507. Kazuki Y., Hoshiya H., Takiguchi M., Abe s., Iida Y., Osaki M., Katoh M., Hiratsuka M., Shirayoshi Y., Hiramatsu K., Ueno E., Kajitani N., Yoshino T., Kazuki K., Ishihara C., Takehara S., Tsuji S., Ejima F., Toyoda A., Sakaki Y., Larionov V., Kouprina N., Oshimura M.: Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Therapy, 18:384-93, 2011
508. Li Y., Matsumori H., Nakayama Y., Osaki M., Kojima H., Kurimasa A., Ito H., Mori S., Katoh M., Oshimura M., Inoue T.: SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis. Genes Cells, 16:34-45. 2011
509. Qi DL., Ohhira T., Fujisaki C., Inoue T., Ohta T., Osaki M., Ohshiro E., Seko T., Aoki S., Oshimura M., Kugoh H.: Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. 31:1624-36, Mol Cell Biol., 2011
510. Yamaguchi S, Kazuki Y, Nakayama Y, Nanba E, Oshimura M, Ohbayashi T.: A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector. Plos One, 6e17267, 2011
511. Osaki M., Takeshita F., Sugimoto Y., Kosaka N., Yamamoto Y., Yoshioka Y., Kobayashi E., Yamada T., Kawai A., Inoue T., Ito H., Oshimura M., Ochiya T.: MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression. Mol Ther., 19:1123-30, 2011
512. Osaki M., Inaba A., Nishikawa K., Sugimoto Y., Shomori K., Inoue T., Oshimura M., Ito H.: Cysteine-rich protein 61 suppresses cell invasion via down-regulation of matrix metalloproteinase-7 expression in the human gastric carcinoma cell line MKN-45. Mol Med Report, 3:711-5, 2011
513. Wang CC., Kazuki Y., Oshimura M., Ikeo K., Gojobori T.: Gene dosage imbalance of human chromosome 21 in mouse embryonic stem cells differentiating to neurons. Gene, 481:93-101, 2011
514. Meguro-Horike M., Yasui DH., Powell W., Schroeder DI., Oshimura M., Lasalle JM., Horike S.: Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. Hum Mol Genet., 20:3798-810, 2011
515. Kazuki Y. and Oshimura M.: Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models. Mol Ther., 19:1591-601, 2011
516. Kurosaki H., Hiratsuka M., Imaoka N., Iida Y., Uno N., Kazuki Y., Ishihara C., Yakura Y., Mimuro J., Sakata Y., Takeya H., Oshimura M.:Integration-free and stable expression of FVIII using a human artificial chromosome. Journal of Human Genetics, 56:727-33, 2011
517. Tedesco FS., Hoshiya H., D’Antona G., Gerli M. FM., Messina G., Antonini S., Tonlorenzi R., Benedetti S., Berghella L., Torrente Y., Kazuki H., Bottinelli R., Oshimura M., Cossu G.,: Stem Cell-Mediated transfer of a Human Artificial Chromosome ameliorates muscular Dystrophy. Science TM., 3:96ra78., 2011
518. 香月康宏、押村光雄：ヒト染色体導入ヒト型マウス/生物機能モデルと新しいリソース・リサーチツール (株)エル・アイ・シー、p432-435, 2011
519. 香月康宏、押村光雄：iPS細胞とヒト人工染色体ベクターを用いた新たな筋ジストロフィー遺伝子治療に向けて, Medical Science Digest, 2011
520. 香月康宏、押村光雄：染色体工学技術による医薬品開発のためのヒト化モデル動物の開発, 毒性質問箱 2011
521. 香月康宏、押村光雄：ヒト人工染色体ベクターによる遺伝子細胞治療へ向けて, 日本臨床 2011.
