婦人科腫瘍学研究室

佐藤慎也、 小松宏彰、
澤田真由美、飯田祐基、大川雅世、
曳野耕平、 山本康嗣、平塚 由貴
目次

婦人科腫瘍研究

婦人科がんに対するより有効な診断方法や新規治療法の開発を目指したトランスレーショナルリサーチ(基礎と臨床の橋渡し研究)を主に行っています。

また、多施設との共同研究や臨床試験にも積極的に参加しています。

基礎的研究

現在進行中および今後開始予定の研究テーマ

技術面で染色体工学研究センターと共同で、以下のようなテーマで研究を行っています。

鳥取大学染色体工学研究センター

  1. 可逆的不死化細胞株の樹立による卵巣癌新規診断マーカーおよび治療薬の開発の試み
    （Komatsu H*, et al. Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation. Human cell. 2024）
    卵巣癌の発生機序は、組織学的、臨床病理学的背景の観点から明らかにされつつりますが、一方で分子レベルでの解析はいまだ不明な点が多いとされます。その最も大きな理由の一つとして正常卵巣上皮や良性病変および境界悪性病変由来の細胞株が存在しないため、悪性化に至る機序を詳細に解析できないことがあげられます。
    独自の新規不死化法により、増殖能の乏しい上記各細胞の不死化細胞株を樹立し、それらの特徴を遺伝子発現レベルで明らかにすることで、従来は不可能であった卵巣における発癌過程における遺伝子発現レベルの変化をin vitroおよびin vivoレベルで詳細に解析することが可能となり、卵巣癌の早期診断マーカーの単離、さらには卵巣癌の効果的な治療への展開を行っていきます。
  2. 子宮内膜症に関する癌化を解明する試み
    （Okawa M, Komatsu H*, et al. Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor–stroma interactions and carcinogenesis. Human Cell. 2025 ）
    子宮内膜細胞の細胞株樹立を行ったうえで、子宮内膜細胞、卵巣上皮細胞、内膜症性嚢胞細胞、卵巣明細胞癌細胞の各々の特徴を遺伝子発現から明らかにし、さらに患者の血液(血球)を用いて細胞株とのプロファイリングが一致するかを確認します。これにより、正常⇒内膜症性嚢胞⇒明細胞癌の癌シークエンスあるいは、子宮内膜と卵巣上皮との関連を探索します。その結果から、内膜症と前述の各種癌との関連、早期診断マーカーの単離と治療応用を目指します。
  3. 子宮体癌シークエンスの炎症理論の構築への試み
    子宮内膜細胞の不死化細胞株を用いて、ヒト化抗体産生マウスに内膜細胞を埋め込み、モデルマウスを作成し、生着した内膜部分に炎症を惹起させ、異物を挿入して子宮内膜が癌化するかの確認を行います。癌化した場合は、ドライバー遺伝子を探索するために癌化した細胞を株化し、遺伝子の網羅的解析を行います。
  4. 卵巣癌における新規予後バイオマーカーの同定と臨床応用への展開
    （Hikino K, Komatsu H, et al. Matrix Metalloproteinase-1 Expression as an Independent Prognostic Biomarker in Epithelial Ovarian Carcinoma. Anticancer Research. 2025）
    卵巣癌は依然として予後不良な婦人科悪性腫瘍の一つであり、その治療成績向上のためには、予後予測および治療層別化に資する信頼性の高いバイオマーカーの開発が求められています。特に、腫瘍の浸潤・転移機構に関与する分子の解明は、臨床的意義が高いと考えられます。
    本研究では、細胞外マトリックス分解に関与する酵素群であるマトリックスメタロプロテアーゼの一つであるMMP-1に着目し、上皮性卵巣癌における発現と臨床病理学的因子との関連、および予後への影響を検討しました。免疫組織学的解析および臨床データを統合的に評価した結果、MMP-1高発現は独立した予後不良因子であることが明らかとなり、腫瘍の進展や転移能と密接に関連する可能性が示唆されました。
    これらの知見は、MMP-1が卵巣癌における新規予後バイオマーカーとして有用であるだけでなく、将来的には分子標的治療の候補となり得る可能性を示すものです。さらに、血中マーカーやリキッドバイオプシーへの応用を視野に入れることで、低侵襲な診断および治療戦略の構築にも寄与することが期待されます。
    本研究成果を基盤として、婦人科癌における転移・浸潤機構のさらなる解明とともに、個別化医療の実現に向けた新規診断・治療法の開発を推進していきます。

過去の研究テーマ

  • 卵巣粘液性がんの細胞生物学的特性の解明と抗がん剤耐性克服の試み
  • 耐性遺伝子を用いた上皮性卵巣がん抗がん剤感受性試験の試み
  • 卵巣明細胞腺がんにおける 分子標的治療薬の至適併用療法選択と感受性予測マーカー探索
  • 上皮性卵巣がんにおけるバイオマーカーとしての血管新生因子発現の探索
  • 子宮頸がんにおける血管新生因子の予後バイオマーカーとしての意義の検討
  • 卵巣明細胞癌および高異型度漿液性癌におけるエストロゲン受容体サブタイプ発現の検討
  • 婦人科癌における転移・遊走因子の探索

臨床的研究

  1. ロボット支援下子宮筋腫核出術
    　令和10年度の診療報酬改定を目指して、子宮筋腫に対するロボット支援子宮筋腫核出術を行っております。開腹手術や腹腔鏡手術と比較して、精緻な操作で子宮へのダメージ軽減や術後のQOL向上が可能となります。
  2. 制吐療法の有効性および安全性に関する検討
  3. 糖尿病を有する婦人科癌患者の血糖値の推移
  4. 創部閉鎖のベストプラクティス
  5. 神経温存術式の導入と神経因性膀胱
  6. 多施設共同臨床試験への参加

JCOG(日本臨床腫瘍研究グループ)、JGOG(婦人科悪性腫瘍研究機構)などの全国規模の臨床試験、SGSG(三海婦人科がんスタディグループ)などの地方グループによる臨床試験に参加しています。

