研究成果
2025年
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Speed breeding for pearl millet and wild Pennisetum species with optimized pot size, CO₂ supplementation, and ABA application
Kosei Terada, Nasrein Mohamed Kamal, Shun Sakuma, Takayoshi Ishii
Discover Applied Sciences 8(1)
2025-12-02
DOI:
10.1007/s42452-025-08041-7
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Perfluoroalkyl Chain-Modified Artificial Viral Capsid for Enhanced Intracellular Delivery of mRNA
Avijit Ghosh, Yuka Yamamoto, Mizuki Wada, Hiroshi Inaba, Kohsuke Aikawa, Yu Ota, Takashi Okazoe, Kazunori Matsuura
Bioconjugate Chemistry
2025-11-28
DOI:
10.1021/acs.bioconjchem.5c00477
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Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor-stroma interactions and carcinogenesis.
Masayo Okawa, Hiroaki Komatsu, Yasuhiro Kazuki, Kanako Kazuki, Genki Hichiwa, Kohei Hikino, Yuki Iida, Mayumi Sawada, Hiroyuki Kugoh, Shinya Sato, Mitsuo Oshimura, Tasuku Harada, Fuminori Taniguchi
Human cell 39(1)
2025-11-26
DOI:
10.1007/s13577-025-01324-6
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Inter-subfamily cybrid plants between wheat and maize, Zeawheat: production via an in vitro fertilization system, genome composition, and photosynthetic type
Nonoka Onda, Aya Satoh, Farzana Nowroz, Tety Maryenti, Offiong Ukpong Edet, Ryosuke Mega, Takayoshi Ishii, Takashi Okamoto
Journal of Experimental Botany
2025-11-17
DOI:
10.1093/jxb/eraf354
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Matrix Metalloproteinase-1 as an Independent Prognostic Biomarker in Epithelial Ovarian Carcinoma.
Kohei Hikino, Hiroaki Komatsu, Yasuhiro Kazuki, Kanako Kazuki, Koji Yamamoto, Masayo Okawa, Yuki Iida, Mayumi Sawada, Genki Hichiwa, Shinya Sato, Hiroyuki Kugoh, Mitsuo Oshimura, Tasuku Harada, Fuminori Taniguchi
Anticancer research 45(10)
2025-10
DOI:
10.21873/anticanres.17795
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CXCL14 is an essential modulator of TLR9 agonist-induced antitumor immune responses.
Kosuke Tanegashima, Eiji Esashi, Koji Ishida, Ayumi Kotaki, Rina Iwase, Manaka Hasebe, Rena Takahashi, Risa Saito, Yasuhiro Kazuki, Teruhiko Suzuki, Takahiko Hara
Journal of immunology (Baltimore, Md. : 1950) 214(8)
2025-08-01
DOI:
10.1093/jimmun/vkaf080
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Targeting of bowel tissue by fully human antibodies cross-reactive with human and mouse GPA33 antigen.
Genki Hichiwa, Abdur Rafique, Asaki Nagashima, Yayan Wang, Kanako Kazuki, Ryohei Ogihara, Muhammad Feisal Jatnika, Ryosuke Shimamoto, Yumi Iwai, Narumi Uno, Hiroyuki Satofuka, Kazuma Tomizuka, Yuji Ito, Yasuhiro Kazuki
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 189
2025-08
DOI:
10.1016/j.biopha.2025.118336
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Microglial xCT Is a Novel Therapeutic Target for Traumatic Brain Injury in Model Mice.
Kenichi Matsuda, Yugo Kato, Yusuke Okawara, Makoto Sakamoto, Yosuke Horikoshi, Kazuomi Nakamura, Yuji Nakayama, Hideyo Sato, Masato Homma, Takahiro Ueda, Kazuhiro Nakaso
Yonago acta medica 68(3)
2025-08
DOI:
10.33160/yam.2025.08.011
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Genetic diversity and structure of Asian cowpea germplasm
Ngozi Paulinus Ofem, Nasrein Mohamed Kamal, Sofie Pearson, Tracey Shatte, David Jordan, Emma Mace, Takayoshi Ishii
Scientific Reports
2025-07-31
DOI:
10.1038/s41598-025-13511-4
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Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration.
Nanami Kishima, Takashi Moriwaki, Narumi Uno, Teruhiko Suzuki, Satoshi Abe, Masaki Sugawara, Yuichi Nagashima, Kanako Kazuki, Takeshi Endo, Kyotaro Yamazaki, Wakana Nakagawa, Reika Yuno, Yui Moriguchi, Satoko Matsukura, Kazuma Tomizuka, Yasuhiro Kazuki
Scientific reports 15(1)
2025-07-30
DOI:
10.1038/s41598-025-13138-5
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Double-humanized Rats for CYP3A and PXR as an Improved Model for Analyzing Drug-drug Interactions Mediated by CYP3A4.
