研究成果
2016年
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Effects of duration of electric pulse on in vitro development of cloned cat embryos with human artificial chromosome vector
L. T.K. Do, M. Wittayarat, T. Terazono, Y. Sato, M. Taniguchi, F. Tanihara, T. Takemoto, Y. Kazuki, K. Kazuki, M. Oshimura, T. Otoi
Reproduction in Domestic Animals 51(6)
2016-12-01
DOI:
10.1111/rda.12766
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Analysis of grain elements and identification of best genotypes for Fe and P in Afghan wheat landraces.
Youichi Kondou, Alagu Manickavelu, Kenji Komatsu, Mujiburahman Arifi, Mika Kawashima, Takayoshi Ishii, Tomohiro Hattori, Hiroyoshi Iwata, Hisashi Tsujimoto, Tomohiro Ban, Minami Matsui
Breeding science 66(5)
2016-12
DOI:
10.1270/jsbbs.16041
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Five factors can reconstitute all three phases of microtubule polymerization dynamics.
Takashi Moriwaki, Gohta Goshima
The Journal of cell biology 215(3)
2016-11-07
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The effect of supplementation of amino acids and taurine to modified KSOM culture medium on rat embryo development
Kazuomi Nakamura, Kayoko Morimoto, Kaoru Shima, Yuki Yoshimura, Yasuhiro Kazuki, Osamu Suzuki, Junichiro Matsuda, Tetsuya Ohbayashi
THERIOGENOLOGY 86(8)
2016-11
DOI:
10.1016/j.theriogenology.2016.07.001
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Modulating the Effects of the Bacterial Chaperonin GroEL on Fibrillogenic Polypeptides through Modification of Domain Hinge Architecture
Naoya Fukui, Kiho Araki, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
JOURNAL OF BIOLOGICAL CHEMISTRY 291(48)
2016-11
DOI:
10.1074/jbc.M116.751925
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Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate
Mari Hashimoto, Kaoru Kobayashi, Mana Yamazaki, Yasuhiro Kazuki, Shoko Takehara, Mitsuo Oshimura, Kan Chiba
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 163
2016-10
DOI:
10.1016/j.jsbmb.2016.04.018
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Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Yuji Shiba, Toshihito Gomibuchi, Tatsuichiro Seto, Yuko Wada, Hajime Ichimura, Yuki Tanaka, Tatsuki Ogasawara, Kenji Okada, Naoko Shiba, Kengo Sakamoto, Daisuke Ido, Takashi Shiina, Masamichi Ohkura, Junichi Nakai, Narumi Uno, Yasuhiro Kazuki, Mitsuo Oshimura, Itsunari Minami, Uichi Ikeda
NATURE 538(7625)
2016-10
DOI:
10.1038/nature19815
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A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells
Kenji Kokura, Yasushi Kuromi, Takeshi Endo, Naohiko Anzai, Yasuhiro Kazuki, Mitsuo Oshimura, Tetsuya Ohbayashi
JOURNAL OF GENE MEDICINE 18(10)
2016-10
DOI:
10.1002/jgm.2925
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長鎖非コードRNA KCNQ1OT1/LIT1の発現動態が関わる大腸がん発がん機構の解明
久郷 裕之, 片岡 美喜, 稲岡 大悟, 押村 光雄, 田辺 秀之, 大平 崇人
日本癌学会総会記事 75回
2016-10
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Inhibitor versus chaperone behaviour of D-fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts
Teresa Mena-Barragan, M. Isabel Garcia-Moreno, Eiji Nanba, Katsumi Higaki, Alda Lisa Concia, Pere Clapes, Jose Manuel Garcia Fernandez, Carmen Ortiz Mellet
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 121
2016-10
DOI:
10.1016/j.ejmech.2015.08.038
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Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme
Alex de la Fuente, Rocio Risquez-Cuadro, Xavier Verdaguer, Jose M. Garcia Fernandez, Eiji Nanba, Katsumi Higaki, Carmen Ortiz Mellet, Antoni Riera
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 121
2016-10
DOI:
10.1016/j.ejmech.2015.10.038
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Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation.
