論文リスト


染色体工学に関連した研究領域別論文リスト
[ 2012年7月末現在：全論文リストは鳥取大学染色体工学研究センター 参照 ]


A: Microcell-chromosome-transfer and chromosome library（染色体導入と染色体ライブラリー）

  1. 押村光雄：マウスA9 蛋白質　核酸　酵素 33: 2411, 1988
  2. Koi M., Morita H., Shimizu M., Oshimura M.: Construction of mouse A9 clones containing a single human chromosome (X/autosome translocation) via micro-cell fusion. Jpn. J. Cancer Res., 80: 122-125, 1989
  3. Koi M., Shimizu M., Morita H., Yamada H., Oshimura, M.: Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion. Jpn. J. Cancer Res., 80: 413-418, 1989
  4. 波柴弘樹，押村光雄：染色体移入による癌形質の抑制 医学のあゆみ 151: 525-529, 1989
  5. 久郷裕之，押村光雄：がん抑制に係わる染色体同定のための微小核細胞融合法 Oncologia, 22: 103-106, 1989
  6. 山田秀人，児井　稔，押村光雄：癌抑制染色体同定のための単一染色体移入法 放射線科学 32: 15-20, 1989
  7. 押村光雄，児井　稔：微小核融合法による染色体移入 実験医学 7: 191-194, 1989
  8. Kugoh M.H., Koi M., Shimizu M., Yamada H., Oshimura M.: Technical notes for the transfer of chromosome tagged with a dominant selectable gene. Chromosome Information Service, 46: 25-27, 1989
  9. 押村光雄，清水素行：ミクロセル法 −がん形質抑制染色体の同定−蛋白質　核酸　酵素 35: 2402-2412, 1990
  10. Satoh H., Barrett J.C., Oshimura, M.: Introduction of new genetic markers on human chromosomes. Experimental Cell Res., 193: 5-11, 1991
  11. 清水素行，押村光雄：微小核細胞融合法を用いた染色体導入と単一染色体パネル作製への応用 蛋白質　核酸　酵素 36: 2226-2230, 1991
  12. 中川ゆづき，押村光雄：染色体ライブラリー 組織培養 17: 473-477, 1991
  13. 黒木登志夫，谷口克，押村光雄：細胞工学ハンドブック 実験医学 98-99, 1992
  14. 栗政明弘，押村光雄：微小核融合による染色体移入 実験医学 12: 66-73, 1994
  15. Lee J-Y., Koi M., Stanbridge E. J., Oshimura M., Kumamoto A. T., Feinberg A.P.: Simple purification of human chromosomes to homogeneity using muntjac hybrid cells. Nature Genet., 7: 29-33, 1994
  16. 上島宗之，篠原徳之，押村光雄：微小核細胞融合法を利用した染色体操作　組織培養，22: 41-46, 1996
  17. 上島宗之，押村光雄：微小核融合法による染色体導入法　組織培養工学　23:68-72, 1997
  18. Tanabe H., Nakagawa Y., Minegishi D., Hashimoto K., Tanaka N., Oshimura M., Sofuni T., Mizusawa H.: Human monochromosome hybrid cell panel characterized by FISH in the JCRB/HSRRB. Chromosome Res., 8: 319-34, 2000
  19. Horike S., Mitsuya K., Meguro M., Kotobuki N., Kashiwagi A., Notsu T., Schulz T.C., Shirayoshi Y., Oshimura, M.: Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in beckwith-wiedemann syndrome. Hum. Mol. Genet., 9: 2075-83, 2000
  20. Murakami Y., Uejima H., Fukuhara H., Maruyama T., Oshimura M., Sekiya, T.: Construction of human-rodent hybrid cells containing single transferable fragments of human chromosome 10p. J. Hum. Genet., 45: 370-373, 2000
  21. 堀家慎一，野津智美，押村光雄：微小核細胞融合法を利用した染色体工学　細胞，33:114-117, 2001
  22. Inoue J., Mitsuya K., Maegawa S., Kugoh H., Kadota M., Shinohara T., Nishihara S., Takehara S., Yamauchi K., Schulz T.C., Oshimura M.: Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6. J. Hum. Genet., 46: 137-145, 2001
  23. 甲斐義輝，香月宏康，押村光雄：動物細胞への染色体導入　実験医学別冊 12（培養細胞実験ハンドブック） 147-150, 2004
  24. 則兼聡子，井上敏昭，押村光雄：細胞融合法 実験医学別冊 12（培養細胞実験ハンドブック） 155-158, 2004

