研究成果
2014年
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A Novel and Stable Mouse Artificial Chromosome Vector
Masato Takiguchi, Yasuhiro Kazuki, Kei Hirarnatsu, Satoshi Abe, Yuichi Iida, Shoko Takehara, Tadashi Nishida, Tetsuya Ohbayashi, Teruhiko Wakayama, Mitsuo Oshimura
ACS SYNTHETIC BIOLOGY 3(12)
2014-12
DOI:
10.1021/sb3000723
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Proteoliposome-based Selection of a Recombinant Antibody Fragment Against the Human M2 Muscarinic Acetylcholine Receptor
Suharni, Yayoi Nomura, Takatoshi Arakawa, Tomoya Hino, Hitomi Abe, Yoshiko Nakada-Nakura, Yumi Sato, Hiroko Iwanari, Mitsunori Shiroishi, Hidetsugu Asada, Tatsuro Shimamura, Takeshi Murata, Takuya Kobayashi, Takao Hamakubo, So Iwata, Norimichi Nomura
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy 33(6)
2014-12
DOI:
10.1089/mab.2014.0041
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Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture
Akira Shimamoto, Harunobu Kagawa, Kazumasa Zensho, Yukihiro Sera, Yasuhiro Kazuki, Mitsuhiko Osaki, Mitsuo Oshimura, Yasuhito Ishigaki, Kanya Hamasaki, Yoshiaki Kodama, Shinsuke Yuasa, Keiichi Fukuda, Kyotaro Hirashima, Hiroyuki Seimiya, Hirofumi Koyama, Takahiko Shimizu, Minoru Takemoto, Koutaro Yokote, Makoto Goto, Hidetoshi Tahara
PLOS ONE 9(11)
2014-11
DOI:
10.1371/journal.pone.0112900
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A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome
Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura, Takahiko Hara
PLOS ONE 9(10)
2014-10
DOI:
10.1371/journal.pone.0110404
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Changes in genome-wide gene expression during allopolyploidization and genome stabilization in hexaploid wheat
Yeonju Jung, Kanako Kawaura, Kohei Mishina, Shun Sakuma, Masahiro Kishii, Yasunari Ogihara
GENES & GENETIC SYSTEMS 89(5)
2014-10
DOI:
10.1266/ggs.89.215
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Cytoplasmic maspin expression predicts poor prognosis of patients with soft tissue sarcomas.
Takeda C, Takagi Y, Shiomi T, Nosaka K, Yamashita H, Osaki M, Endo K, Minamizaki T, Teshima R, Nagashima H, Umekita Y
Diagnostic pathology 9
2014-10
DOI:
10.1186/s13000-014-0205-9
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ヒト口腔がん細胞株(HSC3)への正常3番染色体導入によるTERT発現抑制
西尾 幸与, 大平 崇人, 砂村 直洋, 小谷 勇, 押村 光雄, 領家 和男, 久郷 裕之
日本口腔科学会雑誌 63(4)
2014-09
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ヒト口腔がん細胞株(HSC3)への正常3番染色体導入によるTERT発現抑制(Repression hTERT transcription by chromosome 3 in human oral squamous cell carcinoma)
西尾 幸与, 大平 崇人, 砂村 直洋, 押村 光雄, 領家 和男, 久郷 裕之
日本癌学会総会記事 73回
2014-09
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Intracellular Protein Delivery System with Protein Needle-GFP Construct
Hiroshi Inaba, Nusrat J. M. Sanghamitra, Toshihiro Fukai, Takahiro Matsumoto, Kaname Nishijo, Shuji Kanamaru, Fumio Arisaka, Susumu Kitagawa, Takafumi Ueno
CHEMISTRY LETTERS 43(9)
2014-09
DOI:
10.1246/cl.140481
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Dual-Color Fluorescence Imaging to Monitor CYP3A4 and CYP3A7 Expression in Human Hepatic Carcinoma HepG2 and HepaRG Cells
Saori Tsuji, Fumihiko Kawamura, Musashi Kubiura, Ayaka Hayashi, Tetsuya Ohbayashi, Yasuhiro Kazuki, Christophe Chesne, Mitsuo Oshimura, Masako Tada
PLOS ONE 9(8)
2014-08
DOI:
10.1371/journal.pone.0104123
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Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies
Yasuhiro Kazuki, Yuwna Yakura, Satoshi Abe, Mitsuhiko Osaki, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Kazuhisa Honma, Hirofumi Suemori, Satoshi Yamazaki, Tetsushi Sakuma, Tsutomu Toki, Ritsuko Shimizu, Hiromitsu Nakauchi, Takashi Yamamoto, Mitsuo Oshimura
SCIENTIFIC REPORTS 4
2014-08
DOI:
10.1038/srep06136
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Structures of reduced and ligand-bound nitric oxide reductase provide insights into functional differences in respiratory enzymes
Nozomi Sato, Shoko Ishii, Hiroshi Sugimoto, Tomoya Hino, Yoshihiro Fukumori, Yoshihiko Sako, Yoshitsugu Shiro, Takehiko Tosha
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82(7)
2014-07
DOI:
10.1002/prot.24492
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Endoplasmic Reticulum-associated Degradation of Niemann-Pick C1 EVIDENCE FOR THE ROLE OF HEAT SHOCK PROTEINS AND IDENTIFICATION OF LYSINE RESIDUES THAT ACCEPT UBIQUITIN
Naoe Nakasone, Yuko S. Nakamura, Katsumi Higaki, Nao Oumi, Kousaku Ohno, Haruaki Ninomiya
JOURNAL OF BIOLOGICAL CHEMISTRY 289(28)
2014-07
DOI:
10.1074/jbc.M114.549915
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Molecular Basis of 1-Deoxygalactonojirimycin Arylthiourea Binding to Human alpha-Galactosidase A: Pharmacological Chaperoning Efficacy on Fabry Disease Mutants
Yi Yu, Teresa Mena-Barragan, Katsumi Higaki, Jennifer L. Johnson, Jason E. Drury, Raquel L. Lieberman, Naoe Nakasone, Haruaki Ninomiya, Takahiro Tsukimura, Hitoshi Sakuraba, Yoshiyuki Suzuki, Eiji Nanba, Carmen Ortiz Mellet, Jose M. Garcia Fernandez, Kousaku Ohno
ACS CHEMICAL BIOLOGY 9(7)
2014-07
DOI:
10.1021/cb500143h
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The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.
Adam L Knight, Xiaohui Yan, Shusei Hamamichi, Rami R Ajjuri, Joseph R Mazzulli, Mike W Zhang, J Gavin Daigle, Siyuan Zhang, Akeem R Borom, Lindsay R Roberts, S Kyle Lee, Susan M DeLeon, Coralie Viollet-Djelassi, Dimitri Krainc, Janis M O'Donnell, Kim A Caldwell, Guy A Caldwell
Cell metabolism 20(1)
2014-07-01
DOI:
10.1016/j.cmet.2014.04.017
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A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region
Shoko Takehara, Thomas C. Schulz, Satoshi Abe, Masato Takiguchi, Kanako Kazuki, Satoshi Kishigami, Teruhiko Wakayama, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
TRANSGENIC RESEARCH 23(3)
2014-06
DOI:
10.1007/s11248-014-9781-4
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SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors
Toshiaki Inoue, Yuji Nakayama, Yanze Li, Haruka Matsumori, Haruka Takahashi, Hirotada Kojima, Hideki Wanibuchi, Motonobu Katoh, Mitsuo Oshimura
FEBS JOURNAL 281(11)
2014-06
DOI:
10.1111/febs.12810
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QTL analysis of genetic loci affecting domestication-related spike characters in common wheat
Mazen Katkout, Masahiro Kishii, Kanako Kawaura, Kouhei Mishina, Shun Sakuma, Kazuko Umeda, Shigeo Takumi, Miyuki Nitta, Shuhei Nasuda, Yasunari Ogihara
GENES & GENETIC SYSTEMS 89(3)
2014-06
DOI:
10.1266/ggs.89.121
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A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells (vol 9, e88530, 2014)
M. Wakai
PLOS ONE 9(5)
2014-05
DOI:
10.1371/journal.pone.0098825
