompson
Nature chemistry
2023-09-18
DOI:
10.1038/s41557-023-01329-4
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Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene.
Masahito Watanabe, Hitomaru Miyamoto, Kazutoshi Okamoto, Kazuaki Nakano, Hitomi Matsunari, Kanako Kazuki, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Kazuhiro Umeyama, Yosuke Hiramuki, Elisabeth Kemter, Nikolai Klymuik, Mayuko Kurome, Barbara Kessler, Eckhard Wolf, Yasuhiro Kazuki, Hiroshi Nagashima
Molecular therapy. Nucleic acids 33
2023-09-12
DOI:
10.1016/j.omtn.2023.07.021
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Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency.
Narumi Uno, Hiroyuki Satofuka, Hitomaru Miyamoto, Kazuhisa Honma, Teruhiko Suzuki, Kyotaro Yamazaki, Ryota Ito, Takashi Moriwaki, Shusei Hamamichi, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Molecular therapy. Nucleic acids 33
2023-09-12
DOI:
10.1016/j.omtn.2023.07.002
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Genome and transcriptome analyses reveal genes involved in the formation of fine ridges on petal epidermal cells in Hibiscus trionum
Shizuka Koshimizu, Sachiko Masuda, Arisa Shibata, Takayoshi Ishii, Ken Shirasu, Atsushi Hoshino, Masanori Arita
DNA Research 30(5)
2023-09-11
DOI:
10.1093/dnares/dsad019
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Metabolic and transcriptomic profiling during wheat seed development under progressive drought conditions.
Ryosuke Mega, June-Sik Kim, Hiroyuki Tanaka, Takayoshi Ishii, Fumitaka Abe, Masanori Okamoto
Scientific reports 13(1)
2023-09-11
DOI:
10.1038/s41598-023-42093-2
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Chemical emasculation in cowpea (Vigna unguiculata (L.) Walp.) and dicotyledonous model species using trifluoromethanesulfonamide (TFMSA)
Yuka Sekiguchi, Benjamin Ewa Ubi, Takayoshi Ishii
Plant Reproduction
2023-09
DOI:
10.1007/s00497-023-00469-4
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Construction of functional microtubules and artificial motile systems based on peptide design
Hiroshi Inaba
Polymer Journal 55(12)
2023-08-31
DOI:
10.1038/s41428-023-00838-w
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Increased chemokine ligand 26 expression and its involvement in epithelial-mesenchymal transition in the endometrium with adenomyosis.
Ai Ikebuchi, Mitsuhiko Osaki, Ikumi Wada, Hiroki Nagata, Kei Nagira, Yukihiro Azuma, Futoshi Okada, Tasuku Harada, Fuminori Taniguchi
Journal of gynecology obstetrics and human reproduction 52(9)
2023-08-18
DOI:
10.1016/j.jogoh.2023.102645
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Correction to: Human artificial chromosome carrying 3p21.3‑p22.2 region suppresses hTERT transcription in oral cancer cells.
Takahito Ohira, Kaho Yoshimura, Hiroyuki Kugoh
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 31(3)
2023-08-17
DOI:
10.1007/s10577-023-09734-8
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ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver.
Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mai Nagaoka, Seiya Takemoto, Yoshiyuki Sakai, Kaoru Kobayashi, Yasuhiro Kazuki, Tatsuki Fukami, Miki Nakajima
Biochemical pharmacology
2023-08-03
DOI:
10.1016/j.bcp.2023.115733
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New liposome-radionuclide-chelate combination for tumor targeting and rapid healthy tissue clearance.
Izumi O Umeda, Yusuke Koike, Mayumi Ogata, Emi Kaneko, Shusei Hamamichi, Tomoya Uehara, Kunikazu Moribe, Yasushi Arano, Tadayuki Takahashi, Hirofumi Fujii
Journal of controlled release : official journal of the Controlled Release Society 361
2023-08-03
DOI:
10.1016/j.jconrel.2023.07.060
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Different solubilizing ability of cyclodextrin derivatives for cholesterol in Niemann–Pick disease type C treatment
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Clinical and Translational Medicine 13(8)
2023-08
DOI:
10.1002/ctm2.1350
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Diversity in the genome of Aegilops tauschii, a wild wheat relative, to generate Fe-biofortified and Fe-deficiency-tolerant wheat
Tomoko Nozoye, Yasir S. A. Gorafi, Naoki Ube, Fan Wang, Hiromi Nakanishi, Atsushi Ishihara, Takayoshi Ishii, Hisashi Tsujimoto
Plant Genetic Resources: Characterization and Utilization 21(1)
2023-07-18
DOI:
10.1017/s1479262123000424
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Co-treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency
Narumi Uno, Hiroyuki Satofuka, Hitomaru Miyamoto, Kazuhisa Honma, Teruhiko Suzuki, Kyotaro Yamazaki, Ryota Ito, Takashi Moriwaki, Shusei Hamamichi, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Molecular Therapy - Nucleic Acids
2023-07
DOI:
10.1016/j.omtn.2023.07.002
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Epstein-Barr virus reactivation in peripheral B lymphocytes induces IgM-type thyrotropin receptor autoantibody production in patients with Graves' disease.