B: Chromosome engineering（染色体工学技術）

  1. Kuroiwa Y., Shinohara T., Notsu T., Tomizuka K., Yoshida H., Takeda S., Oshimura M., Ishida I.: Efficient modification of a human chromosome by telomere-directed truncation in high homologous recombination-proficient chicken DT40 cells. Nucleic Acid Res., 26: 3447-3448, 1998
  2. 野津智美，押村光雄　ニワトリB前駆細胞株DT40を用いた染色体改変　組織培養工学　24:549-552, 1998
  3. Kouprina, N., Ebersole, T., Koriabine, M., Pak, E., Rogozin, I.B., Katoh, M., Oshimura, M., Ogi, K., Peredelchuk, M., Solomon, G., Brown, W., Barrett, J.C., Larionov, V.: Cloning of human centromeres by transformation-associated recombination in yeast and generation of functional human artificial chromosomes. Nucl. Acids Res., 31: 922-934, 2003
  4. Katoh M., Ayabe F., Norikane S., Okada T., Masumoto H., Horike S., Shirayoshi Y., Oshimura M.: Construction of a novel human artificial chromosome vector for gene delivery. Biochem Biophys Res Commun. 20;321:280-90., 2004
  5. 綾部文明，香月康宏，押村光雄：染色体改変技術　実験医学別冊クロマチン染色体実験プロトコール 203-212, 2004
  6. 加藤基伸，押村光雄：ヒト21番染色体を用いたトップダウン方式によるヒト人工染色体ベクターの構築　細胞工学 23:188-192, 2004
  7. 押村光雄：遺伝子・機能再生医療を目指したヒト人工染色体の構築　痛風と核酸代謝28巻2号　P.143 2005
  8. Ayabe F., Katoh M., Inoue T., Kouprina N., Larionov V., Oshimura M.: A novel expression system for genomic DNA loci using a human artificial chromosome vector with transformation-associated recombination cloning. J Hum Genet., 50:592-9 2005
  9. Ishikawa Y., Tanaka N., Murakami K., Uchiyama T., Kumaki S, Tsuchiya S., Kugoh H., Oshimura M., Calos MP., Sugamura K.: Phage phiC31 integrase-mediated genomic integration of the common cytokine receptor gamma chain in human T-cell lines. J Gene Med.,8:646-53, 2006
  10. Kawahara M., Inoue T., Ren X., Sogo T., Yamada H., Katoh M., Ueda H., Oshimura M., Nagamune T.: Antigen-mediated growth control of hybridoma cells via a human artificial chromosome. Biochim Biophys Acta., 1770:206-12, 2007
  11. 香月康宏，押村光雄：幹細胞のゲノム操作；ヒト人工染色体ベクターの開発．ゲノム医学　Vol. 9 No. 3, 2009
  12. 黒崎　創，押村光雄：幹細胞へのヒト人工染色体導入－医学・薬学への応用－　最新医学　159-168, 2009
  13. Iida Y, Kim JH, Kazuki Y, Hoshiya H, Takiguchi M, Hayashi M, Erliandri I, Lee HS, Samoshkin A, Masumoto H, Earnshaw WC, Kouprina N, Larionov V, Oshimura M.: Human artificial chromosome with a conditional centromere for gene delivery and gene expression. DNA Res. 17:293-301. 2010
  14. 山口繁幸，大林徹也，香月康宏，押村光雄：ヒト人工染色体ベクターの利点とその応用，生化学，Vol. 82, No.9, p846-852, 2010
  15. Kazuki Y., Hoshiya H., Takiguchi M., Abe s., Iida Y., Osaki M., Katoh M., Hiratsuka M., Shirayoshi Y., Hiramatsu K., Ueno E., Kajitani N., Yoshino T., Kazuki K., Ishihara C., Takehara S., Tsuji S., Ejima F., Toyoda A., Sakaki Y., Larionov V., Kouprina N., Oshimura M.: Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Therapy 18:384-93, 2011
  16. Yamaguchi S., Kazuki Y., Nakayama Y, Nanba E., Oshimura M., Ohbayashi T.: A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector. Plos One. 6e17267, 2011
  17. Kim J.H., Kononenko A., Erliandri I., Kim T.A., Nakano M., Iida Y., Barrett J.C., Oshimura M., Masumoto H., Earnshaw W.C., Larionov V., Kouprina N.: Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells. Proc Natl Acad Sci USA, 2011
  18. Kakeda M., Nagata K., Osawa K., Matsuno H., Hiratsuka M., Sano A., Okazaki A., Shitara S., Nishikawa S., Masuya A., Hata T., Wako S., Osaki M., Kazuki Y., Oshimura M., Tomizuka K.: A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells. Biochem Biophys Res Commun. 415:439-44.2011