業績

目次

2025年

Kawai Y, Kuwahara K, Minoura A, Shimada Y, Kondo M, Fukushima H, Komatsu H, Sugiyama T.
Gender disparities in the association between marital status and intention to leave research careers among medical researchers.
Environmental Health and Preventive Medicine. 2026. In Press.
Suemitsu T, Nagayasu Y, Shinagawa M, Komatsu H*, Maki J, Hirose Y, Fto E, Isobe M, Masuyama H, Watari H.
Nationwide Faculty Development Seminars in Obstetrics and Gynecology in Japan: Evaluating Practical Initiatives and Educational Outcomes.
J Obstet Gynaecol Res. 2026.2026 Feb;52(2):e70214.
Komatsu H*, Sunada M, Baba T, Terai Y, Yokoyama Y, Mandai M, Kobayashi H. Equivalent Certificate Training Program for Gynecologic Robotic Surgery: A Multicenter Feasibility Study.
Asian Journal of Endoscopic Surgery. 2026 Jan-Dec;19(1):e70266.
Komatsu H*, Wada I, Yamamoto K, Hiratsuka Y, Hikino K, Okawa M, Iida Y, Nagata H, Sawada M, Sato S, Taniguchi F. Implementation of the Hugo™ Robotic System: Early Outcomes and Learning Curves in Hysterectomy by Surgeons With and Without Prior Robotic Experience.
Asian Journal of Endoscopic Surgery. 2026 Jan-Dec;19(1):e70247.
Shikama A, Nishio H, Okugawa K, Kajiyama H, Suzuki N, Fujiwara H,
Watari H, Komatsu H, Yamagami W, Satoh T, Kawana K.
Current Status of Fertility-Sparing Treatment for Gynecological Cancers in Japan: A Nationwide Survey.
J Obstet Gynaecol Res. 2026 Feb;52(2):e70187.
Okawa M, Komatsu H*, Kazuki Y, Kazuki K, Hichiwa G, Hikino K, Iida Y, Sawada M, Kugoh H, Sato S, Oshimura M, Harada T, Taniguchi F.
Establishment of immortalized ovarian stromal cell lines using Sendai virus vectors: a platform for studying tumor–stroma interactions and carcinogenesis.
Human Cell. 2025. In Press.
Azuma Y, Fujioka R, Yamamoto K, Matsumoto M, Nagata H, Wada I, Moriyama M, Komatsu H, Taniguchi F.
Prediction of Periureteral Adhesions by Drop Infusion Pyelography Before Laparoscopic Hysterectomy: A Retrospective Study.
J Obstet Gynaecol Res. 2025 Nov;51(11):e70141.
Komatsu H*, Hiratsuka Y, Yamamoto K, Hikino K, Okawa M, Iida Y, Nagata H, Ikebuchi A, Sawada M, Sato S, Taniguchi F.
Advances and Challenges in Robotic-Assisted Gynecologic Surgery: A Comprehensive Review of Port Strategies, Surgical Platforms, and Learning Curves in Japan.
J Obstet Gynaecol Res. 2025 Oct;51(10):e70089.
Miyamoto K, Komatsu H*, Yamamoto K, Nagata H, Nagira K, Harada T, Taniguchi F.
Risk factors for venous thromboembolism in pregnant women in Japan: A retrospective study.
J Matern Fetal Neonatal Med. 2025 Dec;38(1):2551645.
Sugita Y, Komatsu H*, Kodera C, Urushiyama D, Enomoto N, Nagasaki S,
Odai T, Suemitsu T, Onodera Y, Hosokawa Y, Ogawa R.
Impact of Abnormal Cesarean Section Scar Formation on Quality of Life and Postpartum Depression: A Cross-sectional Study in Japan.
Int J Gynecol Obstet. 2025 Aug 14.
Hikino K, Komatsu H*, Kazuki Y, Kazuki K, Yamamoto K, OkawaM, IidaY, Sawada M, Hichiwa G, Sato S, Kugoh H, Oshimura M, Harada T, Taniguchi F
Matrix Metalloproteinase-1 Expression as an Independent Prognostic Biomarker in Epithelial Ovarian Carcinoma.
Anticancer Research. 2025 Oct;45(10):4473-4481.
Nagata H, Komatsu H*, Yamamoto K, Okawa M, Hikino K, Iida Y, Wada I, Sawada M, Sato S, Taniguchi F.
Comparison of Hysterectomy Using Four Different Robotic Surgical Systems; a retrospective cohort study.
Japanese Journal of Clinical Oncology. 2025 Oct;55(10): 1112–1116.
Komatsu H*, Ueki M, Yamada N, Taniguchi F, Harada T.
Implementation and educational impact of the step ladder system: A structured clinical competency framework for obstetrics and gynecology.
Int J Gynecol Obstet. 2025 Dec;171(3):1378-1386.
Nishio H, Matsumoto K, Komatsu H, Morita M, Nagasawa T, Suzuki J, Nishio S, Ishikawa M, Satoh T.
Current status of carboplatin desensitization therapy for gynecologic malignancies.
J Gynecol Oncol. 2026 Jan;37(1):e11.
Kamijo K, Suemitsu T, Hayashi M, Iida Y, Ogawa A, Kashima Y, Komatsu H, Koga K, Taniguchi F.
Gender Differences in Factors Influencing Specialty Choice in Obstetrics and Gynecology: A National Survey of Graduating Senior Residents.
J. Obstet. Gynaecol. Res. 2025.
Hasegawa K, Nishio S, Yamamoto K, Kudoh A, et al.
Tegafur-uracil maintenance chemotherapy post-chemoradiotherapy for cervical cancer: Randomized trial.
European Journal of Cancer. 2025
Jyoti M, Dipanwita B, Se Ik K, Komatsu H, Shuk Tak K, Yen-Ling L, Chia-Sui W, Jie Y, Carolyn ZC, Kittipat C, Yoo-Young L, Joseph J. N.
Current status and challenges in training the next generation of gynecologic cancer care providers in Asia.
J Gynecol Oncol. 2025.
ida Y, Kato M, Komatsu H, Ishikawa T, Sato T.
Questionnaire-based survey on the extent of lymph node dissection during interval debulking surgery after neoadjuvant chemotherapy for patients with advanced ovarian cancer in the Gynecologic Cancer Study Group of JCOG.
Int J Clin Oncol. 2025. In Press.
Komatsu H*, Yamamoto K, Hikino K, Okawa M, Iida Y, Wada I, Sawada M, Sato S, Taniguchi F.
A Novel Port and Arm Placement Strategy for the Hugo™ Robotic-Assisted Surgery (RAS) System in Gynecologic Oncology: Initial Experience and Technical Considerations.
Asian Journal of Endoscopic Surgery. 2025. Jan-Dec;18(1):e70045.
Iida Y, Sato S, Yamamoto K, Okawa M, Hikino K, Sawada M, Komatsu H, Taniguchi F.
Potential Efficacy of Inflammatory Response Markers for the Detection of Ovarian Cancer in Patients with Endometrioma.
Yonago Acta Med. 2025 Jan 23;68(1):51-57.
Hayasaka M, Dofutsu, M, Yoshimura T, Taima A, Komatsu H*, Kobayashi H.
Current Status and Prospects of Robotic Surgery Adoption in Obstetrics and Gynecology: Insights from a Nationwide Survey.
J Robot Surg. 2025. Feb 12;19(1):67.
Mori K, Komatsu H, Shimizu M, Sakaguchi K, Koga K, Taniguchi F, Hiroshi S
What preferences do potential obstetrics-gynecology specialists have regarding their working environment? Results of a questionnaire survey of participants in the Summer School 2023 of the Japanese Society of Obstetrics and Gynecology.
J. Obstet. Gynaecol. Res. 2024. Oct;50(10):1952-1964.

