鳥取大学大学院医学系研究科 機能再生医科学専攻　遺伝子再生医療学講座再生医療学部門

[2018年]

Li P, Kurata Y, Endang M, Ninomiya H, Higaki K, Taufiq F, Morikawa K, Shirayoshi Y, Horie M, Hisatome I.

Restoration of mutant hERG stability by inhibition of HDAC6.

J Mol Cell Cardiol. (2018) 115:158-169.

 

Kuwabara M, Hisatome I, Niwa K, Hara S, Roncal-Jimenez CA, Bjornstad P, Nakagawa T, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Rodriguez-Iturbe B, Ohno M, Lanaspa MA, Johnson RJ.

Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study.

Hypertension. (2018) 71:78-86.

 

Yamauchi K, Li J, Morikawa K, Liu L, Shirayoshi Y, Nakatsuji N, Elliott DA, Hisatome I, Suemori H.

Isolation and characterization of ventricular-like cells derived from NKX2-5eGFP/w and MLC2vmCherry/w double knock-in human pluripotent stem cells.

Biochem Biophys Res Commun. (2018) 495:1278-1284.

 

 

Tanno S, Yamamoto K, Kurata Y, Adachi M, Inoue Y, Otani N, Mishima M, Yamamoto Y, Kuwabara M, Ogino K, Miake J, Ninomiya H, Shirayoshi Y, Okada F, Yamamoto K, Hisatome I.

Protective Effects of Topiroxostat on an Ischemia-Reperfusion Model of Rat Hearts.

Circ J. 2018 Mar 23;82(4):1101-1111.

 

Satoshi Miyazaki, Tetsushi Sakuragi, Toshihiro Hamada, Shinobu Sugihara, Daeho Park , Kazuoki Inoue, Einosuke Mizuta, Yasutaka Yamamoto, Akira Ohtahara, Masanari Kuwabara, Hiromi Sakaguchi, Yoshihito Nozaka, Senzou Kishida, Kazuhide Ogino, Masahiko Kato , Shin-ichi Taniguchi, Akio Yoshida, Haruaki Ninomiya, Kazuhiro Yamamoto and Ichiro Hisatome.

Effects of Irbesartan on Uric Acid Metabolism in Patients with Treated Essential Hypertension

Vasc Fail 2018; 2: 11-19

 

Kuwabara M, Borghi C, Cicero AFG, Hisatome I, Niwa K, Ohno M, Johnson RJ, Lanaspa MA.

Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: A five-year cohort study in Japan.

Int J Cardiol. 2018 Jun 15;261:183-188.

 

Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI. Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects. Nutrients. 2018 Aug 3;10(8). pii: E1011.

Jensen T, Niwa K, Hisatome I, Kanbay M, Andres-Hernando A, Roncal-Jimenez CA, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ, Kuwabara M.

Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver.

Sci Rep. 2018 Aug 6;8(1):11735.

 

Shogo Tanno, Shinobu Sugihara, Kenshiro Yamamoto, Maya Adachi, Yumiko Inoue, Naoyuki Otani, Kazuhiko Iituka, Kazuyoshi Ogura, Masaru Kato, Junichiro Miake, Kazuhide Ogino, Motomazu Tsuneto, Akio Yoshida, Yasuaki Shirayoshi, Masanari Kuwabara, Kazuhiro Yamamoto, Haruaki Ninomiya and Ichiro Hisatome.

Pretreatment with topiroxostat and irbesartan improve cardiac function after myocardial infarction of rats.

Vasc Fail 2018 2;2;24-29

 

Yamaguchi S, Nambu A, Numata T, Yoshizaki T, Narushima S, Shimura E, Hiraishi Y, Arae K, Morita H, Matsumoto K, Hisatome I, Sudo K, Nakae S.

The roles of IL-17C in T cell-dependent and -independent inflammatory diseases.

Sci Rep. 2018 Oct 24;8(1):15750.

 

Yamamoto K, Kurata Y, Inoue Y, Adachi M, Tsuneto M, Miake J, Ogino K, Ninomiya H, Yoshida A, Shirayoshi Y, Suyama Y, Yagi S, Nishimura M, Yamamoto K, Hisatome I.

Pretreatment with an angiotensin II receptor blocker abolished ameliorating actions of adipose-derived stem cell sheets on cardiac dysfunction and remodeling after myocardial infarction.