Shunsuke Kimura, Masami Yamashita, Megumi Yamakami-Kimura, Yusuke Sato, Atsushi Yamagata, Yoshihiro Kobashigawa, Fuyuhiko Inagaki, Takako Amada, Koji Hase, Toshihiko Iwanaga, Hiroshi Ohno, Shuya Fukai
Scientific reports 6
2016-09-15
DOI:
10.1038/srep33548
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Wheat yellow mosaic virus resistance in wheat cultivar Madsen acts in roots but not in leaves
Cheng Liu, Takako Suzuki, Kohei Mishina, Antje Habekuss, Angelika Ziegler, Chao Li, Shun Sakuma, Guoxiong Chen, Mohammad Pourkheirandish, Takao Komatsuda
JOURNAL OF GENERAL PLANT PATHOLOGY 82(5)
2016-09
DOI:
10.1007/s10327-016-0674-7
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Tissue-specific genome instability in synthetic interspecific hybrids of Pennisetum purpureum (Napier grass) and Pennisetum glaucum (pearl millet) is caused by micronucleation
Gabriela Barreto dos Reis, Takayoshi Ishii, Joerg Fuchs, Andreas Houben, Lisete Chamma Davide
CHROMOSOME RESEARCH 24(3)
2016-09
DOI:
10.1007/s10577-016-9521-0
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Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry
Hiroshi Yamazaki, Hiroshi Suemizu, Yasuhiro Kazuki, Ken Oofusa, Shunji Kuribayashi, Makiko Shimizu, Shinichi Ninomiya, Toru Horie, Norio Shibata, F. Peter Guengerich
CHEMICAL RESEARCH IN TOXICOLOGY 29(8)
2016-08
DOI:
10.1021/acs.chemrestox.6b00210
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Suppression of amyloid fibrils using the GroEL apical domain
Bimlesh Ojha, Naoya Fukui, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
Scientific Reports 6
2016-08
DOI:
10.1038/srep31041
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PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma.
Masao Takenobu, Mitsuhiko Osaki, Kazunori Fujiwara, Takahiro Fukuhara, Hiroya Kitano, Hiroyuki Kugoh, Futoshi Okada
Molecular and clinical oncology 5(1)
2016-07
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In vitro evaluation of 2-hydroxyalkylated beta-cyclodextrins as potential therapeutic agents for Niemann-Pick Type C disease
Yuki Kondo, Hiroko Tokumaru, Yoichi Ishitsuka, Tomoko Matsumoto, Makiko Taguchi, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Tetsumi Irie
MOLECULAR GENETICS AND METABOLISM 118(3)
2016-07
DOI:
10.1016/j.ymgme.2016.04.014
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Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model
In Young Choi, HoTae Lim, Kenneth Estrellas, Jyothi Mula, Tatiana V. Cohen, Yuanfan Zhang, Christopher J. Donnelly, Jean-Philippe Richard, Yong Jun Kim, Hyesoo Kim, Yasuhiro Kazuki, Mitsuo Oshimura, Hongmei Lisa Li, Akitsu Hotta, Jeffrey Rothstein, Nicholas Maragakis, Kathryn R. Wagner, Gabsang Lee
CELL REPORTS 15(10)
2016-06
DOI:
10.1016/j.celrep.2016.05.016
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Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins
Teruhiko Suzuki, Yasuhiro Kazuki, Mitsuo Oshimura, Takahiko Hara
PLOS ONE 11(6)
2016-06
DOI:
10.1371/journal.pone.0157187
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Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity
Takeshi Endo, Natsumi Noda, Yasushi Kuromi, Kenji Kokura, Yasuhiro Kazuki, Mitsuo Oshimura, Tetsuya Ohbayashi
YONAGO ACTA MEDICA 59(2)
2016-06
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Prion Protein and Stage Specific Embryo Antigen 1 as Selection Markers to Enrich the Fraction of Murine Embryonic Stem Cell-Derived Cardiomyocytes
Nobuhito Ikeda, Yuji Nakayama, Natsumi Nakazawa, Akio Yoshida, Haruaki Ninomiya, Yasuaki Shirayoshi
YONAGO ACTA MEDICA 59(2)