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Presence of Epstein-Barr virus-infected B lymphocytes with thyrotropin receptor antibodies on their surface in Graves' disease patients and in healthy individuals
Keiko Nagata, Katsumi Higaki, Yuji Nakayama, Hiromi Miyauchi, Yui Kiritani, Kyosuke Kanai, Michiko Matsushita, Takeshi Iwasaki, Hirotsugu Sugihara, Satoshi Kuwamoto, Masako Kato, Ichiro Murakami, Eiji Nanba, Hiroshi Kimura, Kazuhiko Hayashi
AUTOIMMUNITY 47(3)
2014-05
DOI:
10.3109/08916934.2013.879863
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Switching and emergence of CTL epitopes in HIV-1 infection
Chungyong Han, Ai Kawana-Tachikawa, Akihisa Shimizu, Dayong Zhu, Hitomi Nakamura, Eisuke Adachi, Tadashi Kikuchi, Michiko Koga, Tomohiko Koibuchi, George F. Gao, Yusuke Sato, Atsushi Yamagata, Eric Martin, Shuya Fukai, Zabrina L. Brumme, Aikichi Iwamoto
RETROVIROLOGY 11
2014-05
DOI:
10.1186/1742-4690-11-38
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Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis
Kanda Y, Kawaguchi T, Kuramitsu Y, Kitagawa T, Kobayashi T, Takahashi N, Tazawa H, Habelhah H, Hamada J.-I, Kobayashi M, Hirahata M, Onuma K, Osaki M, Nakamura K, Kitagawa T, Hosokawa M, Okada F
Proteomics 14(9)
2014-05
DOI:
10.1002/pmic.201300414
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How to eliminate a partner for good
Takayoshi Ishii, Andreas Houben
CELL CYCLE 13(9)
2014-05
DOI:
10.4161/cc.28752
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Circulating microRNAs in drug safety assessment for hepatic and cardiovascular toxicity: The latest biomarker frontier?
Osaki M, Kosaka N, Okada F, Ochiya T
Molecular Diagnosis and Therapy 18(2)
2014-04
DOI:
10.1007/s40291-013-0065-0
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Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan.
Watanabe M, Kurai J, Tomita K, Sano H, Abe S, Saito R, Minato S, Igishi T, Burioka N, Sako T, Yasuda K, Mikami M, Kurita S, Tokuyasu H, Ueda Y, Konishi T, Yamasaki A, Aiba S, Oshimura M, Shimizu E
The Journal of asthma : official journal of the Association for the Care of Asthma
2014-03-27
DOI:
10.3109/02770903.2014.903965
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Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.
Kent E S Matlack, Daniel F Tardiff, Priyanka Narayan, Shusei Hamamichi, Kim A Caldwell, Guy A Caldwell, Susan Lindquist
Proceedings of the National Academy of Sciences of the United States of America 111(11)
2014-03-18
DOI:
10.1073/pnas.1402228111
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PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia
Motoki Nakabayashi, Mitsuhiko Osaki, Isamu Kodani, Futoshi Okada, Kazuo Ryoke, Mitsuo Oshimura, Hisao Ito, Hiroyuki Kugoh
ONCOLOGY LETTERS 7(3)
2014-03
DOI:
10.3892/ol.2013.1775
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Bi-HAC Vector System toward Gene and Cell Therapy
Yuichi Iida, Yasuhiro Kazuki, Masahiro Hayashi, Yasuji Ueda, Mamoru Hasegawa, Natalay Kouprina, Vladimir Larionov, Mitsuo Oshimura
ACS SYNTHETIC BIOLOGY 3(2)
2014-02
DOI:
10.1021/sb400166j
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A Human Artificial Chromosome Recapitulates the Metabolism of Native Telomeres in Mammalian Cells
Michihito Wakai, Satoshi Abe, Yasuhiro Kazuki, Mitsuo Oshimura, Fuyuki Ishikawa
PLOS ONE 9(2)
2014-02
DOI:
10.1371/journal.pone.0088530
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Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.