Regen Ther. 2018 Sep 19;9:79-88.

 

【英文総説】

1) Maruhashi T, Hisatome I, Kihara Y, Higashi Y. Hyperuricemia and endothelial function: From molecular background to clinical perspectives. Atherosclerosis. 2018 Nov;278:226-231.

 

【Editorial】

1) Kuwabara M, Kanbay M, Hisatome I. Uric Acid and Hypertension Because of Arterial Stiffness. Hypertension. 2018 Jul 9. pii: HYPERTENSIONAHA.118.11496.

2) Kuwabara M, Hisatome I. Gender Difference in the Association Between Uric Acid and Atrial Fibrillation. Circ J. 2018 Dec 25;83(1):27-29.

 

[2017年]

Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ.

"Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study.

Obesity (Silver Spring). (2017) 25:1997-2008.

 

Miake J, Notsu T, Higaki K, Hidaka K, Morisaki T, Yamamoto K, Hisatome I.

Cited4 is related to cardiogenic induction and maintenance of proliferation capacity of embryonic stem cell-derived cardiomyocytes during in vitro cardiogenesis.

PLoS One. (2017) 12:e0183225.

 

Ikeda N, Nakazawa N, Kurata Y, Yaura H, Taufiq F, Minato H, Yoshida A, Ninomiya H, Nakayama Y, Kuwabara M, Shirayoshi Y, Hisatome I.

Tbx18-positive cells differentiated from murine ES cells serve as proepicardial progenitors to give rise to vascular smooth muscle cells and fibroblasts.

Biomed Res. (2017) 38:229-238.

 

Bahrudin U, Unno M, Nishio K, Kita A, Li P, Kato M, Inoue M, Tsujitani S, Murakami T, Sugiyama R, Saeki Y, Obara Y, Tanaka K, Yamaguchi H, Sakane I, Kawata Y, Itoh T, Ninomiya H, Hisatome I, Morimoto Y.

Inhibitory effects of local anesthetics on the proteasome and their biological actions.

Sci Rep. (2017) 7:5079.

 

Onohara T, Hisatome I, Kurata Y, Li P, Notsu T, Morikawa K, Otani N, Yoshida A, Iitsuka K, Kato M, Miake J, Ninomiya H, Higaki K, Shirayoshi Y, Nishihara T, Itoh T, Nakamura Y, Nishimura M.

Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells.

J Arrhythm. (2017) 33:226-233.

 

Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ.

Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study.

Hypertension. (2017) 69:1036-1044.

 

Wahyuningsih H, K Cayami F, Bahrudin U, A Sobirin M, Ep Mundhofir F, Mh Faradz S, Hisatome I.

Optimization of PCR Condition: The First Study of High Resolution Melting Technique for Screening of APOA1 Variance.

Yonago Acta Med. (2017) 60:24-30.

 

Kuwabara M, Bjornstad P, Hisatome I, Niwa K, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Milagres T, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ.

Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function.

Am J Nephrol. (2017) 45:330-337.

 

Kuwabara M, Hisatome I, Roncal-Jimenez CA, Niwa K, Andres-Hernando A, Jensen T, Bjornstad P, Milagres T, Cicerchi C, Song Z, Garcia G, Sánchez-Lozada LG, Ohno M, Lanaspa MA, Johnson RJ.

Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study.

PLoS One. (2017) 12:e0169137.

 

Yuan H, Hu Y, Zhu Y, Zhang Y, Luo C, Li Z, Wen T, Zhuang W, Zou J, Hong L, Zhang X, Hisatome I, Yamamoto T, Cheng J.

Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells.

Mol Cell Endocrinol. (2017) 443:138-145.

 

Kuwabara M, Niwa K, Nishihara S, Nishi Y, Takahashi O, Kario K, Yamamoto K, Yamashita T, Hisatome I.

Hyperuricemia is an independent competing risk factor for atrial fibrillation.

Int J Cardiol. (2017) 231:137-142.

 

Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T.

Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models.

Am J Physiol Heart Circ Physiol. (2017) 312:H106-H127.

 

[2016年以前] 

Luo C, Lian X, Hong L, Zou J, Li Z, Zhu Y, Huang T, Zhang Y, Hu Y, Yuan H, Wen T, Zhuang W, Cai B, Zhang X, Hisatome I, Yamamoto T, Huang J, Cheng J.

High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1.

