研究成果
2020年
-
micro RNAによる腎癌の早期診断およびスニチニブ耐性に関する検討
弓岡 徹也, 寺岡 祥吾, 西川 涼馬, 木村 有祐, 岩本 秀人, 森實 修一, 引田 克弥, 尾崎 充彦, 本田 正史, 岡田 太, 武中 篤
日本泌尿器科学会総会 108回
2020-12
-
Unequal contribution of two paralogous CENH3 variants in cowpea centromere function
Ishii, T., Jurani?, M., Maheshwari, S., Bustamante, F.O., Vogt, M., Salinas-Gamboa, R., Dreissig, S., Gursanscky, N., How, T., Demidov, D., Fuchs, J., Schubert, V., Spriggs, A., Vielle-Calzada, J.-P., Comai, L., Koltunow, A.M.G., Houben, A.
Communications Biology 3(1)
2020-12
DOI:
10.1038/s42003-020-01507-x
-
A polylysine–polyhistidine fusion peptide for lysosome-targeted protein delivery
Takashi Iwasaki, Nodoka Murakami, Tsuyoshi Kawano
Biochemical and Biophysical Research Communications 533(4)
2020-12
DOI:
10.1016/j.bbrc.2020.09.087
-
Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia
Kenjirou Ogawa, Ayumi Ishii, Aimi Shindo, Kunihiro Hongo, Tomohiro Mizobata, Tetsuya Sogon, Yasushi Kawata
Nutrients 12(11)
2020-11-13
DOI:
10.3390/nu12113480
-
Horseradish Peroxidase-Decorated Artificial Viral Capsid Constructed from β-Annulus Peptide via Interaction between His-Tag and Ni-NTA
Kazunori Matsuura, Yuriko Shiomi, Toshihumi Mizuta, Hiroshi Inaba
Processes 8(11)
2020-11-13
DOI:
10.3390/pr8111455
-
Encapsulation of mRNA into Artificial Viral Capsids via Hybridization of a β-Annulus-dT20 Conjugate and the Poly(A) Tail of mRNA
Yoko Nakamura, Yuki Sato, Hiroshi Inaba, Takashi Iwasaki, Kazunori Matsuura
Applied Sciences 10(22)
2020-11-12
DOI:
10.3390/app10228004
-
Applicability of Styrene-Maleic Acid Copolymer for Two Microbial Rhodopsins, RxR and HsSRI.
Tetsuya Ueta, Keiichi Kojima, Tomoya Hino, Mikihiro Shibata, Shingo Nagano, Yuki Sudo
Biophysical journal 119(9)
2020-11-03
DOI:
10.1016/j.bpj.2020.09.026
-
Splice variants of lysosome‑associated membrane proteins 2A and 2B are involved in sunitinib resistance in human renal cell carcinoma cells.
Ryoma Nishikawa, Mitsuhiko Osaki, Ryo Sasaki, Mizuho Ishikawa, Tetsuya Yumioka, Noriya Yamaguchi, Hideto Iwamoto, Masashi Honda, Tomohiro Kabuta, Atsushi Takenaka, Futoshi Okada
Oncology reports 44(5)
2020-11
DOI:
10.3892/or.2020.7752
-
細胞遺伝学の新潮流―より速く， より広く，より細かく，そして創出へ 古くて新しいゲノムの見える化技術
石井孝佳, 長岐清孝, 菊池真司
化学と生物 Vol.58(No.11)
2020-11
-
Meganuclease-Based Artificial Transcription Factors.
Shingo Suzuki, Ken-Ichi Ohta, Yoshihiro Nakajima, Hajime Shigeto, Hiroko Abe, Anna Kawai, Ryuichiro Miura, Yasuhiro Kazuki, Mitsuo Oshimura, Takanori Miki
ACS synthetic biology 9(10)
2020-10-16
DOI:
10.1021/acssynbio.0c00083
-
Immunotoxin Screening System: A Rapid and Direct Approach to Obtain Functional Antibodies with Internalization Capacities.
Shusei Hamamichi, Takeshi Fukuhara, Nobutaka Hattori
Toxins 12(10)
2020-10-15
DOI:
10.3390/toxins12100658
-
Real-time fluorometric evaluation of hepatoblast proliferation in vivo and in vitro using the expression of CYP3A7 coding for human fetus-specific P450.