Fernando Muñoz-Lobato, María Jesús Rodríguez-Palero, Francisco José Naranjo-Galindo, Freya Shephard, Christopher J Gaffney, Nathaniel J Szewczyk, Shusei Hamamichi, Kim A Caldwell, Guy A Caldwell, Chris D Link, Antonio Miranda-Vizuete
Antioxidants & redox signaling 20(2)
2014-01-10
DOI:
10.1089/ars.2012.5051
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Complete restoration of multiple dystrophin isoforms in genetically corrected Duchenne muscular dystrophy patient-derived cardiomyocytes
Susi Zatti, Sebastian Martewicz, Elena Serena, Narumi Uno, Giovanni Giobbe, Yasuhiro Kazuki, Mitsuo Oshimura, Nicola Elvassore
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 1
2014
DOI:
10.1038/mtm.2013.1
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Plasma membrane translocation of a protein needle based on a triple-stranded beta-helix motif
Nusrat J. M. Sanghamitra, Hiroshi Inaba, Fumio Arisaka, Dan Ohtan Wang, Shuji Kanamaru, Susumu Kitagawa, Takafumi Ueno
MOLECULAR BIOSYSTEMS 10(10)
2014
DOI:
10.1039/c4mb00293h
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Influence of Npc1 genotype on the toxicity of hydroxypropyl-β- cyclodextrin, a potentially therapeutic agent, in Niemann-Pick Type C disease models
Yuta Tanaka, Yoichi Ishitsuka, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
Molecular Genetics and Metabolism Reports 1(1)
2014
DOI:
10.1016/j.ymgmr.2013.12.003
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Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier
Julio Rodriguez-Lavado, Mario de la Mata, Jose L. Jimenez-Blanco, M. Isabel Garcia-Moreno, Juan M. Benito, Antonio Diaz-Quintana, Jose A. Sanchez-Alcazar, Katsumi Higaki, Eiji Nanba, Kousaku Ohno, Yoshiyuki Suzuki, Carmen Ortiz Mellet, Jose M. Garcia Fernandez
ORGANIC & BIOMOLECULAR CHEMISTRY 12(14)
2014
DOI:
10.1039/c3ob42530d
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Structural basis of pharmacological chaperones for human β-galactosidase.
Suzuki H, Ohto U, Higaki K, Mena-Barragan T, Aguilar-Moncayo M, Ortiz Mellet C, Nanba E, Garcia Fernandez JM, Suzuki Y, Shimizu T
J Biol Chem 289
2014
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Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma
Hideto Iwamoto, Yusuke Kanda, Takehiro Sejima, Mitsuhiko Osaki, Futoshi Okada, Atsushi Takenaka
INTERNATIONAL JOURNAL OF ONCOLOGY 44(1)
2014-01
DOI:
10.3892/ijo.2013.2169
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Recovery correction technique for NMR spectroscopy of perchloric acid extracts using DL-valine-2,3-d2: validation and application to 5-fluorouracil-induced brain damage.
Ryutaro Nakagami, Masayuki Yamaguchi, Kenji Ezawa, Sadaaki Kimura, Shusei Hamamichi, Norio Sekine, Akira Furukawa, Mamoru Niitsu, Hirofumi Fujii
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 13(3)
2014