Cell Physiol Biochem. (2016) 40:538-548.

 

Peili Li, Haruaki Ninomiya, Yasutaka Kurata, Masaru Kato, Junichiro Miake, Yasutaka Yamamoto, Osamu Igawa, Akira Nakai, Katsumi Higaki, Futoshi Toyoda, Jie Wu, Minoru Horie, Hiroshi Matsuura, Akio Yoshida, Yasuaki Shirayoshi, Masayasu Hiraoka, Ichiro Hisatome.

Reciprocal Control of hERG Stability by Hsp70 and Hsc70 with Implication for Restoration of LQT2 Mutant Stability.

Circ Res. 2011 Feb 18;108(4):458-68.

 

YK Ting, K Morikawa, Y Kurata, PL Li, U Bahrudin, E Mizuta, M Kato, J Miake, Y Yamamoto, A Yoshida, M Murata, T Inoue, A Nakai, G Shiota, K Higaki, E Nanba, H Ninomiya, Y Shirayoshi, I Hisatome.

Transcriptional activation of SAP97 by HSF-1 stabilizes Kv1.5 in HL-1 cells.

Br J Pharmacol. 2011 Apr;162(8):1832-1842.

 

Tanaka K, Yamamoto Y, Ogino K, Tsujimoto S, Saito M, Uozumi N, Shimizu T, Hisatome I.

Cytosolic Phospholipase A2{alpha} Contributes to Blood Pressure Increases and Endothelial Dysfunction Under Chronic NO Inhibition.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1133-8.

 

Higaki K, Li L, Bahrudin U, Okuzawa S, Takamura A, Yamamoto K, Adachi K, Paraguison RC, Takai T, Ikehata H, Tominaga L, Hisatome I, Iida M, Ogawa S, Matsuda J, Ninomiya H, Sakakibara Y, Ohno K, Suzuki Y, Nanba E.

Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency.

Hum Mutat. 2011 Jul;32(7):843-852.

 

Nishio R, Tsuchiya H, Yasui T, Matsuura S, Kanki K, Kurimasa A, Hisatome I, Shiota G.

Disrupted plasma membrane localization of equilibrative nucleoside transporter 2 in the chemoresistance of human pancreatic cells to gemcitabine (dFdCyd).

Cancer Sci. 2011 Mar;102(3):622-9.

 

Hoshikawa Y, Kanki K, Ashla AA, Arakaki Y, Azumi J, Yasui T, Tezuka Y, Matsumi Y, Tsuchiya H, Kurimasa A, Hisatome I, Hirano T, Fujimoto J, Kagechika H, Shomori K, Ito H, Shiota G.

c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells. Cancer Sci. 2011 May;102(5):934-41

 

Ikeda R, Ishii K, Hoshikawa Y, Azumi J, Arakaki Y, Yasui T, Matsuura S, Matsumi Y, Kono Y, Mizuta Y, Kurimasa A, Hisatome I, Friedman SL, Kawasaki H, Shiota G.

Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation.

Inflamm Res. 2011 Jun;60(6):597-604.

 

Li P, Tanaka S, Ichiyanagi T, Ninomiya H, Ting Y, Utami SB, Aimi T, Shirayoshi Y, Miake J, Hisatome I.

Novel effects of extracts from poisonous mushrooms on expression and function of the human ether-a-go-go-related gene channel.

Biol Pharm Bull. 2011;34(9):1474-80.

 

Bahrudin U, Morikawa K, Takeuchi A, Kurata Y, Miake J, Mizuta E, Adachi K, Higaki K, Yamamoto Y, Shirayoshi Y, Yoshida A, Kato M, Yamamoto K, Nanba E, Morisaki H, Morisaki T, Matsuoka S, Ninomiya H, Hisatome I.

Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading to electrophysiological dysfunction.

J Mol Biol. 2011 Nov 4;413(4):857-78.

 

Urashima T, Kurata Y, Miake J, Kato M, Ogura K, Yano A, Adachi M, Tanaka Y, Yamada K, Hamada T, Mizuta E, Kuwabara M, Kato M, Yamamoto Y, Ogino K, Yoshida A, Shirayoshi Y, Hisatome I.

Enhancing effects of salicylate on quinidine-induced block of human wild type and LQT3 related mutant cardiac Na+ channels.

Biomed Res. 2011 Oct;32(5):303-12