Kaoru Kobayashi, Genki Minegishi, Kanako Kazuki, Satoshi Abe, Miyuki Sato, Atsushi Miyajima, Masumi Hirabayashi, Tetsushi Sakuma, Takashi Yamamoto, Yasuhiro Kazuki
The AAPS journal 27(5)
2025-07-28
DOI:
10.1208/s12248-025-01111-z
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Genetic variation and genome-wide association analysis of nitrogen use efficiency-related traits under combined heat and nitrogen-deficient stress in an Aegilops tauschii-derived wheat population
Amir Ibrahim Ismail Emam, Izzat Sidahmed Ali Tahir, Nasrein Mohamed Kamal, Yasir Serag Alnor Gorafi, Hisashi Tsujimoto, Takayoshi Ishii
Frontiers in Plant Science
2025-07-16
DOI:
10.3389/fpls.2025.1621916
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Ectopic ULBP2 Is Associated with Decreased NKG2D Expression in CD8+ T Cells Under T Cell-Modulatory Conditions in a Murine Tumor Model.
Yasuhiko Teruya, Kosuke Yamaguchi, Kohei Yamane, Naomi Miyake, Yuji Nakayama, Takafumi Nonaka, Hiroki Chikumi, Akira Yamasaki
Cells 14(12)
2025-06-13
DOI:
10.3390/cells14120893
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Local Deformation in Phase-Separated Giant Liposomes via Photo-Induced Peptide Nanofiber Formation
Yingbing Liang, Yasunari Takaki, Hiroshi Inaba, Kazunori Matsuura
Langmuir
2025-06-04
DOI:
10.1021/acs.langmuir.5c01634
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ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates
Yusen Men, Shoshiro Hirayama, Shinpei Ao, Yasuyuki Sakurai, Yuri Shibata, Megan Lo, Yusuke Sato, Shigeo Murata
Journal of Cell Biology
2025-06-02
DOI:
10.1083/jcb.202406120
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Adaptor-Specific Peptide Inhibitors of the Ubiquitin-Chain-Dependent Unfolding Activity of the Human p97(VCP)–UFD1–NPL4 Complex
Kei Okatsu, Takaya Kawaguchi, Kohei Watanabe, Yoshinori Taguchi, Reon Takeuchi, Akinori Okamoto, Yasuyuki Iwasa, Takuya Tomita, Yasushi Saeki, Yusuke Sato, Tetsuo Narumi, Shuya Fukai
Journal of Medicinal Chemistry 68(11)
2025-05-27
DOI:
10.1021/acs.jmedchem.5c00201
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Photomodulation of actin filaments using spiropyran-modified peptide nanofibers
Subhajit Guria, Yingbing Liang, Hiroshi Inaba, Kazunori Matsuura
Bulletin of the Chemical Society of Japan 98(6)
2025-05-16
DOI:
10.1093/bulcsj/uoaf045
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Antitumor Activity of Vebreltinib and Characterization of Clinicogenomic Features in Solid Tumors with MET Rearrangements
Seshiru Nakazawa, Federica Pecci, Igor Odintsov, Dimitris Gazgalis, Felix H. Gottlieb, Biagio Ricciuti, Lodovica Zullo, Joao V. Alessi, Alessandro Di Federico, Mihaela Aldea, Edoardo Garbo, Malini M. Gandhi, Arushi Saini, William W. Feng, Jie Jiang, Simon Baldacci, Francesco Facchinetti, Maisam Makarem, Marie-Anaïs Locquet, Koji Haratani, Danielle Haradon, Benjamin Besse, Antoine Italiano, Jordi Remon, Pernelle Lavaud, Damien Vasseur, David Planchard, Yusuke Sato, Yukako Watanabe, Scott Owen, Alexis B. Cortot, Hoda Mahran, Martin D. Forster, Jiaxin Niu, Pascale Tomasini, Swan Swan Leong, Kevin Tay, Emilio Esteban, Anna Minchom, Sani H. Kizilbash, Marcia Cruz-Correa, Kin-Hung Peony Yu, Xiaoling Zhang, Pan Chen, Mythili Sangem, Jianwei Che, Lynette M. Sholl, Pasi A. Jänne, Mark M. Awad
Cancer Discovery
2025-05-14
DOI:
10.1158/2159-8290.cd-24-1726
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Hepatic Stellate Cells Activated by Cancer Cell-derived AMIGO2-containing Small Extracellular Vesicles Promote Cancer Cell Migration by Producing IL-8.
Runa Izutsu, Mitsuhiko Osaki, Heekyung Seong, Reo Sato, Futoshi Okada
Anticancer research 45(4)
2025-04
DOI:
10.21873/anticanres.17528
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ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity.