2024年

Nagao S, Nishio S, Takehara K, Sato S, Satoh T, Shimada M, Yamaguchi S, Tanabe H, Takano M, Horie K, Takei Y, Imai Y, Hibino Y, Hasegawa K, Takekuma M, Nakamura K, Takano H, Fujiwara K, Masuyama H.
Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study.
Int J Clin Oncol. 2024 Oct;29(10):1594-1601.
Nagata H, Komatsu H*, Yamamoto K, Okawa M, Hikino K, Iida Y, Wada I, Ikebuchi A, Sawada M, Azuma Y, Sato S, Harada T, Taniguchi F
Comparison of Surgical Outcomes of da Vinci Surgical Systems X and Xi: A Single-center Study.
Asian J Endosc Surg. 2024 Jul;17(3):e13358.
Komatsu H*, Sawada M*, Iida Y, Wada I, Azuma Y, Kudoh A, Sato S, Harada T, Taniguchi F.
New surgery technique combining robotics and laparoscopy using the Hugo™ RAS system.
Asian J Endosc Surg. 2024 Jul;17(3):e13344.
IidaY, Osaki M*, Sato S, Izutsu R, Seong H, Komatsu H, Taniguchi F, Okada F.
AMIGO2 is involved in the spread of peritoneal metastasis in serous ovarian cancer via promoting adhesion to the peritoneal mesothelial cells.
Int J Clin Oncol. 2024 Sep;29(9):1354-1363.
Arai Y*, Yoshino G, Ohta K, Okanishi T, Kakee S, Mino Y, Komatsu H, Yamada N, Maegaki Y.
Impact of clinical clerkship integrated with clinical ladder on attending physicians’ self-efficacy.
BMC Medical Education. 2024 Apr 10;24(1):400.
Komatsu H*, Okawa M, Kazuki Y, Kazuki K, Hichiwa G, Shimoya K, Sato S, Taniguchi F, Oshimura M, Harada T
Characterization of immortalized ovarian epithelial cells with BRCA1/2 mutation. Human cell. 2024. Jul;37(4):986-996.
Ikebuchi A, Komatsu H*, Yamamoto K, Okawa M, Hikino K, Iida Y, Hosokawa M, Sawada M, Kudoh A, Sato S, Harada T, Taniguchi F
Outcome of robot-assisted surgery for stage IA endometrial cancer compared to open and laparoscopic surgeries: A retrospective study at a single institution.
J Robot Surg. 2024 Mar 23;18(1):133.
Komatsu H, Matsumoto K*, Morita M, Nagasawa T, Nishio H, Suzuki J,
Nishio S, Kobara H, Yunokawa M, Ariyoshi K, Hirayama T, Tokunaga H,
Ukita M, Yoriki K, Mori-Uchino M, Furusawa A, Togami S, Nakamura H, Ishikawa M, Satoh T.
A survey of carboplatin desensitization therapy in Japan: A multicenter retrospective study. Cancer Medicine. 2024. Mar;13(5):e6968.