C: Tumor suppression（癌抑制）

  1. 押村光雄：マウスA9 蛋白質　核酸　酵素 33: 2411, 1988
  2. 児井　稔，押村光雄：SiHa 蛋白質　核酸　酵素 33: 2540-2541, 1988
  3. 堀川　泉，押村光雄：癌抑制染色体 BIOmedica, 4: 1104-1109, 1989
  4. Koi M., Morita H., Yamada H., Satoh H., Barrett J.C., Oshimura M.: Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa. Mol. Carcinogen., 2: 12-21, 1989
  5. 押村光雄，清水素行：がん抑制に働く染色体 BIOmedica, 4: 833-838, 1989
  6. 押村光雄：染色体移入による癌抑制　実験医学 7: 1377-1381, 1989
  7. Mori N., Yokota J., Oshimura M., Cavenee W.K., Mizoguchi H., Noguchi M., Shimosato Y., Sugimura T., Terada M.: Concordant deletions of chromosome 3p and loss of heterozygosity for chromosomes 13 and 17 in small cell lung carcinoma. Cancer Res., 49: 5130-5135, 1989
  8. Nagashima, Y., Ohaki, Y., Umeda, M., Oshimura, M., Misugi, K.: Establishment and characterization of an immature epithelial cell line (ENU-T-1) derived from a rat nephroblastoma. Virch. Archiv B Cell Pathol., 57: 383-392, 1989
  9. 押村光雄：染色体移入による造腫瘍性抑制に働く染色体の同定 環境変異原研究 11: 35-40, 1989
  10. Shimizu M., Yokota J., Mori N., Shuin T., Shinoda M., Terada M., Oshimura M.: Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line YCR. Oncogene, 5: 185-194, 1990
  11. Oshimura M., Kugoh H., Koi M., Shimizu M., Yamada H., Satoh H., Barrett, J.C.: Transfer of a normal human chromosome 11 suppresses tumorigenicity of some but not all tumor cell lines. J. Cell. Biochem., 42: 135-142, 1990
  12. Oshimura M., Kugoh M.H., Shimizu M., Yamada H., Hashiba H., Horikawa I., Sasaki M.: Multiple chromosomes carrying tumor suppressor activity, via microcell-mediated chromosome transfer, for various tumor cell lines. Genetic Basis for Carcinogenesis: Tumor Suppressor Genes and Oncogenes, Jpn. Sci. Soc. Press., Tokyo/Taylor & Francis, Ltd., London, (eds. Kunudson, A.G.Jr., et al.), pp. 249-257, 1990
  13. Yamada H., Wake N., Fujimoto S., Barrett J.C., Oshimura M.: Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer. Oncogene, 5: 1141-1147, 1990
  14. Kugoh M.H., Hashiba H., Shimizu M., Oshimura M.: Suggestive evidence for functionally distinct, tumor-suppressor genes on chromosomes 1 and 11 for a human fibrosarcoma cell line, HT1080. Oncogene, 5: 1637-1644, 1990
