A hypothesis of Langerhans cell histiocytosis

based on our data

A hypothesis of Langerhans cell histiocytosis (LCH)
仮説（in Japanese）

  Ongoing debate: Reactive disease?  or Neoplastic disease?

  Our hypothesis: Reactive and (on) Neoplastic disease

      an inflammatory process driven by LCH cells 
which have underlying neoplastic potential such as aberrant BRAF signaling

or LCH subtypes are defined by overreaction against unknown triggers
with an underlying oncogenic potential
  candidate triggers of overreaction: Merkel cell polyomavirus
         cigarette smoking
                                                                              BCG? 
 
cf. 1.:  Mutation causes a kind of reactive disease
(familial hemophagocytic lymphohistiocytosis)
cf. 2.: Overreaction against dermal resident
                         (an endogenous infection caused by hypersensitivity) 
cf. 3.:   MALT lymphoma and H. pylori 
 
cf. 4.:  Langerhans cell sarcoma 
 
Correspondence:
Ichiro Murakami, MD, PhD
Division of Molecular Pathology
Faculty of Medicine
Tottori University
Murakami I. Commentary. J Cranio Max Dis 2013;2:149-50

Acute-phase ITIH4 levels distinguish multi-system from single-system Langerhans cell histiocytosis via plasma peptidomics.