2023年

Technical Certification System for Gynecological Robotic Surgery Task Force of the Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive TherapyIs There a Need for a Technical Certification System for Gynecological Robotic Surgery? Questionnaire Survey of Members of the Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy. Journal of Robotic Surgery. 2023.
Komatsu H, Hiraike O, Fukuhara R, Yokoyama Y*, Takahashi N, Nishi H, Baba T, Fujii T, Kitawaki J, Kobayashi H, Mandai M.
AMIGO2 expression as a predictor of recurrence in cervical cancer with intermediate risk.
Mol Clin Oncol. 2023 Jul; 19(1): 56.
Iida Y, Osaki M*, Shinya S, Izutsu R, Seong H, Okawa M, Osaku D, Komatsu H, Taniguchi F, Okada F.
Impact of myomectomy on the obstetric complications: a large cohort study in Japan.
Int J Gynecol Obstet. 2023;162: 977–982.
Komatsu H*, Fuminori Taniguchi, Tasuku Harada.
Perceptions and practice patterns of cancer survivorship care among Japanese gynecologic oncologists: The JGOG questionnaire survey.
J Gynecol Oncol. 2023 Jan;34(1):e10. doi: 10.3802/jgo.2023.34.e10. Epub 2022 Oct 26.
Asai-Sato M, Suzuki N, Sakai H, Itani Y, Sato S, Futagami M, Yoshida Y.
Impact of adenomyosis on perinatal outcomes: A large cohort study (JSOG database).
BMC Pregnancy and Childbirth. 2023 Aug 11;23(1):579. doi: 10.1186/s12884-023-05895-w.
Komatsu H*, Taniguchi F, Harada T.
The Learning Curve of Introduced Robotic-Assisted Hysterectomy vs Skilled Laparoscopic Hysterectomy for Benign Gynecologic Diseases.
J Obstet Gynaecol Res. 2023. Online ahead of print.
Iida Y, Komatsu H*, Kudoh A, Azuma Y, Sato S, Harada T, Taniguchi F.
Clinical characteristics and prognostic factors of endometrial stromal sarcoma and undifferentiated uterine sarcoma confirmed by central pathologic review: A multi-institutional retrospective study from the Japanese Clinical Oncology Group.
Gynecol Oncol. 2023 Sep;176:82-89.
Kikuchi A, Yoshida H, Tsuda H, Nishio S, Suzuki S, Takehara K, Kino N, Sumi T, Kato K, Yokoyama M, Nakamura K, Takano M, Sato S, Kato H, Tamate M, Horie K, Kato T, Sakamoto A, Fukunaga M, Kaku T, Yoshida M, Yaegashi N, Satoh T.
Prolonged second stage of labor in delivery using epidural analgesia is a risk factor for postpartum urinary retention.
Miyamoto K, Komatsu H*, Nagata H, Nagira K, Motomura E, Shimizu N, Tanaka A
J. Obstet. Gynaecol. Res. 2023 In Press.
First Report of Robotic-assisted Total Hysterectomy Using the HugoTM RAS System.
Komatsu H*, Wada I, Taniguchi F, Harada T.
Updates in Surgery. 2023. In Press.
Impact of COVID-19 on Gynecological Cancer Incidence: A Large Cohort Study in Japan.
Komatsu H, Yuji Ikeda#, Kawana K*, Nagase S, Yoshino K,
Yamagami W, Tokunaga H, Kato K, Kimura T, Aoki D (#; equal contribution)
Int J Clin Oncol. 2023 Dec 6. doi: 10.1007/s10147-023-02431-w.
Evaluation of the characteristics of ovarian endometrioma in patients with endometriosis: efficacy of a low-dose estrogen/progestogen combination
Komatsu H*, Sunada H, Endo Y, Noma H, Taniguchi F, Harada T
Gynecol Obstet Invest. 2023 Nov 11. doi: 10.1159/000534666.
Malignant Pericardial Tamponade Secondary to Ovarian Clear Cell Carcinoma.
Sawada M, Oishi T*, Nonaka M, Hikino K, Ookawa M, Iida Y, Hosokawa M, Komatsu H, Kudoh A, Sato S, Taniguchi F.
Yonago Acta Med. 2023 Oct 27;66(4):459-462.

2022年

Maeda Y, Hasegawa A, Miyake R, Dofutsu M, Higuchi Y, Osaku D, Suemitsu T, Onodera Y, Shozu M, Miura K, Yoshida Y, Komatsu H*, Watari H.
Association of online activities with obstetrics and gynecology specialty choice: a nationwide online survey. Int J Med Educ. Sep 28;13:261-266. 2022
Komatsu H, Nakagawa S, Yamagami W*, Yamada H, Miyashita S, Yoshino K, Kawana K, Shibahara H, Hamatani T, Aoki D.
Impact of the COVID-19 pandemic on surgery for benign diseases in gynecology: A nationwide survey by the Japan Society of Obstetrics and Gynecology. J Obstet Gynaecol Res. 2022 Oct 26.
Iida Y, Sato S*, Okawa M, Hikino K, Komatsu H, Kudoh A, Chikumi J, Oishi T, Harada T, Taniguchi F.
Prognostic value of human papillomavirus genotyping before and after cervical conization for squamous intraepithelial lesion. Acta Cytol. 28;1-10. 2022
Nagata H, Komatsu H*, Nakaso T, Kudoh A, Azuma Y, Taniguchi F.
Robot-Assisted Total Hysterectomy of Extremely Unusual Pelvic Anatomy: A Case Report and Literature Review. Yonago Acta Medica. Oct 25;65(4):315-319. 2022
Iida Y, Sato S*, Okawa M, Hikino K, Komatsu H, Kudoh A, Chikumi J, Oishi T, Harada T, Taniguchi F
Prognostic value of human papillomavirus genotyping before and after cervical conization for squamous intraepithelial lesion. Acta Cytol. In Press. 2022
Komatsu H*,Okawa M,Hikino H,Iida Y,Osaku D,Kudoh A,Chikumi J,Sato S,Oishi T,Harada T
A simplified procedure of nerve-sparing radical hysterectomy. J. Obstet. Gynaecol. Res. 48(3):766-773, 2022
Miyamoto K, Komatsu H*, Okawa M, Iida Y, Osaku D, Azuma Y, Tsuneto T, Harada T, Taniguchi F, Harada T
D-dimer level significance for deep vein thrombosis screening in the third trimester: a retrospective study. BMC Pregnancy and Childbirth. 2:21, 2022.
Nogami Y, Makabe K, Komatsu H, Kawana K, Okamoto A, Mikami M, Katabuchi H
Impact of COVID-19 on cervival cancer screening in Japan: A survey of population-based screening in urban Japan by the Japan Society of Gynecologic Oncology. J. Obstet. Gynaecol. Res. 48(3):757-765, 2022
Komatsu H, Fuminori T, Tasuku H*
Endometriosis and Adenomyosis: Hormonal Therapy in Endometriosis and Adenomyosis: Oral Contraceptives. Capter40, Pages 525-529, 2022.
Hirakawa T,Yotsumoto F,Shirasu N,Koyoshima C,Urushiyama D,Yoshikawa K,Miyata K,Kurakazu M,Koga KA,Aoki M,Nabeshima K,Osuga Y, Komatsu H,Taniguchi F,Harada T,Yasunaga S,Koga K,Miyamoto S*
Trophic and immunomodulatory effects of adipose tissue-derived stem cells in a preclinical murine model of endometriosis. Scientific Reports. 12:8031, 2022
Sekine M,Nishijima K,Nakagawa S,Suzuki Y,Murakami T,Kato Y,Umazume T,Tanaka H,Komatsu H,Doi K,Miura K,Kudo Y,Unno N,Kimura T,Enomoto T
Challenges facing workstyle reform for Japanese obstetricians and gynecologists revealed from time studies. J. Obstet. Gynaecol. Res. 48(7):1580-1590, 2022
Morizane S,Honda M,Kihara K,Yamamoto M,Komatsu H,Sato S,Hikita K, Tanishima S,Nakane H,Kurosaki M,Kaidoh T,Takenaka A
Laparoscopic pelvic lymph node dissection in cadaver surgical training from the combined perspectives of urologists, gastroenterologists and gynecologists improves overall knowledge and technique: initial experience of multidisciplinary cadaver surgical training at a single institution in Japan. Anat Sci Int. 97(3):303-306, 2022
Iida Y,Komatsu H*,Okawa M,Osaku D,Nosaka K,Sato S,Oishi T, Taniguchi F,Harada T
Is Adjuvant Chemotherapy Necessary in Patients with Early Endometrial Cancer? Yonago Acta Med. 22:65(1):82-87, 2022
Chikumi J,Oishi T*,Nakaso T,Sawada M,Kudoh A,Komatsu H,Sato S, Taniguchi F, Harada T
Endometrial Cancer Arising in Adenomyosis That Could Not Be Diagnosed by Endometrial Biopsy: A Case Report. Yonago Acta Med. 29:65(1):106-110, 2022