522. Yasunaga M., Oumi N., Osaki M., Kazuki Y., Nakanishi T., Oshimura M., Sato K.: Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas. PLoS One, 6:e24956, 2011
523. Nawata H., Kashino G., Tano K., Daino K., Shimada Y., Kugoh H., Oshimura M., Watanabe M.: Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. Plos One, 6:e25319, 2011
524. Hiratsuka M., Uno N., Ueda K., Kurosaki H., Imaoka N., Kazuki K., Ueno E., Akakura Y., Katoh M., Osaki M., Kazuki Y., Nakagawa M., Yamanaka S., Oshimura M.: Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors. PLoS One, 2011
525. Kim JH, Kononenko A, Erliandri I, Kim TA, Nakano M, Iida Y, Barrett JC, Oshimura M, Masumoto H, Earnshaw WC, Larionov V, Kouprina N.:
Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci U S A. 108:20048-53, 2011
526. Kakeda M., Nagata K., Osawa K., Matsuno H., Hiratsuka M., Sano A., Okazaki A., Shitara S., Nishikawa S., Masuya A., Hata T., Wako S., Osaki M., Kazuki Y., Oshimura M., Tomizuka K.: A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells. Biochem Biophys Res Commun., 415:439-44.2011
527. Kazuki Y., Oshimura M.：Toward gene and cell therapy using human artificial chromosome Nihon Rinsho, 69:2142-7. 2011
528. Itoh M., Tahimic CG, Ide S, Otsuki A, Sasaoka T, Noguchi S, Oshimura M, Goto YI, Kurimasa A.：Methyl CpG-binding Protein Isoform MeCP2_e2 Is Dispensable for Rett Syndrome Phenotypes but Essential for Embryo Viability and Placenta Development. J Biol Chem., 287:13859-67,2012
529. Takehashi M., Tada M., Kanatsu-Shinohara M., Morimoto H., Kazuki Y., Oshimura M., Tada T., Shinohara T.: Hybridization of Testis-Derived Stem Cells with Somatic Cells and Embryonic Stem Cells in Mice. Biol Reprod., 86:178, 2012
530. 香月康宏、押村光雄：iPS細胞を用いた遺伝子・細胞治療への挑戦, 実験医学 Vol.30 No.10(増刊)、p180-187, 2012
531. 香月康宏、押村光雄：遺伝子導入のための新規ヒト人工染色体ベクター、細胞工学 Vol.31 No.11, p1260-1267, 2012
532. Nakanishi T., Kokubun K., Oda H., Aoki M., Soma A., Taniguchi M., Kazuki Y., Oshimura M., Sato K.: Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice. Bone. 51:369-375, 2012
533. Imaoka N., Hiratsuka M., Osaki M., Kamitani H., Kambe A., Fukuoka J., Kurimoto M., Nagai S., Okada F., Watanabe T., Ohama E., Kato S., Oshimura M.: Prognostic significance of sirtuin 2 protein nuclear localization in glioma: An immunohistochemical study. Oncol Rep., 28:923-930, 2012
534. Tedesco FS., Gerli MF., Perani L., Benedetti S., Ungaro F., Cassano M., Antonini S., Tagliafico E., Artusi V., Longa E., Tonlorenzi R., Ragazzi M., Calderazzi G., Hoshiya H., Cappellari O., Mora M., Schoser B., Schneiderat P., Oshimura M., Bottinelli R., Sampaolesi M., Torrente Y., Broccoli V., Cossu G.: Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy. Sci Transl Med., 4:140ra89, 2012
535. Watanabe Y., Kazuki Y., Oshimura M., Ikemura T., Maekawa M.: Replication timing in a single human chromosome 11 transferred into the Chinese hamster ovary (CHO) cell line. Gene, 510:1-6, 2012