Kohei Yamane, Kosuke Yamaguchi, Yasuhiko Teruya, Naomi Miyake, Yuji Nakayama, Takafumi Nonaka, Hiroki Chikumi, Akira Yamasaki
International journal of molecular sciences 26(7)
2025-03-24
DOI:
10.3390/ijms26072950
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Combinatorial ubiquitin code degrades deubiquitylation-protected substrates
Mai Morita, Miyu Takao, Honoka Tokuhisa, Ryotaro Chiba, Shota Tomomatsu, Yoshino Akizuki, Takuya Tomita, Akinori Endo, Yasushi Saeki, Yusuke Sato, Fumiaki Ohtake
Nature Communications 16(1)
2025-03-24
DOI:
10.1038/s41467-025-57873-9
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FRPR-1, a G protein-coupled receptor in the FMRFamide-related peptide receptor family, modulates larval development as a receptor candidate of the FMRFamide-like peptide FLP-1 in Caenorhabditis elegans
Risako Une, Riko Uegaki, Sho Maega, Masahiro Ono, Tomohiro Bito, Takashi Iwasaki, Akira Shiraishi, Honoo Satake, Tsuyoshi Kawano
Bioscience, Biotechnology, and Biochemistry 89(4)
2025-03-24
DOI:
10.1093/bbb/zbaf004
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Plasmodium falciparum histidine-rich protein 2 exhibits cell penetration and cytotoxicity with autophagy dysfunction
Takashi Iwasaki, Mayu Shimoda, Haru Kanayama, Tsuyoshi Kawano
Bioscience, Biotechnology, and Biochemistry 89(4)
2025-03-24
DOI:
10.1093/bbb/zbae209
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Structural and virological identification of neutralizing antibody footprint provides insights into therapeutic antibody design against SARS-CoV-2 variants.
Yuki Anraku, Shunsuke Kita, Taishi Onodera, Akihiko Sato, Takashi Tadokoro, Shiori Ito, Yu Adachi, Ryutaro Kotaki, Tateki Suzuki, Jiei Sasaki, Nozomi Shiwa-Sudo, Naoko Iwata-Yoshikawa, Noriyo Nagata, Souta Kobayashi, Yasuhiro Kazuki, Mitsuo Oshimura, Takao Nomura, Michihito Sasaki, Yasuko Orba, Tadaki Suzuki, Hirofumi Sawa, Takao Hashiguchi, Hideo Fukuhara, Yoshimasa Takahashi, Katsumi Maenaka
Communications biology 8(1)
2025-03-22
DOI:
10.1038/s42003-025-07827-0
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Peptide-mediated display of Tau-derived peptide for construction of microtubule superstructures
Hiroshi Inaba, Daichi Kageyama, Soei Watari, Mahoko Tateishi, Akira Kakugo, Kazunori Matsuura
RSC Chemical Biology 6
2025-03
DOI:
10.1039/d4cb00290c
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Cancer prevention: past challenges and future directions.
HeeKyung Seong, Runa Izutsu, Mitsuhiko Osaki, Futoshi Okada
Genes and environment : the official journal of the Japanese Environmental Mutagen Society 47(1)
2025-02-27
DOI:
10.1186/s41021-025-00326-y
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Enriched grain minerals in Aegilops tauschii-derived common wheat population under heat-stress environments
Amir Ibrahim Ismail Emam, Nasrein Mohamed Kamal, Yasir Serag Alnor Gorafi, Izzat Sidahmed Ali Tahir, Mohammed Yousif Balla, Hisashi Tsujimoto, Takayoshi Ishii
Scientific Reports 15(1)
2025-02-15
DOI:
10.1038/s41598-025-89144-4
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Development of an OATP1-humanized transchromosomic mouse model for prediction of hepatic drug uptake in humans.
Tomoki Koishikawa, Kanako Kazuki, Rina Ohnishi, Koki Okita, Tadahaya Mizuno, Satoshi Abe, Isamu Nanchi, Yusaku Masago, Kyotaro Yamazaki, Jun-Ichiro Ohzeki, Hiroyuki Kusuhara, Yasuhiro Kazuki
Drug metabolism and disposition: the biological fate of chemicals 53(2)
2025-02
DOI:
10.1016/j.dmd.2024.100028
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Optical Control of Microtubule Accumulation and Dispersion by Tau-Derived Peptide-Fused Photoresponsive Protein
Soei Watari, Hiroshi Inaba, Qianru H. Lv, Muneyoshi Ichikawa, Takashi Iwasaki, Bingxun Wang, Hisashi Tadakuma, Akira Kakugo, Kazunori Matsuura
JACS Au 5
2025-01-23
DOI:
10.1021/jacsau.4c01017
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Titin fragment is a sensitive biomarker in Duchenne muscular dystrophy model mice carrying full-length human dystrophin gene on human artificial chromosome.
Yosuke Hiramuki, Miwa Hosokawa, Kayo Osawa, Taku Shirakawa, Yasuhiro Watanabe, Ritsuko Hanajima, Hiroyuki Kugoh, Hiroyuki Awano, Masafumi Matsuo, Yasuhiro Kazuki
Scientific reports 15(1)
2025-01-13
DOI:
10.1038/s41598-025-85369-5