Keiko Nagata, Kazuhiko Hayashi, Keisuke Kumata, Yukio Satoh, Mitsuhiko Osaki, Yuji Nakayama, Satoshi Kuwamoto, Yoshinori Ichihara, Tsuyoshi Okura, Kazuhiko Matsuzawa, Junichiro Miake, Shuji Fukata, Takeshi Imamura
Endocrine journal 70(6)
2023-06-28
DOI:
10.1507/endocrj.EJ22-0609
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Human artificial chromosome carrying 3p21.3-p22.2 region suppresses hTERT transcription in oral cancer cells.
Takahito Ohira, Kaho Yoshimura, Hiroyuki Kugoh
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 31(3)
2023-06-24
DOI:
10.1007/s10577-023-09726-8
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Antigen/Adjuvant-Displaying Enveloped Viral Replica as a Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidate
Keita Ito, Hiroto Furukawa, Hiroshi Inaba, Shino Ohshima, Yoshie Kametani, Masatoshi Maeki, Manabu Tokeshi, Xuhao Huang, Kazuya Kabayama, Yoshiyuki Manabe, Koichi Fukase, Kazunori Matsuura
Journal of the American Chemical Society 145(29)
2023-06-21
DOI:
10.1021/jacs.3c02679
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Holocentromeres can consist of merely a few megabase-sized satellite arrays
Yi-Tzu Kuo, Amanda Souza Câmara, Veit Schubert, Pavel Neumann, Jiří Macas, Michael Melzer, Jianyong Chen, Jörg Fuchs, Simone Abel, Evelyn Klocke, Bruno Huettel, Axel Himmelbach, Dmitri Demidov, Frank Dunemann, Martin Mascher, Takayoshi Ishii, André Marques, Andreas Houben
Nature Communications 14(1)
2023-06-13
DOI:
10.1038/s41467-023-38922-7
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Binding of Tau-derived peptide-fused GFP to plant microtubules in Arabidopsis thaliana
Hiroshi Inaba, Kazusato Oikawa, Kazuya Ishikawa, Yutaka Kodama, Kazunori Matsuura, Keiji Numata
PLoS ONE 18(6)
2023-06-02
DOI:
10.1371/journal.pone.0286421
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An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells
Kentarou Sakamoto, Kohsuke Uchiyama, Takashi Iwasaki, Hiroshi Inaba, Kazunori Matsuura
Journal of Materials Chemistry B 11(26)
2023-06
DOI:
10.1039/d3tb00169e
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The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming growth factor-β DAF-7 protein in Caenorhabditis elegans
Masahiro Ono, Kenjiro Matsushita, Sho Maega, Naoto Asano, Yohei Matsunaga, Tomohiro Bito, Takashi Iwasaki, Tsuyoshi Kawano
Biochemical and Biophysical Research Communications 660
2023-06
DOI:
10.1016/j.bbrc.2023.03.080
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AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk
Yuki Iida, Mitsuhiko Osaki, Shinya Sato, Runa Izutsu, Heekyung Seong, Masayo Okawa, Daiken Osaku, Hiroaki Komatsu, Fuminori Taniguchi, Futoshi Okada
Molecular and Clinical Oncology 19(1)
2023-05-26
DOI:
10.3892/mco.2023.2652
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Development of Dynamic Bionanostructures Based on Peptides: Molecular Encapsulation Inside Microtubules and Light-induced Propulsion of Microspheres
Hiroshi Inaba
Chemistry Letters 52(6)
2023-05-11
DOI:
10.1246/cl.230121
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Dramatic morphological changes in liposomes induced by peptide nanofibers reversibly polymerized and depolymerized by the photoisomerization of spiropyran
Yingbing Liang, Shigesaburo Ogawa, Hiroshi Inaba, Kazunori Matsuura
Frontiers in Molecular Biosciences 10
2023-03-30
DOI:
10.3389/fmolb.2023.1137885
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Reversible Photocontrol of Microtubule Stability by Spiropyran‐Conjugated Tau‐Derived Peptides
Hiroshi Inaba, Minamo Sakaguchi, Soei Watari, Shigesaburo Ogawa, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
ChemBioChem
2023-03-29
DOI:
10.1002/cbic.202200782
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Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model
Yosuke Hiramuki, Satoshi Abe, Narumi Uno, Kanako Kazuki, Shuta Takata, Hitomaru Miyamoto, Haruka Takayama, Kayoko Morimoto, Shoko Takehara, Mitsuhiko Osaki, Jun Tanihata, Shin’ichi Takeda, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Scientific Reports 13(1)
2023-03-16
DOI:
10.1038/s41598-023-31481-3
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Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate
Hiroyuki Satofuka, Yayan Wang, Kyotaro Yamazaki, Shusei Hamamichi, Takeshi Fukuhara, Abdur Rafique, Nana Osako, Iori Kanazawa, Takeshi Endo, Naomi Miyake, Kazuhisa Honma, Yuichi Nagashima, Genki Hichiwa, Kazuto Shimoya, Satoshi Abe, Takashi Moriwaki, Yasufumi Murakami, Xu Gao, Hiroyuki Kugoh, Mitsuo Oshimura, Yuji Ito, Yasuhiro Kazuki
Scientific Reports 13(1)
2023-03-14
DOI:
10.1038/s41598-023-31263-x
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Form follows function in Triticeae inflorescences.