536. Oshimura M., Kazuki Y., Uno N.: Challenge toward gene-therapy using iPS cells for Duchenne muscular dystrophy. Rinsho Shinkeigaku. 52:1139-1142, 2012
537. Kouprina N., Samoshkin A., Erliandri I., Nakano M., Lee HS., Fu H., Iida Y., Aladjem M., Oshimura M., Masumoto H., Earnshaw WC., Larionov V.: Organization of Synthetic Alphoid DNA Array in Human Artificial Chromosome (HAC) with a Conditional Centromere. ACS Synth Biol. 1:590-601, 2012
538. Takiguchi M., Kazuki Y., Hiramatsu K., Abe S., Iida Y., Takehara S., Nishida T., Ohbayashi T., Wakayama T., Oshimura M.: A Novel and Stable Mouse Artificial Chromosome Vector. ACS Synth Biol. 2012
539. Kazuki Y., Kobayashi K., Aueviriyavit S., Oshima T., Kuroiwa Y., Tsukazaki Y., Senda N., Kawakami H., Ohtsuki S., Abe S., Takiguchi M., Hoshiya H., Kajitani N., Takehara S., Kubo K., Terasaki T., Chiba K., Tomizuka K., Oshimura M.: Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Hum Mol Genet., 22(3):578-92, 2013
540. Yakura Y., Ishihara C., Kurosaki H., Kazuki Y., Komatsu N., Okada Y., Doi T., Takeya H., Oshimura M.: An induced pluripotent stem cell-mediated and integration-free factor VIII expression system. Biochem Biophys Res Commun. 431:336-41, 2013
541. Uno N., Uno K., Zatti S., Ueda K., Hiratsuka M., Katoh M., Oshimura M.: The transfer of human artificial chromosomes via cryopreserved microcells. Cytotechnology. 65(5):803-92,013
542. Hashimoto M., Kobayashi K., Watanabe M., Kazuki Y., Takehara S., Inaba A., Nitta SI., Senda N., Oshimura M., Chiba K.: Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver. J Lipid Res. 2013
543. 押村光雄：出会いと融合から生まれる新展開、 細胞工学、Vol.32, No.5, p518-519,2013
544. Miyake K., Yang C., Minakuchi Y., Ohori K., Soutome M., Hirasawa T., Kazuki Y., Adachi N., Suzuki S., Itoh M., Goto YI., Andoh T., Kurosawa H., Oshimura M., Sasaki M., Toyoda A., Kubota T.: Comparison of Genomic and Epigenomic Expression in Monozygotic Twins Discordant for Rett Syndrome. PLoS One 8:e66729,2013
545. Osaki M., Chinen H., Yoshida Y., Ohhira T., Sunamura N., Yamamoto O., Ito H., Oshimura M., Kugoh H.: Decreased PITX1 gene expression in human cutaneous malignant melanoma and its clinicopathological significance. Eur J Dermatol. 23:344-349, 2013
546. Kazuki K, Takehara S, Uno N, Imaoka N, Abe S, Takiguchi M, Hiramatsu K, Oshimura M, Kazuki Y.: Highly stable maintenance of a mouse artificial chromosome in human cells and mice. Biochem Biophys Res Commun. 442:44-50, 2013
547. Takehara S, Schulz TC, Abe S, Takiguchi M, Kazuki K, Kishigami S, Wakayama T, Tomizuka K, Oshimura M, Kazuki Y.: A novel transchromosomic system: stable maintenance of an engineered Mb-sized human genomic fragment translocated to a mouse chromosome terminal region. Transgenenic Res., 2014
548. Nakabayashi M, Osaki M, Kodani I, Okada F, Ryoke K, Oshimura M, Ito H, Kugoh H.: PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia. Oncol Lett. 7:750-754. 2014
549. Wakai M, Abe S, Kazuki Y, Oshimura M, Ishikawa F.: A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells. PLoS One. 2014 Feb 18;9(2):e88530.