2021年

Komatsu H, Fuminori T, Tasuku H. Immunology and the management of endometriosis. Anti-inflammatory reagents: the role of NF-κB. Immunology of Endometriosis; Pathogenesis and Management. 1st Edition - December 10, 2021.
Komatsu H, Nogami Y (equal contribution), Makabe T, Hasegawa Y, Yokoyama Y, Kawana K*, Katabuchi H, The COVID-19 Task Force of the Japan Society of Gynecologic Oncology Impact of COVID-19 on gynecologic cancer treatment in Japan: a nationwide survey by the Japan Society of Gynecologic Oncology (JSGO). J Gynecol Oncol. 33(1): e8. 2021.
Osaku D, Oishi T*, Iida Y, Kawamura N, Komatsu H, Kudoh H, Chikumi J, Sato S, Harada T Differential expression of estrogen receptor subtypes in ovarian high-grade serous carcinoma and clear cell carcinoma. Reprod Med Biol. 23;20(4): 467-476. 2021.
Osaku D, Komatsu H*, Okawa M, Iida Y, Sato S, Oishi T, Harada T. Re-classification of uterine cervical cancer cases treated with radical hysterectomy based on the 2018 FIGO staging system. Taiwanese Journal of Obstetrics & Gynecology. 60(6): 1054-1058. 2021.
Okawa M, Komatsu H*(equal contribution), Iida Y, Osaku D, Sato S, Oishi T, Harada T Evaluating the efficacy and safety of ureteral stent placement as a preoperative procedure for gynecological cancer surgeries: a retrospective cohort study. J. Obstet. Gynaecol. Res. 47(8): 2752-2757. 2021.
Komatsu H, Watari H*, Onodera Y, Suemitsu T, Nakagawa S, Kusabiraki T, Matoba Y, Ihira K, Yanaihara N, Banno K, Okamoto A, Shozu M, Kimura T, and ※MIRAI Committee members. ※Iwase H, Yamagami W, Umazume T, Koga K, Kondo E, Sekine M, Nishigaya Y, Hasegawa J, Baba T, Hayashi M Initiatives and achievements of the Japanese Society of Obstetrics and Gynecology, Obstetrics and Gynecology MIRAI Committee 2020. J. Obstet. Gynaecol. Res. 2021 https://doi.org/10.1111/jog.14734.
Onodera Y, Matoba Y*, Suemitsu T, Shinagawa M, Sugita Y, Mayama M, Komatsu H, Yanaihara N, Banno K, Shozu M, Watari H. A survey of Japanese interns to prepare for mandatory clinical training in obstetrics and gynecology. J. Obstet. Gynaecol. Res. 2021 https://doi.org/10.1111/jog.14766.
Mayama M, Sekine M*, Onodera Y, Suemitsu T, Maeda Y, Nakano K, Sugita Y, Ogura J, Ohsuga T, Kodera C, Murakami T, Kido M, Suzuki Y, Shibata A, Nishijima K, Umazume T, Nakagawa S, Unno N, Komatsu H, Shozu M, Enomoto T, Watari H. Attitudes toward overtime work and self-training: A survey on obstetricians and gynecologists in Japan. J. Obstet. Gynaecol. Res. Vol. 47, No. 5: 1666–1674, May 2021.
Osaku D, Taniguchi F*, Komatsu H, Harada T. Calcified ovarian fibromas complicated with basal cell nevus syndrome: A Case Report. Gynecology and Minimally Invasive Therapy 2021. In press.