Shun Sakuma, Ravi Koppolu
Breeding science 73(1)
2023-03
DOI:
10.1270/jsbbs.22085
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Publisher Correction: Simultaneous loading of PCR-based multiple fragments on mouse artificial chromosome vectors in DT40 cell for gene delivery.
Kyotaro Yamazaki, Kyosuke Matsuo, Akane Okada, Narumi Uno, Teruhiko Suzuki, Satoshi Abe, Shusei Hamamichi, Nanami Kishima, Shota Togai, Kazuma Tomizuka, Yasuhiro Kazuki
Scientific reports 13(1)
2023-02-28
DOI:
10.1038/s41598-023-30359-8
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De novo induction of a DNA-histone H3K9 methylation loop on synthetic human repetitive DNA in cultured tobacco cells.
Koichiro Otake, Kazuto Kugou, Jekson Robertlee, Jun-Ichirou Ohzeki, Koei Okazaki, Shigeru Hanano, Seiji Takahashi, Daisuke Shibata, Hiroshi Masumoto
The Plant journal : for cell and molecular biology 114(3)
2023-02-24
DOI:
10.1111/tpj.16164
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Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis.
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobumasa Takasugi, Kunishige Onuma, Mitsuhiko Osaki, Futoshi Okada, Taichi Ukegawa, Yasuo Takeuchi, Norihisa Yasui, Atsuko Yamashita, Hiroyuki Marusawa, Yosuke Matsushita, Toyomasa Katagiri, Takahiro Shibata, Koji Uchida, Sheng-Yong Niu, Nhi B Lang, Tomohiro Nakamura, Kam Y J Zhang, Stuart A Lipton, Takashi Uehara
Nature communications 14(1)
2023-02-04
DOI:
10.1038/s41467-023-36232-6
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Pathological Comparison of TDP-43 Between Motor Neurons and Interneurons Expressed by a Tetracycline Repressor System on the Mouse Artificial Chromosome.
Shota Togai, Shusei Hamamichi, Yasuhiro Kazuki, Masaharu Hiratsuka
Yonago acta medica 66(1)
2023-02
DOI:
10.33160/yam.2023.02.004
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TYRO3 promotes chemoresistance via increased LC3 expression in pancreatic cancer.
Kazushi Hara, Yosuke Horikoshi, Masaki Morimoto, Kazuhiro Nakaso, Teppei Sunaguchi, Tatsuyuki Kurashiki, Yuji Nakayama, Takehiko Hanaki, Manabu Yamamoto, Teruhisa Sakamoto, Yoshiyuki Fujiwara, Tatsuya Matsura
Translational oncology 28
2023-02
DOI:
10.1016/j.tranon.2022.101608
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Effects of the Polyphenols Delphinidin and Rosmarinic Acid on the Inducible Intra-cellular Aggregation of Alpha-Synuclein in Model Neuron Cells
Hanae Yamamoto, Rio Matsumura, Miho Nakashima, Mayuka Adachi, Kenjirou Ogawa, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
Applied Biochemistry and Biotechnology
2023-01-19
DOI:
10.1007/s12010-023-04362-8
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Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis.
Yusuke Sato, Seigo Terawaki, Daisuke Oikawa, Kouhei Shimizu, Yoshinori Okina, Hidefumi Ito, Fuminori Tokunaga
Frontiers in molecular biosciences 10
2023-01-16
DOI:
10.3389/fmolb.2023.1089213
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Anammox Bacterial S-Adenosyl-l-Methionine Dependent Methyltransferase Crystal Structure and Its Interaction with Acyl Carrier Proteins.
Tesshin Uegaki, Taisei Takei, Shuhei Yamaguchi, Keisuke Fujiyama, Yusuke Sato, Tomoya Hino, Shingo Nagano
International journal of molecular sciences 24(1)
2023-01-01
DOI:
10.3390/ijms24010744