2016-06
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KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation
Jun-ichirou Ohzeki, Nobuaki Shono, Koichiro Otake, Nuno M. C. Martins, Kazuto Kugou, Hiroshi Kimura, Takahiro Nagase, Vladimir Larionov, William C. Earnshaw, Hiroshi Masumoto
DEVELOPMENTAL CELL 37(5)
2016-06
DOI:
10.1016/j.devcel.2016.05.006
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A high number of IgG4-positive cells in gastric cancer tissue is associated with tumor progression and poor prognosis
Kozo Miyatani, Hiroaki Saito, Yuki Murakami, Joji Watanabe, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Yuji Nakayama, Yoshihisa Umekita, Masahide Ikeguchi
VIRCHOWS ARCHIV 468(5)
2016-05
DOI:
10.1007/s00428-016-1914-0
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Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons
Yuji Nakayama, Toshiaki Inoue
MOLECULES 21(5)
2016-05
DOI:
10.3390/molecules21050663
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PAI-1, a target gene of miR-143, regulates invasion and metastasis by upregulating MMP-13 expression of human osteosarcoma
Mio Hirahata, Mitsuhiko Osaki, Yusuke Kanda, Yui Sugimoto, Yusuke Yoshioka, Nobuyoshi Kosaka, Fumitaka Takeshita, Tomohiro Fujiwara, Akira Kawai, Hisao Ito, Takahiro Ochiya, Futoshi Okada
CANCER MEDICINE 5(5)
2016-05
DOI:
10.1002/cam4.651
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Ambroxol chaperone therapy for neuronopathic Gaucher disease: A pilot study
Aya Narita, Kentarou Shirai, Shinji Itamura, Atsue Matsuda, Akiko Ishihara, Kumi Matsushita, Chisako Fukuda, Norika Kubota, Rumiko Takayama, Hideo Shigematsu, Anri Hayashi, Tomohiro Kumada, Kotaro Yuge, Yoriko Watanabe, Saori Kosugi, Hiroshi Nishida, Yukiko Kimura, Yusuke Endo, Katsumi Higaki, Eiji Nanba, Yoko Nishimura, Akiko Tamasaki, Masami Togawa, Yoshiaki Saito, Yoshihiro Maegaki, Kousaku Ohno, Yoshiyuki Suzuki
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY 3(3)
2016-03
DOI:
10.1002/acn3.292
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Development of a High-Sensitivity Quantitation Method for Arginine Vasopressin by High-Performance Liquid Chromatography Tandem Mass Spectrometry, and Comparison with Quantitative Values by Radioimmunoassay
Yasuko Tsukazaki, Naoto Senda, Kinya Kubo, Shigeru Yamada, Hiroyuki Kugoh, Yasuhiro Kazuki, Mitsuo Oshimura
ANALYTICAL SCIENCES 32(2)
2016-02
DOI:
10.2116/analsci.32.153
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Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model
Yasuhiro Kazuki, Masaharu Akita, Kaoru Kobayashi, Mitsuhiko Osaki, Daisuke Satoh, Ryo Ohta, Satoshi Abe, Shoko Takehara, Kanako Kazuki, Hiroshi Yamazaki, Tetsuya Kamataki, Mitsuo Oshimura
SCIENTIFIC REPORTS 6
2016-02
DOI:
10.1038/srep21419
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Dynamics of epigenetic regulation at the single-cell level
Lacramioara Bintu, John Yong, Yaron E. Antebi, Kayla McCue, Yasuhiro Kazuki, Narumi Uno, Mitsuo Oshimura, Michael B. Elowitz
SCIENCE 351(6274)
2016-02
DOI:
10.1126/science.aab2956
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Regulation of functional KCNQ1OT1 lncRNA by beta-catenin
Naohiro Sunamura, Takahito Ohira, Miki Kataoka, Daigo Inaoka, Hideyuki Tanabe, Yuji Nakayama, Mitsuo Oshimura, Hiroyuki Kugoh
SCIENTIFIC REPORTS 6
2016-02
DOI:
10.1038/srep20690
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Regulation of functional KCNQ1OT1 lncRNA by beta-catenin
Naohiro Sunamura, Takahito Ohira, Miki Kataoka, Daigo Inaoka, Hideyuki Tanabe, Yuji Nakayama, Mitsuo Oshimura, Hiroyuki Kugoh