2020年

Komatsu H*, Banno K, Yanaihara N, Kimura T* and Board members of Japan Society of Obstetrics and Gynecology* Board members of Japan Society of Obstetrics and Gynecology: Aoki D, Kato Kiyoko, Ikeda T, Osuga Y, Okamoto A, Mandai M, Yaegashi N, Mikami M, Kudo Y, Sekizawa A, Enomoto T, Kamei Y, Kobayashi Y, Koyama M, Samejima H, Sibahara H, Syozu M, Sugino A, Takeshita T, Nagase S, Fuji T, Maeda N, Miyamoto S, Watari H. Prevention and practice during the COVID-19 emergency declaration period in Japanese Obstetrical/Gynecological facilities. J. Obstet. Gynaecol. Res. 46(11):2237-2241. 2020
Komatsu H*, Iida Y, Osaku D, Shimogai R, Chikumi J, Sato S, Oishi T, Harada T. Effects of pretreatment radiological and pathological lymph node statuses on prognosis in patients with ovarian cancer who underwent interval debulking surgery with lymphadenectomy following neoadjuvant chemotherapy. J. Obstet. Gynaecol. Res. 47(1):152-158. 2020
Taniguchi F, Tokita Y, Ota I, Yamane E, Komatsu H, Azuma Y, Sato E, Endo Y, Sunada H, Harada T. Efficacy of Tokishakuyakusan add-on therapy with low dose oral contraceptive pills on endometriosis patients with dysmenorrhea. J. Obstet. Gynaecol. Res. 46(11):2280-2286. 2020
Okawa M, Komatsu H*, Osaku D, Sawada M, Kudoh A, Shimogai R, Chikumi J, Sato S, Oishi T, Harada T. Efficacy of Panniculectomy-Combined Surgery in Superobese Patients with Endometrial Cancer: A case report and literature review. International Journal of Surgery Case Reports, Vol72, 99-103. 2020
Komatsu H*, Oishi T, Osaku D, Kudoh A, Shimogai R, Chikumi J, Sato S, Harada T. Long term evaluation of renal function and neurogenic bladder after radical hysterectomy in patients with uterine cervical cancer. J. Obstet. Gynaecol. Res. 2020
Komatsu H*, Shimada M, Osaku D, Deura I, Sato S, Oishi T, Harada T. Deep vein thrombosis and serum D-dimer after pelvic lymphadenectomy in gynecological cancer. Int J Gynecol Cancer; 0:1–5. 2020
Miyamoto K, Komatsu H*, Nagaya Y, Tsukihara S, Sarugami M, Osaku D, Taniguchi F, Harada T, Kanamori Y. Changes in serum D-dimer level and effect of enoxaparin sodium after a cesarean section: A retrospective study. J Matern Fetal Neonatal Med. 11:1-6. 2020
Hasegawa K, Shimada M, Takeuchi S, Fujiwara H, Imai Y, Iwasa N, Wada S, Eguchi H, Oishi T, Sugiyama T, Suzuki M, Nishiyama M, Fujiwara K. A phase 2 study of intraperitoneal carboplatin plus intravenous dose-dense paclitaxel in front-line treatment of suboptimal residual ovarian cancer. Br J Cancer. 2020 Mar;122(6):766-770.

2019年

Nagata H, Komatsu H*, Nagaya Y, Tsukihara S, Sarugami M, Harada T, Kanamori Y. Comparison of Total Laparoscopic Hysterectomy and Abdominal Total Hysterectomy in Patients with Benign Disease: A Retrospective Cohort Study. Yonago Acta Medica. 25;62(4):273-277. 2019
Okuno K*, Yoneda N, Nishimura R, Sano H, Ueyama J, Komatsu H, Harada T, Matsushita M, Kuwamoto S, Horie Y, Kanzaki S. Juvenile Granulosa Cell Tumor with Elevated Peripheral Interleukin-6 Level Shows Prolonged Fever and Delayed Puberty. Yonago Acta Medica; 62(3):263–267. 2019
Deura I, Shimada M, Azuma Y, Komatsu H, Nagira K, Sawada M, Harada T. Comparison of laparoscopic surgery and conventional laparotomy for surgical staging of patients with presumed low-risk endometrial cancer: The current state of Japan. Taiwanese Journal of Obstetrics and Gynecology, Vol58, Issue 1, 99-104. 2019
Sawada M, Oishi T, Komatsu H, Sato S, Chikumi J, Nonaka M, Kudoh A, Osaku D, Harada T. Serum Vascular endothelial growth factor A and vascular endothelial growth factor receptor 2 as prognostic biomarkers for uterine cervical cancer. Int J Clin Oncol. 2019 Dec;24(12):1612-1619.
Matsuo K, Cripe J, Kurnit K, Kaneda M, Garneau A, Glaser G, Nizam A, Schillinger R, Kuznicki M, Yabuno A, Yanai S, Garofalo D, Suzuki J, St Laurent J, Yen T, Y Liu A, Shida M, Kakuda M, Oishi T, Nishio S, Marcus J, Adachi S, Kurokawa T, Ross M, Horowitz M, Johnson M, Kim M, Melamed A, Machado K, Yoshihara K, Yoshida Y, Enomoto T, Ushijima K, Satoh S, Ueda Y, Mikami M, Rimel B, Stone R, Growdon W, Okamoto A, Guntupalli S, Hasegawa K, Shahzad M, Im D, Frimer M, Gostout B, Ueland F, Nagao S, Soliman P, Thaker P, Wright J, Roman L. Recurrence, death, and secondary malignancy after ovarian conservation for young women with early-stage low-grade endometrial cancer. Gynecol Oncol. 2019 Oct;155(1):39-50.
Komatsu H, Oishi T, Sato S, Osaku D, Sawada M, Kudoh A, Nonaka M, Sato S, Shimada M, Itamochi H, Harada T. Evaluating chemotherapy-induced nausea and vomiting and food intake in patients with gynecologic cancer. Anticancer Res. 2019 Aug;39(8):4555-4560.
Horita K, Kurosaki H, Nakatake M, Kuwano N, Oishi T, Itamochi H, Sato S, Kono H, Ito M, Hasegawa K, Harada T, Nakamura T. lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer. Mol Ther Oncolytics. 2019 Mar 26; 13:35-48.
Osaku D, Taniguchi F, Moriyama M, Sato S, Oishi T, Harada T. Retroperitoneal Endometrioid Carcinoma Arising from Ureteral Endometriosis. Case Rep Obstet Gynecol. 2019 Jun 10; 2019:9273858.
Komatsu H*, Taniguchi F, Nagata H, Nakaso T, Nagaya Y, Tukihara S, Sarugami M, Harata T, Kanamori Y. Retrospective evaluation of the crucial factor in total laparoscopic hysterectomy by using video review. Laparosc Surg; 3:23. 2019
Komatsu H*, Tsukihara S, Sato S, Sarugami M, Oishi T, Taniguchi F, Harada T, Kanamori Y. Training in the Departments of Urology and Surgery for Gynecologists in Japan. Yonago Acta Medica; 62(2):198–203. 2019
Komatsu H*, Taniguchi F, Harada T, Nakaso T, Nishimura N, Tsukihara S, Sarugami M, Harada T, Kanamori Y. Re-evaluation of Urinary Trypsin Inhibitor on Pregnancy Course in Patients with Threatened Preterm Delivery: A Single-Center Retrospective Study. Yonago Acta Medica; 62(2):198–203. 2019