Shota Okuyama, Fumihiko Kawamura, Musashi Kubiura, Saori Tsuji, Mitsuhiko Osaki, Hiroyuki Kugoh, Mitsuo Oshimura, Yasuhiro Kazuki, Masako Tada
Pharmacology research & perspectives 8(5)
2020-10
DOI:
10.1002/prp2.642
-
Establishment of human immortalized mesenchymal stem cells lines for the monitoring and analysis of osteogenic differentiation in living cells.
Takashi Narai, Ryohei Watase, Yuji Nakayama, Isamu Kodani, Toshiaki Inoue, Kenji Kokura
Heliyon 6(10)
2020-10
DOI:
10.1016/j.heliyon.2020.e05398
-
Cyclic Tau-derived peptides for stabilization of microtubules
Hiroshi Inaba, Miyuu Nagata, Kyeongmi Juliano Miyake, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
Polymer Journal 52(9)
2020-09
DOI:
10.1038/s41428-020-0356-3
-
ケモテクノロジーが拓くユビキチンニューフロンティア ヒトDUBアレイ技術を用いたUSP特異的阻害剤の開発
高橋 宏隆, 山中 聡士, 桑田 翔平, 檜垣 佳奈, 佐藤 裕介, 深井 周也, 徳永 文稔, 澤崎 達也
日本生化学会大会プログラム・講演要旨集 93回
2020-09
-
Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice
Mami Sato, Kunishige Onuma, Mio Domon, Shun Hasegawa, Ami Suzuki, Ryosuke Kusumi, Remi Hino, Nahoko Kakihara, Yusuke Kanda, Mitsuhiko Osaki, Junichi Hamada, Shiro Bannai, Regina Feederle, Katalin Buday, José Pedro Friedmann Angeli, Bettina Proneth, Marcus Conrad, Futoshi Okada, Hideyo Sato
International Journal of Cancer
2020-08-26
DOI:
10.1002/ijc.33262
-
Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome.
Yumi Ohta, Kanako Kazuki, Satoshi Abe, Mitsuo Oshimura, Kaoru Kobayashi, Yasuhiro Kazuki
BMC biotechnology 20(1)
2020-08-20
DOI:
10.1186/s12896-020-00637-8
-
Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.
Choong-Soo Yun, Kazuki Nishimoto, Takayuki Motoyama, Takeshi Shimizu, Tomoya Hino, Naoshi Dohmae, Shingo Nagano, Hiroyuki Osada
The Journal of biological chemistry 295(33)
2020-08-14
DOI:
10.1074/jbc.RA120.013105
-
CENP-B creates alternative epigenetic chromatin states permissive for CENP-A or heterochromatin assembly.
Koichiro Otake, Jun-Ichirou Ohzeki, Nobuaki Shono, Kazuto Kugou, Koei Okazaki, Takahiro Nagase, Hisashi Yamakawa, Natalay Kouprina, Vladimir Larionov, Hiroshi Kimura, William C Earnshaw, Hiroshi Masumoto
Journal of cell science 133(15)
2020-08-11
DOI:
10.1242/jcs.243303
-
Biomechanical Properties and Agro-Morphological Traits for Improved Lodging Resistance in Ethiopian Teff (Eragrostis tef (Zucc.) Trottor) Accessions
Muluken Bayable, Atsushi Tsunekawa, Nigussie Haregeweyn, Takayoshi Ishii, Getachew Alemayehu, Mitsuru Tsubo, Enyew Adgo, Asaminew Tassew, Wataru Tsuji, Fekremariam Asaregew, Tsugiyuki Masunaga
Agronomy 10(7)
2020-07-14
DOI:
10.3390/agronomy10071012
-
Magnetic Force-Induced Alignment of Microtubules by Encapsulation of CoPt Nanoparticles Using a Tau-Derived Peptide
Hiroshi Inaba, Mayuki Yamada, Mst. Rubaya Rashid, Arif Md. Rashedul Kabir, Akira Kakugo, Kazuki Sada, Kazunori Matsuura
Nano Letters 20(7)
2020-07-08
DOI:
10.1021/acs.nanolett.0c01573
-
Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells.
Yuichi Iida, Rintaro Yoshikawa, Akihiko Murata, Hitoshi Kotani, Yasuhiro Kazuki, Mitsuo Oshimura, Yumi Matsuzaki, Mamoru Harada
Journal for immunotherapy of cancer 8(2)
2020-07
DOI:
10.1136/jitc-2020-000582
-
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism.