SCIENTIFIC REPORTS 6
2016-02
DOI:
10.1038/srep20690
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Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions
Masataka Ida, Mizuho Ando, Masayuki Adachi, Asumi Tanaka, Kodai Machida, Kunihiro Hongo, Tomohiro Mizobata, Miho Yoshida Yamakawa, Yasuhiro Watanabe, Kenji Nakashima, Yasushi Kawata
JOURNAL OF BIOCHEMISTRY 159(2)
2016-02
DOI:
10.1093/jb/mvv091
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Diapause is associated with a change in the polarity of secretion of insulin-like peptides
Yohei Matsunaga, Yoko Honda, Shuji Honda, Takashi Iwasaki, Hiroshi Qadota, Guy M. Benian, Tsuyoshi Kawano
NATURE COMMUNICATIONS 7
2016-02
DOI:
10.1038/ncomms10573
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Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans
Naoyuki Nakada, Akio Kawamura, Hidetaka Kamimura, Koya Sato, Yasuhiro Kazuki, Masakazu Kakuni, Masato Ohbuchi, Kota Kato, Chise Tateno, Mitsuo Oshimura, Takashi Usui
BIOPHARMACEUTICS & DRUG DISPOSITION 37(1)
2016-01
DOI:
10.1002/bdd.1990
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Potential usage of human artifi cial chromosome for regenerative medicine
Narumi Uno, Yasuhiro Kazuki, Mitsuo Oshimura
Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects
2016-01-01
DOI:
10.1007/978-4-431-55666-4_7
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Studies of Tumor Suppressor Genes via Chromosome Engineering
Hiroyuki Kugoh, Takahito Ohira, Mitsuo Oshimura
CANCERS 8(1)
2016-01
DOI:
10.3390/cancers8010004
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Anthocyanin suppresses the toxicity of A beta deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease
Miho Yoshida Yamakawa, Kazuyuki Uchino, Yasuhiro Watanabe, Tadashi Adachi, Mami Nakanishi, Hikari Ichino, Kunihiro Hongo, Tomohiro Mizobata, Saori Kobayashi, Kenji Nakashima, Yasushi Kawata
NUTRITIONAL NEUROSCIENCE 19(1)
2016-01
DOI:
10.1179/1476830515Y.0000000042
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Crystal structure of D-stereospecific amidohydrolase from Streptomyces sp 82F2-insight into the structural factors for substrate specificity
Jiro Arima, Kana Shimone, Kazusa Miyatani, Yuka Tsunehara, Yoshitaka Isoda, Tomoya Hino, Shingo Nagano
FEBS JOURNAL 283(2)
2016-01
DOI:
10.1111/febs.13579
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Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts
C. D. Navo, F. Corzana, E. M. Sanchez-Fernandez, J. H. Busto, A. Avenoza, M. M. Zurbano, E. Nanba, K. Higaki, C. Ortiz Mellet, J. M. Garcia Fernandez, J. M. Peregrina
ORGANIC & BIOMOLECULAR CHEMISTRY 14(4)
2016
DOI:
10.1039/c5ob02281a
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Haploidization via Chromosome Elimination: Means and Mechanisms
Takayoshi Ishii, Raheleh Karimi-Ashtiyani, Andreas Houben
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 67 67
2016
DOI:
10.1146/annurev-arplant-043014-114714
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Generation of haploid plants. (Industrieanmeldung), Veröffentlichung: 03.03.2016, IPK-Nr. 2014/01, EP 14182719.6
Houben, A, Karimi Ashtiyani, R., Ishii, T, Stein, N, Kumlehn, J
2016
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Radiolabeled liposome imaging determines an indication for liposomal anticancer agent in ovarian cancer mouse xenograft models.
Ken Ito, Shusei Hamamichi, Makoto Asano, Yusaku Hori, Junji Matsui, Masao Iwata, Yasuhiro Funahashi, Izumi O Umeda, Hirofumi Fujii
Cancer science 107(1)
2016-01
DOI:
10.1111/cas.12841