550. Watanabe M, Kurai J, Tomita K, Sano H, Abe S, Saito R, Minato S, Igishi T, Burioka N, Sako T, Yasuda K, Mikami M, Kurita S, Tokuyasu H, Ueda Y, Konishi T, Yamasaki A, Aiba S, Oshimura M, Shimizu E.: Effects on asthma and induction of interleukin-8 caused by Asian dust particles collected in western Japan. J Asthma. 2014
551. 宇野愛海、香月康宏、押村光雄：ヒト人工染色体を用いた遺伝子・再生医療へ向けて、再生医療 vol.12 No.4, 2013
552. 香月康宏、押村光雄：染色体工学とゲノム編集の融合による医学・薬学研究への応用、実験医学別冊 今すぐ始めるゲノム編集 2014
553. Inoue T., Nakayama Y., Li Y., Matsumori H., Takahashi H., Kojima H., Wanibuchi H., Katoh M., Oshimura M.: SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors. FEBS J. 281(11):2623-37, 2014
554. Iida Y., Kazuki Y., Hayashi M., Ueda Y., Hasegawa M., Kouprina N., Larionov V., Oshimura M.:Bi-HAC vector system towards gene and cell therapy. ACS Synthetic Biology, 3(2):83-90, 2014
555. Tsuji S., Kawamura F, Kubiura M., Hayashi A., Ohbayashi T., Kazuki ., Chesné C., Oshimura M., Tada M.:Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells. PloS One 9(8):e104123, 2014.
556. Kazuki Y., Yakura Y., Abe S., Osaki M., Kajitani N., Kazuki K., Takehara S., Honma K., Suemori H., Yamazaki S., Sakuma T., Toki T., Shimizu R., Nakauchi H., Yamamoto T., Oshimura M.: Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies. Sci Rep. 4:6136, 2014
557. Suzuki T., Kazuki Y., Oshimura M., Hara T.:A Novel System for Simultaneous or Sequential Integration of Multiple Gene-Loading Vectors into a Defined Site of a Human Artificial Chromosome. PLoS One.9(10): e11040, 2014
558. Shimamoto A., Kagawa H., Zensho K., Sera Y., Kazuki Y., Osaki M., Oshimura M., Ishigaki Y., Hamasaki K., Kodama Y., Yuasa S., Fukuda K., Hirashima K., Seimiya H., Koyama H., Shimizu T., Takemoto M., Yokote K., Goto M., Tahara H. :Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture PLoS One. 2014; 9(11): e112900.
559. Suematsu T., Li Y., Kojima H., Nakajima K., Oshimura M., Inoue T.:Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition. Biochem Biophys Res Commun. 453(3):588-94, 2014
560. Yasunaga M., Murotomi K., Abe H., Yamazaki T., Nishii S., Ohbayashi T., Oshimura M., Noguchi T., Niwa K., Ohmiya Y., Nakajima Y.: Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3.J Biotechnol. 20;194:115-23, 2015
561. Ohira T., Naohiro S., Nakayama Y., Osaki M., Okada F., Oshimura M., Kugoh H.: miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells. Sci Rep. 5:8201, 2015
562. Oshimura M., Uno N., Kazuki Y., Katoh M., Inoue T.:A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges. Chromosome Res. 23(1):111-33, 2015
563. Nakayama Y., Uno N., Uno K., Mizoguchi Y., Komoto S., Kazuki Y., Nanba E., Inoue T., Oshimura M.: Recurrent micronucleation through cell cycle progression in the presence of microtubule inhibitors. Cell Struct Funct. 40(1):51-9, 2015
564. Kato K., Ohbuchi M., Hamamura S., Ohshita H., Kazuki Y., Oshimura M., Sato K., Nakada N., Kawamura A., Usui T., Kamimura H., Tateno C.: Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver.Drug Metab Dispos. 43(8):1208-17, 2015
565. Yoshimura Y., Nakamura K., Endo T., Kajitani N., Kazuki K., Kazuki Y., Kugoh H., Oshimura M., Ohbayashi T.: Mouse embryonic stem cells with a multi-integrase mouse artificial chromosome for transchromosomic mouse generation. Transgenic Res. 2015 Aug;24(4):717-27
