研究成果
2018年
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Light-induced propulsion of a giant liposome driven by peptide nanofibre growth
Hiroshi Inaba, Akihito Uemura, Kazushi Morishita, Taiki Kohiki, Akira Shigenaga, Akira Otaka, Kazunori Matsuura
Scientific Reports 8(1)
2018-12-01
DOI:
10.1038/s41598-018-24675-7
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Crystal structure of the central and the C-terminal RNase domains of colicin D implicated its translocation pathway through inner membrane of target cell.
Jung-Wei Chang, Yusuke Sato, Tetsuhiro Ogawa, Takatoshi Arakawa, Shuya Fukai, Shinya Fushinobu, Haruhiko Masaki
Journal of biochemistry 164(5)
2018-11-01
DOI:
10.1093/jb/mvy056
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New insights into the efficacy of SR-16234, a selective estrogen receptor modulator, on the growth of murine endometriosis-like lesions.
Khine YM, Taniguchi F, Nagira K, Nakamura K, Ohbayashi T, Osaki M, Harada T
American journal of reproductive immunology (New York, N.Y. : 1989) 80(5)
2018-11
DOI:
10.1111/aji.13023
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Molecular Encapsulation Inside Microtubules Based on Tau-Derived Peptides
Hiroshi Inaba, Takahisa Yamamoto, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
Chemistry - A European Journal 24(56)
2018-10-09
DOI:
10.1002/chem.201802617
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Epstein-Barr Virus Lytic Reactivation Induces IgG4 Production by Host B Lymphocytes in Graves' Disease Patients and Controls: A Subset of Graves' Disease Is an IgG4-Related Disease-Like Condition
Keiko Nagata, Sayuri Hara, Yuji Nakayama, Katsumi Higaki, Hirotsugu Sugihara, Satoshi Kuwamoto, Michiko Matsushita, Masako Kato, Shunsuke Tanio, Kiyosuke Ishiguro, Kazuhiko Hayashi
VIRAL IMMUNOLOGY 31(8)
2018-10
DOI:
10.1089/vim.2018.0042
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Peptide Nanomaterials Designed from Natural Supramolecular Systems
Hiroshi Inaba, Kazunori Matsuura
The Chemical Record 19(5)
2018-10
DOI:
10.1002/tcr.201800149
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Fascin protein stabilization by miR-146a implicated in the process of a chronic inflammation-related colon carcinogenesis model.
Yusuke Kanda, Tokuichi Kawaguchi, Mitsuhiko Osaki, Kunishige Onuma, Takahiro Ochiya, Tomoyuki Kitagawa, Futoshi Okada
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 67(10)
2018-10
DOI:
10.1007/s00011-018-1175-2
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Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida, Takeshi Uemura, Shuya Fukai
Nature communications 9(1)
2018-09-27
DOI:
10.1038/s41467-018-06333-8
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Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.
Kouprina N, Petrov N, Molina O, Liskovykh M, Pesenti E, Ohzeki JI, Masumoto H, Earnshaw WC, Larionov V
ACS synthetic biology
2018-08
DOI:
10.1021/acssynbio.8b00230
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Structural insights into ubiquitin phosphorylation by PINK1.
Kei Okatsu, Yusuke Sato, Koji Yamano, Noriyuki Matsuda, Lumi Negishi, Akiko Takahashi, Atsushi Yamagata, Sakurako Goto-Ito, Masaki Mishima, Yutaka Ito, Toshihiko Oka, Keiji Tanaka, Shuya Fukai
Scientific reports 8(1)
2018-07-10
DOI:
10.1038/s41598-018-28656-8
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A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors.
Uno N, Fujimoto T, Komoto S, Kurosawa G, Sawa M, Suzuki T, Kazuki Y, Oshimura M
Cytotechnology 70(6)
2018-07
DOI:
10.1007/s10616-018-0231-7
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Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1
Chelsea Anorma, Jamila Hedhli, Thomas E. Bearrood, Nicholas W. Pino, Sarah H. Gardner, Hiroshi Inaba, Pamela Zhang, Yanfen Li, Daven Feng, Sara E. Dibrell, Kristopher A. Kilian, Lawrence W. Dobrucki, Timothy M. Fan, Jefferson Chan
ACS Central Science 4(8)
2018-07
DOI:
10.1021/acscentsci.8b00313
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Drug delivery using polyhistidine peptide-modified liposomes that target endogenous lysosome
Taiki Hayashi, Matsumi Shinagawa, Tsuyoshi Kawano, Takashi Iwasaki
Biochemical and Biophysical Research Communications 501(3)
2018-06-27
DOI:
10.1016/j.bbrc.2018.05.037
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Protoporphyrinogen oxidase is involved in the fluorescence intensity of 5-aminolevulinic acid-mediated laser-based photodynamic endoscopic diagnosis for early gastric cancer.
Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto
Photodiagnosis and photodynamic therapy 22
2018-06
DOI:
10.1016/j.pdpdt.2018.02.005
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Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells.
Katsuhiro Uno, Kazutoshi Murotomi, Yasuhiro Kazuki, Mitsuo Oshimura, Yoshihiro Nakajima
Luminescence : the journal of biological and chemical luminescence 33(3)
2018-05
DOI:
10.1002/bio.3454
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Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.
Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y
Drug metabolism and disposition: the biological fate of chemicals 46(11)
2018-05
DOI:
10.1124/dmd.118.081216
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Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice
Shin-ichiro Nitta, Mari Hashimoto, Yasuhiro Kazuki, Shoko Takehara, Hiraku Suzuki, Mitsuo Oshimura, Hidetaka Akita, Kan Chiba, Kaoru Kobayashi
AAPS Journal 20(3)
2018-05-01
DOI:
10.1208/s12248-018-0186-9
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人工染色体を利用した化学物質の染色体不安定化誘発能の新規評価系の開発
柏木 明子, 中山 祐二, 久郷 裕之
産業衛生学雑誌 60(臨増)
2018-05
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Resequencing theVrs1 gene in Spanish barley landraces revealed reversion of six-rowed to two-rowed spike
Ana M. Casas, Bruno Contreras-Moreira, Carlos P. Cantalapiedra, Shun Sakuma, María Pilar Gracia, Marian Moralejo, José Luis Molina-Cano, Takao Komatsuda, Ernesto Igartua
Molecular Breeding 38(5)
2018-05-01
DOI:
10.1007/s11032-018-0816-z
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Elucidation of the origin of ‘agriocrithon’ based on domestication genes questions the hypothesis that Tibet is one of the centers of barley domestication
Mohammad Pourkheirandish, Hiroyuki Kanamori, Jianzhong Wu, Shun Sakuma, Frank R. Blattner, Takao Komatsuda
Plant Journal 94(3)
2018-05-01
DOI:
10.1111/tpj.13876
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An efficient screening method for purifying and crystallizing membrane proteins using modified clear-native PAGE.
Nanao Suzuki, Yuuki Takamuku, Tomohiro Asakawa, Makoto Inai, Tomoya Hino, So Iwata, Toshiyuki Kan, Takeshi Murata
Analytical biochemistry 548
2018-05-01
DOI:
10.1016/j.ab.2018.02.007
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Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Atsushi Yamagata, Yuri Miyazaki, Norihiko Yokoi, Hideki Shigematsu, Yusuke Sato, Sakurako Goto-Ito, Asami Maeda, Teppei Goto, Makoto Sanbo, Masumi Hirabayashi, Mikako Shirouzu, Yuko Fukata, Masaki Fukata, Shuya Fukai
Nature communications 9(1)
2018-04-18
DOI:
10.1038/s41467-018-03947-w
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The versatile mutational “repertoire” of Escherichia coli GroEL, a multidomain chaperonin nanomachine
Tomohiro Mizobata, Yasushi Kawata
Biophysical Reviews 10(2)
2018-04-01
DOI:
10.1007/s12551-017-0332-0
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Artificial bio-nanomachines based on protein needles derived from bacteriophage T4
Hiroshi Inaba, Takafumi Ueno
Biophysical Reviews 10(2)
2018-04-01
DOI:
10.1007/s12551-017-0336-9
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SK-216, a Novel Inhibitor of Plasminogen Activator Inhibitor-1, Suppresses Lung Metastasis of Human Osteosarcoma.