Hiroto Shimada, Tsukasa Kusakizako, T H Dung Nguyen, Tomohiro Nishizawa, Tomoya Hino, Makoto Tominaga, Osamu Nureki
Nature structural & molecular biology 27(7)
2020-07
DOI:
10.1038/s41594-020-0439-z
-
A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21
Yasuhiro Kazuki, Feng J Gao, Yicong Li, Anna J Moyer, Benjamin Devenney, Kei Hiramatsu, Sachiko Miyagawa-Tomita, Satoshi Abe, Kanako Kazuki, Naoyo Kajitani, Narumi Uno, Shoko Takehara, Masato Takiguchi, Miho Yamakawa, Atsushi Hasegawa, Ritsuko Shimizu, Satoko Matsukura, Naohiro Noda, Narumi Ogonuki, Kimiko Inoue, Shogo Matoba, Atsuo Ogura, Liliana D Florea, Alena Savonenko, Meifang Xiao, Dan Wu, Denise AS Batista, Junhua Yang, Zhaozhu Qiu, Nandini Singh, Joan T Richtsmeier, Takashi Takeuchi, Mitsuo Oshimura, Roger H Reeves
eLife 9
2020-06-29
DOI:
10.7554/elife.56223
-
Immunological Evaluation of Co-assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants as Self-adjuvanting Anti-breast Cancer Vaccine Candidates.
Taku Aiga, Yoshiyuki Manabe, Keita Ito, Tsung-Che Chang, Kazuya Kabayama, Shino Ohshima, Yoshie Kametani, Ayane Miura, Hiroto Furukawa, Hiroshi Inaba, Kazunori Matsuura, Koichi Fukase
Angewandte Chemie (International ed. in English) 59(40)
2020-06-24
DOI:
10.1002/anie.202007999
-
A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors.
Hirotaka Takahashi, Satoshi Yamanaka, Shohei Kuwada, Kana Higaki, Kohki Kido, Yusuke Sato, Shuya Fukai, Fuminori Tokunaga, Tatsuya Sawasaki
Biomedicines 8(6)
2020-06-04
DOI:
10.3390/biomedicines8060152
-
Heat sensing and lipid reprograming as a signaling switch for heat stress responses in wheat
Abdelrahman, M., Ishii, T., El-Sayed, M., Tran, L.-S.P.
Plant and Cell Physiology 61(8)
2020-05-28
DOI:
10.1093/pcp/pcaa072
-
Transchromosomic technology for genomically humanized animals.
Takashi Moriwaki, Satoshi Abe, Mitsuo Oshimura, Yasuhiro Kazuki
Experimental cell research 390(2)
2020-05-15
DOI:
10.1016/j.yexcr.2020.111914
-
Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders.
Daisuke Oikawa, Yusuke Sato, Hidefumi Ito, Fuminori Tokunaga
International journal of molecular sciences 21(9)
2020-05-11
DOI:
10.3390/ijms21093381
-
Current advances in microcell-mediated chromosome transfer technology and its applications
Teruhiko Suzuki, Yasuhiro Kazuki, Takahiko Hara, Mitsuo Oshimura
Experimental Cell Research 390(1)
2020-05
DOI:
10.1016/j.yexcr.2020.111915
-
Down syndrome-related transient abnormal myelopoiesis is attributed to a specific erythro-megakaryocytic subpopulation with GATA1 mutation.
Yoko Nishinaka-Arai, Akira Niwa, Shiori Matsuo, Yasuhiro Kazuki, Yuwna Yakura, Takehiko Hiroma, Tsutomu Toki, Tetsushi Sakuma, Takashi Yamamoto, Etsuro Ito, Mitsuo Oshimura, Tatsutoshi Nakahata, Megumu K Saito
Haematologica 106(2)
2020-04-30
DOI:
10.3324/haematol.2019.242693
-
A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus.
Ryutaro Shirakawa, Sakurako Goto-Ito, Kota Goto, Shonosuke Wakayama, Haremaru Kubo, Natsumi Sakata, Duc Anh Trinh, Atsushi Yamagata, Yusuke Sato, Hiroshi Masumoto, Jinglei Cheng, Toyoshi Fujimoto, Shuya Fukai, Hisanori Horiuchi
The EMBO journal 39(8)
2020-04-15
DOI:
10.15252/embj.2019104120
-
Human artificial chromosome: Chromatin assembly mechanisms and CENP-B.