566. Watanabe M., Noma H., Kurai J., Sano H., Saito R., Abe S., Kimura Y., Aiba S., Oshimura M., Yamasaki A., Shimizu E.: Decreased pulmonary function in school children in Western Japan after exposures to Asian desert dusts and its association with interleukin-8. Biomed Res Int. vol.2015:583293, 2015
567. Hiratsuka M., Ueda K., Uno N., Uno K., Fukuhara S., Kurosaki H., Takehara S., Osaki M., Kazuki Y., Kurosawa Y., Nakamura T., Katoh M., Oshimura M.: Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome. BMC Biotechnol. 15:58, 2015
568. Narai T., Katoh M., Inoue T., Taniguchi M., Kazuki K., Kazuki Y., Sato K., Kodani I., Ryoke K., Oshimura M.: Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector. Yonago Acta Med. 58(1):23-9, 2015
569. Nakada N., Kawamura A., Kamimura H., Sato K., Kazuki Y., Kakuni M., Ohbuchi M., Kato K., Tateno C., Oshimura M., Usui T.: Murine Cyp3a knockout chimeric mice with humanized liver:prediction of the metabolic profile of nefazodone in humans. Biopharm Drug Dispos. 2015
570. Watanabe M., Kurai J., Minato S., Noma H., Sano H., Saito R., Aiba S., Oshimura M., Hatakeyama K., Yamasaki A., Shimizu E.: Difference in interleukin-8 transcriptional activity induced in THP-G8 cells by particulate matter collected in winter and summer in western Japan. J Med Invest. 62(3-4):145-148, 2015
572. Nishio S., Ohira T., Sunamura N., Oshimura M., Ryoke K., Kugoh H.: Repression of hTERT transcription by the introduction of chromosome 3 into human oral squamous cell carcinoma. Biochem Biophys Res Commun. pii: S0006-291X(15)30636-7, 2015
571. 香月康宏、押村光雄「進化するゲノム編集技術」（株）NTS
第1編-第1章「第5節 人工染色体技術とゲノム編集技術の融合による遺伝子改変技術」p.49-58
572. Watanabe Y., Kazuki Y., Kazuki K., Ebiki M., Nakanishi M., Nakamura K., Yoshida Yamakawa M., Hosokawa H., Ohbayashi T., Oshimura M., Nakashima K.: Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis. Mol Ther Nucleic Acids. 4:e253, 2015 \
573. Watanabe M., Noma H., Kurai J., Sano H., Kitano H., Saito R., Kimura Y., Aiba S., Oshimura M., Shimizu E.: Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8. Int J Environ Res Public Health. 12(11):14229-43., 2015
574. Uno N., Uno K., Komoto S., Suzuki T., Hiratsuka M., Osaki M., Kazuki .Y, Oshimura M.: Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy. Mol Ther Nucleic Acids. 4:e272., 2015
575. Kugoh H., Ohira T., Oshimura M.: Studies of Tumor Suppressor Genes via Chromosome Engineering. Cancers. 8(1)4, 2016
576. Tsukazaki Y., Senda N., Kubo K., Yamada S., Kugoh H., Kazuki Y., Oshimura M.: Development of a High-Sensitivity Quantitation Method for Arginine Vasopressin by High-Performance Liquid Chromatography Tandem Mass Spectrometry, and Comparison with Quantitative Values by Radioimmunoassay. Anal Sci. 32(2):153-9, 2016
577. Sunamura N., Ohira T., Kataoka M., Inaoka D., Tanabe H., Nakayama Y., Oshimura M., Kugoh H.: Regulation of functional KCNQ1OT1 lncRNA by β-catenin. Sci Rep. 6:20690, 2016
578. Kazuki Y., Akita M., Kobayashi K., Osaki M., Satoh D., Ohta R., Abe S., Takehara S., Kazuki K., Yamazaki H., Kamataki T., Oshimura M.: Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model. Sci Rep. 6:21419, 2016
579. Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB.: Dynamics of epigenetic regulation at the single-cell level. Science. 351(6274):720-4, 2016