2018年

Nonaka M, Sato S, Osaku D, Sawada M, Kudoh A, Chikumi J, Sato S, Oishi T, Harada T. Recurrent colon perforation after discontinuation of bevacizumab for ovarian cancer. Gynecol Oncol Rep. 2018 Aug 24; 26:21-23.
Komatsu H, Oishi T, Osaku D, Sawada M, Kudoh A, Nonaka M, Chikumi J, Sato S, Harada T. Significance of high-risk human papillomavirus testing for atypical glandular cells on cervical cytology. Acta Cytol. 2018;62(5-6):405-410.
Fujii S, Nosaka K, Mukuda N, Fukunaga T, Sato S, and Ogawa T. MR Imaging of an Intramural Adenosarcoma with Pathologic Correlation. Magn Reson Med Sci. 2018 Jan 10;17(1):1-2.

2017年

Komatsu H, Oishi T, Itamochi H, Shimada M, Sato S, Chikumi J, Sato S, Nonaka M, Sawada M, Wakahara M, Umekita Y, Harada T. Serum Vascular Endothelial Growth Factor-A as a Prognostic Biomarker for Epithelial Ovarian Cancer. Int J Gynecol Cancer. 2017 Sep;27(7):1325-1332.

2016年

Nosaka K, Komatsu H, Oishi T, Horie Y, Harada T, Umekita Y. A Case of Dedifferentiated Leiomyosarcoma of the Uterus. Int J Pathol Clin Res. 2016 2:049.
Shimada M, Sato S, Oishi T, Itamochi H, Kigawa J, Takeshima N, Aoki D, Aoki Y, Nambu Y, Ochiai K. Feasibility study on combination chemotherapy using nogitecan hydrochloride (topotecan) and cisplatin for patients with metastatic, persistent, or recurrent uterine cervical cancer. Int J Clin Oncol. 2016 Oct;21(5):969-974.
Sato S, Itamochi H, Oumi N, Chiba Y, Oishi T, Shimada M, Sato S, Chikumi J, Nonaka M, Kudoh A, Komatsu H, Harada T, Sugiyama T. Establishment and characterization of a novel ovarian clear cell carcinoma cell line, TU-OC-2, with loss of ARID1A expression. Hum Cell. 2016 Oct;29(4):181-7.
Kudoh A, Sato S, Itamochi H, Komatsu H, Nonaka M, Sato S, Chikumi J, Shimada M, Oishi T, Kigawa J, Harada T. Human papillomavirus type-specific persistence and reappearance after successful conization in patients with cervical intraepithelial neoplasia. Int J Clin Oncol. 2016 Jun;21(3):580-7
Oumi N, Itamochi H, Komatsu H, Oishi T, Shimada M, Sato S, Chikumi J, Sato S, Nonaka M, Kudoh A, Harada T. Establishment and mutation analysis of a novel malignant peritoneal mesothelioma cell line, TU-MM-1, using whole genome sequencing. Hum Cell. 2016 Jan;29 (1):46-51.

2015年

Nosaka K, Horie Y, Shiomi T, Itamochi H, Oishi T, Shimada M, Sato S, Sakabe T, Harada T, Umekita Y. Cytoplasmic Maspin Expression Correlates with Poor Prognosis of Patients with Adenocarcinoma of the Uterine Cervix. Yonago Acta Med. 2015 Dec;58(4):151-6.
Itamochi H, Oumi N, Oishi T, Shoji T, Fujiwara H, Sugiyama T, Suzuki M, Kigawa J, Harada T. Loss of ARID1A expression is associated with poor prognosis in patients with stage I/II clear cell carcinoma of the ovary. Int J Clin Oncol. 2015 Oct;20(5):967-73.
Itamochi H, Oumi N, Oishi T, Taniguchi F, Shoji T, Fujiwara H, Sugiyama T, Suzuki M, Kigawa J, Harada T. Fibroblast growth factor receptor 2 is associated with poor overall survival in clear cell carcinoma of the ovary and may be a novel therapeutic approach. Int J Gynecol Cancer. 2015 May;25(4):570-6.

2014年

Deura I, Shimada M, Hirashita K, Sugimura M, Sato S, Sato S, Oishi T, Itamochi H, Harada T, Kigawa J. Incidence and risk factors for lower limb lymphedema after gynecologic cancer surgery with initiation of periodic complex decongestive physiotherapy. Int J Clin Oncol. 2014 Jul 4. [Epub ahead of print]
Oishi T, Itamochi H, Kudoh A, Nonaka M, Kato M, Nishimura M, Oumi N, Sato S, Naniwa J, Sato S, Shimada M, Kigawa J, Harada T. The PI3K/mTOR dual inhibitor NVP-BEZ235 reduces the growth of ovarian clear cell carcinoma. Oncol Rep. 2014 Aug;32(2):553-8.
Kudoh A, Oishi T, Itamochi H, Sato S, Naniwa J, Sato S, Shimada M, Kigawa J, Harada T. Dual inhibition of phosphatidylinositol 3'-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach for mucinous adenocarcinoma of the ovary. Int J Gynecol Cancer. 2014 Mar;24(3):444-53.
Itamochi H, Nishimura M, Oumi N, Kato M, Oishi T, Shimada M, Sato S, Naniwa J, Sato S, Kudoh A, Kigawa J, Harada T. Checkpoint kinase inhibitor AZD7762 overcomes cisplatin resistance in clear cell carcinoma of the ovary. Int J Gynecol Cancer. 2014 Jan;24(1):61-9.