Minori Tsuge, Mitsuhiko Osaki, Ryo Sasaki, Mio Hirahata, Futoshi Okada
International journal of molecular sciences 19(3)
2018-03-05
DOI:
10.3390/ijms19030736
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Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9
Kazuhisa Honma, Satoshi Abe, Takeshi Endo, Narumi Uno, Mitsuo Oshimura, Tetsuya Ohbayashi, Yasuhiro Kazuki
PLoS ONE 13(3)
2018-03-01
DOI:
10.1371/journal.pone.0193642
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Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models
Narumi Uno, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki
Journal of Human Genetics 63(2)
2018-02-01
DOI:
10.1038/s10038-017-0378-7
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Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy
Sara Benedetti, Narumi Uno, Hidetoshi Hoshiya, Martina Ragazzi, Giulia Ferrari, Yasuhiro Kazuki, Louise Anne Moyle, Rossana Tonlorenzi, Angelo Lombardo, Soraya Chaouch, Vincent Mouly, Marc Moore, Linda Popplewell, Kanako Kazuki, Motonobu Katoh, Luigi Naldini, George Dickson, Graziella Messina, Mitsuo Oshimura, Giulio Cossu, Francesco Saverio Tedesco
EMBO Molecular Medicine 10(2)
2018-02-01
DOI:
10.15252/emmm.201607284
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Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics
Daisuke Satoh, Satoshi Abe, Kaoru Kobayashi, Yoshihiro Nakajima, Mitsuo Oshimura, Yasuhiro Kazuki
Drug Metabolism and Pharmacokinetics 33(1)
2018-02-01
DOI:
10.1016/j.dmpk.2018.01.002
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Genetic variation and association mapping of grain iron and zinc contents in synthetic hexaploid wheat germplasm
Yasir S. A. Gorafi, Takayoshi Ishii, June-Sik Kim, Awad Ahmed Elawad Elbashir, Hisashi Tsujimoto
Plant Genetic Resources: Characterization and Utilization 16(1)
2018-02
DOI:
10.1017/s1479262116000265
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Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation.
Sakurako Goto-Ito, Atsushi Yamagata, Yusuke Sato, Takeshi Uemura, Tomoko Shiroshima, Asami Maeda, Ayako Imai, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai
Nature communications 9(1)
2018-01-18
DOI:
10.1038/s41467-017-02417-z
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Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168.
Tomio S Takahashi, Yoshihiro Hirade, Aya Toma, Yusuke Sato, Atsushi Yamagata, Sakurako Goto-Ito, Akiko Tomita, Shinichiro Nakada, Shuya Fukai
Nature communications 9(1)
2018-01-12
DOI:
10.1038/s41467-017-02345-y
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On the origin of the non-brittle rachis trait of domesticated einkorn wheat
Mohammad Pourkheirandish, Fei Dai, Shun Sakuma, Hiroyuki Kanamori, Assaf Distelfeld, George Willcox, Taihachi Kawahara, Takashi Matsumoto, Benjamin Kilian, Takao Komatsuda
Frontiers in Plant Science 8
2018-01-04
DOI:
10.3389/fpls.2017.02031
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Production of a human cell line with a plant chromosome
Naoki Wada, Yasuhiro Kazuki, Kanako Kazuki, Toshiaki Inoue, Kiichi Fukui, Mitsuo Oshimura
Methods in Molecular Biology 1772
2018
DOI:
10.1007/978-1-4939-7795-6_16
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Probing the inhibitor versus chaperone properties of sp2-iminosugars towards human b-glucocerebrosidase: a picomolar chaperone for Gaucher disease.
Mena-Barragán T, García-Moreno MI, Sevsek A, Okazaki T, Nanba E, Higaki K, Martin MI, Pieters RJ, García Fernández JM, Ortiz Mellet C
Molecules
2018
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Lysosome-associated membrane protein 2 (LAMP-2) expression induced by miR-194-5p downregulation contributes to sunitinib resistance in human renal cell carcinoma cells.
Tetsuya Yumioka, Mitsuhiko Osaki, Ryo Sasaki, Noriya Yamaguchi, Kunishige Onuma, Hideto Iwamoto, Shuichi Morizane, Masashi Honda, Atsushi Takenaka, Futoshi Okada
Oncology letters 15(1)
2018-01
DOI:
10.3892/ol.2017.7423
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Comparison of physiological functions of antagonistic insulin-like peptides, INS-23 and INS-18, in Caenorhabditis elegans
Yohei Matsunaga, Toshiya Matsukawa, Takashi Iwasaki, Koji Nagata, Tsuyoshi Kawano
Bioscience, Biotechnology and Biochemistry 82(1)
2018
DOI:
10.1080/09168451.2017.1415749