Jun-Ichirou Ohzeki, Koichiro Otake, Hiroshi Masumoto
Experimental cell research 389(2)
2020-04-15
DOI:
10.1016/j.yexcr.2020.111900
-
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, Keidai Komakura, Kazuki Hanada, Koji Sugawara, Seigo Terawaki, Yukari Mizukami, Hoang T Phuong, Kiyosei Iio, Shingo Obika, Masaya Fukushi, Takashi Irie, Daisuke Tsuruta, Shinji Sakamoto, Keiji Tanaka, Yasushi Saeki, Shuya Fukai, Fuminori Tokunaga
Communications biology 3(1)
2020-04-03
DOI:
10.1038/s42003-020-0882-8
-
Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
Satoshi Yamanaka, Yusuke Sato, Daisuke Oikawa, Eiji Goto, Shuya Fukai, Fuminori Tokunaga, Hirotaka Takahashi, Tatsuya Sawasaki
Biochemical and biophysical research communications 524(1)
2020-03-26
DOI:
10.1016/j.bbrc.2019.12.049
-
Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain
Yasushi Yabuki, Kazuya Matsuo, Ichiro Kawahata, Naoya Fukui, Tomohiro Mizobata, Yasushi Kawata, Yuji Owada, Norifumi Shioda, Kohji Fukunaga
International Journal of Molecular Sciences
2020-03-23
DOI:
10.3390/ijms21062230
-
Increased PD-1-positive macrophages in the tissue of gastric cancer are closely associated with poor prognosis in gastric cancer patients
Yusuke Kono, Hiroaki Saito, Wataru Miyauchi, Shota Shimizu, Yuki Murakami, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Yuji Nakayama, Chiye Sakurai, Kiyotaka Hatsuzawa, Yoshiyuki Fujiwara
BMC CANCER 20(1)
2020-03
DOI:
10.1186/s12885-020-6629-6
-
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
Alexander M Wolff, Iris D Young, Raymond G Sierra, Aaron S Brewster, Michael W Martynowycz, Eriko Nango, Michihiro Sugahara, Takanori Nakane, Kazutaka Ito, Andrew Aquila, Asmit Bhowmick, Justin T Biel, Sergio Carbajo, Aina E Cohen, Saul Cortez, Ana Gonzalez, Tomoya Hino, Dohyun Im, Jake D Koralek, Minoru Kubo, Tomas S Lazarou, Takashi Nomura, Shigeki Owada, Avi J Samelson, Tomoyuki Tanaka, Rie Tanaka, Erin M Thompson, Henry van den Bedem, Rahel A Woldeyes, Fumiaki Yumoto, Wei Zhao, Kensuke Tono, Sebastien Boutet, So Iwata, Tamir Gonen, Nicholas K Sauter, James S Fraser, Michael C Thompson
IUCrJ 7(Pt 2)
2020-03-01
DOI:
10.1107/S205225252000072X
-
Application and prospects of CRISPR/Cas9-based methods to trace defined genomic sequences in living and fixed plant cells
Khosravi, S., Ishii, T., Dreissig, S., Houben, A.
Chromosome Research 28(1)
2020-03
DOI:
10.1007/s10577-019-09622-0
-
Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly.
Kazunori Matsuura, Junpei Ota, Seiya Fujita, Yuriko Shiomi, Hiroshi Inaba
The Journal of organic chemistry 85(3)
2020-02-07
DOI:
10.1021/acs.joc.9b02295
-
A novel Xist RNA-mediated chromosome inactivation model using a mouse artificial chromosome.
Daigo Inaoka, Naohiro Sunamura, Takahito Ohira, Yuji Nakayama, Hiroyuki Kugoh
Biotechnology letters
2020-01-31
DOI:
10.1007/s10529-020-02826-z
-
Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α.
Maiko Wakita, Atsushi Yamagata, Tomoko Shiroshima, Hironori Izumi, Asami Maeda, Mizuki Sendo, Ayako Imai, Keiko Kubota, Sakurako Goto-Ito, Yusuke Sato, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai
Nature communications 11(1)
2020-01-31
DOI:
10.1038/s41467-020-14516-5
-
Enveloped artificial viral capsids self-assembled from anionic β-annulus peptide and cationic lipid bilayer
Hiroto Furukawa, Hiroshi Inaba, Fumihito Inoue, Yoshihiro Sasaki, Kazunari Akiyoshi, Kazunori Matsuura
Chemical Communications 56(52)
2020
DOI:
10.1039/d0cc02622k