2013年

Shimada M, Itamochi H, Kigawa J. Nedaplatin: a cisplatin derivative in cancer chemotherapy. Cancer Manag Res. 2013 May 8;5:67-76.
Uegaki K, Shimada M, Sato S, Deura I, Naniwa J, Sato S, Oishi T, Itamochi H, Harada T, Kigawa J. Outcome of stage IB2-IIB patients with bulky uterine cervical cancer who underwent neoadjuvant chemotherapy followed by radical hysterectomy. Int J Clin Oncol. 2013 Apr 17. [Epub ahead of print]
Itamochi H, Kato M, Nishimura M, Oumi N, Oishi T, Shimada M, Sato S, Naniwa J, Sato S, Nonaka M, Kudoh A, Terakawa N, Kigawa J, Harada T. Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene. Hum Cell. 2013 Feb 21. [Epub ahead of print]

2012年

Itamochi H, Kato M, Nishimura M, Oishi T, Shimada M, Sato S, Naniwa J, Sato S, Nonaka M, Kudoh A, Terakawa N, Kigawa J, Harada T. Establishment and characterization of a novel ovarian serous adenocarcinoma cell line, TU-OS-4, that overexpresses EGFR and HER2. Hum Cell. 2012 Dec;25(4):111-5.
Itamochi H, Kigawa J. Clinical trials and future potential of targeted therapy for ovarian cancer. Int J Clin Oncol. 2012 Oct;17(5):430-40.
Nonaka M, Itamochi H, Kawaguchi W, Kudoh A, Sato S, Uegaki K, Naniwa J, Sato S, Shimada M, Oishi T, Terakawa N, Kigawa J, Harada T. Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells. Int J Gynecol Cancer. 2012 Jul;22(6):922-9.
Shimada M, Fujiwara H, Sato S, Oishi T, Itamochi H, Machida S, Takei Y, Harada T, Suzuki M, Kigawa J. Area under the curve calculation of nedaplatin dose used in combination chemotherapy with irinotecan in a phase I study of gynecologic malignancies. Cancer Chemother Pharmacol. 2012 Jul;70(1):33-8.
Minagawa Y, Shimada M, Itamochi H, Sato S, Sato S, Okada M, Kitada F, Kigawa J. Feasibility study on biweekly paclitaxel treatment as maintenance chemotherapy in advanced müllerian carcinoma. Gynecol Obstet Invest. 2012;73(4):272-6.
Bartholomeusz C, Oishi T, Saso H, Akar U, Liu P, Kondo K, Kazansky A, Krishnamurthy S, Lee J, Esteva FJ, Kigawa J, Ueno NT. MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model. Mol Cancer Ther. 2012 Feb;11(2):360-9.
Sato S, Fujiwara H, Oishi T, Shimada M, Machida S, Takei Y, Itamochi H, Suzuki M, Kigawa J. Evaluation of a formula for individual dosage of nedaplatin based on renal function. Cancer Chemother Pharmacol. 2012 Mar;69(3):599-603.

2011年

Itamochi H, Yoshida T, Walker CL, Bartholomeusz C, Aoki D, Ishihara H, Suzuki N, Kigawa J, Terakawa N, Ueno NT. Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27. Gynecol Oncol. 2011 Sep;122(3):641-7.
Itamochi H, Oishi T, Shimada M, Sato S, Uegaki K, Naniwa J, Sato S, Nonaka M, Terakawa N, Kigawa J, Harada T. Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cancer cells induced by etoposide through upregulation of c-Jun. Clin Cancer Res. 2011 Jul 15;17(14):4742-50.

2009年

Sato S, Itamochi H, Shimada M, Fujii S, Naniwa J, Uegaki K, Sato S, Nonaka M, Ogawa T, Kigawa J. Preoperative and intraoperative assessments of depth of myometrial invasion in endometrial cancer. Int J Gynecol Cancer. 2009 Jul;19(5):884-7.
Sato S, Itamochi H, Kigawa J, Oishi T, Shimada M, Sato S, Naniwa J, Uegaki K, Nonaka M, Terakawa N. Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: a potential treatment strategy. Cancer Sci. 2009 Mar;100(3):546-51.

2008年

Kawaguchi W, Itamochi H, Kigawa J, Kanamori Y, Oishi T, Shimada M, Sato S, Sato S, Terakawa N. Chemotherapy consisting of paclitaxel and carboplatin benefits a patient with malignant mixed müllerian tumor of the fallopian tube. Int J Clin Oncol. 2008 Oct;13(5):461-3.
Shimogai R, Kigawa J, Itamochi H, Iba T, Kanamori Y, Oishi T, Shimada M, Sato S, Kawaguchi W, Sato S, Terakawa N. Expression of hypoxia-inducible factor 1alpha gene affects the outcome in patients with ovarian cancer. Int J Gynecol Cancer. 2008 May-Jun;18(3):499-505.
Itamochi H, Kigawa J, Terakawa N. Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma. Cancer Sci. 2008 Apr;99(4):653-8. Review.
Kawaguchi W, Itamochi H, Kigawa J, Kanamori Y, Oishi T, Shimada M, Sato S, Shimogai R, Sato S, Terakawa N. Simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3'-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma. Cancer Sci. 2007 Dec;98(12):2002-8.

2007年

Oishi T, Itamochi H, Kigawa J, Kanamori Y, Shimada M, Takahashi M, Shimogai R, Kawaguchi W, Sato S, Terakawa N. Galectin-3 may contribute to Cisplatin resistance in clear cell carcinoma of the ovary. Int J Gynecol Cancer. 2007 Sep-Oct;17(5):1040-6.
Naniwa J, Kigawa J, Kanamori Y, Itamochi H, Oishi T, Shimada M, Shimogai R, Kawaguchi W, Sato S, Terakawa N. Genetic diagnosis for chemosensitivity with drug-resistance genes in epithelial ovarian cancer. Int J Gynecol Cancer. 2007 Jan-Feb;17(1):76-82.
Itamochi H, Kigawa J, Kanamori Y, Oishi T, Bartholomeusz C, Nahta R, Esteva FJ, Sneige N, Terakawa N, Ueno NT. Adenovirus type 5 E1A gene therapy for ovarian clear cell carcinoma: a potential treatment strategy. Mol Cancer Ther. 2007 Jan;6(1):227-35.