  15. Yamada H., Horikawa I., Hashiba H., Oshimura M.: Normal human chromosome 1 carries suppressor activity for various phenotypes of a Kirsten murine sarcoma virus-transformed NIH/3T3 cell line. Jpn. J. Cancer Res., 81: 1095-1100, 1990
  16. 佐々木雅弘，押村光雄：染色体移入による癌形質の抑制 実験医学 8: 833-836, 1990
  17. 押村光雄，清水素行：微小核細胞融合法を用いた癌抑制遺伝子の研究 日本臨床 48: 1856-1862, 1990
  18. Oshimura M., Kugoh H., Koi M., Shimizu M., Yamada H., Satoh H., Barrett J.C.: Transfer of a normal human chromosome 11 suppresses tumorigenicity of some but not all tumor cell lines. Genetic Mechanisms in Carcinogenesis and Tumor Progression, Wiley-Liss, Inc., pp.219-220, 1991
  19. Tanaka K., Oshimura M., Kikuchi R., Seki M., Hayashi T., Miyaki M.: Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or Nature, 349: 340-342, 1991
  20. Hoshino Y., Horikawa I., Oshimura M., Yuasa Y.: Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity. Biochem. Biophys. Res. Commun., 174: 298-304, 1991
  21. 堀川　泉，押村光雄：癌抑制遺伝子　−研究の現状と展望− 癌と化学療法 18: 153-159, 1991
  22. 久郷裕之，押村光雄：単一染色体移入による癌抑制遺伝子の解析 血液・腫瘍科 22: 425-430, 1991
  23. 押村光雄：染色体移入による癌抑制遺伝子に関する研究 代謝 ｢癌Õ91｣ 28: 179-184, 1991
  24. 押村光雄：癌抑制遺伝子 医科学大辞典補遺巻8　最新の医療情報 : 9-12, 1991
  25. 平塚正治，押村光雄：染色体移入による癌抑制遺伝子の研究 代謝 28: 203-211, 1991
  26. Oshimura, M.: Lessons learned from studies on tumor suppression by microcell-mediated chromosome transfer. Environ. Health Perspect., 93: 57-58, 1991
  27. 堀川　泉，押村光雄：癌抑制遺伝子への細胞工学的アプローチ 日本大腸肛門病会誌 44: 1214-1219, 1991
  28. 押村光雄：微小核細胞融合法による染色体移入 「内分泌学の進歩」 9: 125-131, 1991
  29. Loh W.E.,Jr., Scrable H.J., Livanos E., Arboleda M.J., Cavenee W.K., Oshimura M., Weissman B.E.: Human chromosome 11 contains two different growth suppressor genes for embryonal rhabdomyosarcoma. Proc. Natl. Acad. Sci. USA, 89: 1755-1759, 1992
  30. Ichikawa T., Ichikawa Y., Dong J., Hawkins A.L., Griffin C.A., Isaacs W.B., Oshimura M., Barrett J.C., Isaacs J.T.: Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. Cancer Res., 52: 3486-3490, 1992
  31. Oshimura M., Kurimasa A.: Studies on tumor suppression by microcell-mediated chromosome transfer. Excerpta Medica, 7: 52-54, 1992
  32. 紙谷秀規，押村光雄：Gliomaのがん抑制遺伝子 BIOmedica 7: 1077-1080, 1992
  33. Annab L.A., Dong J-T., Futreal P.A., Satoh H., Oshimura M., Barrett J.C.: Growth and transformation suppressor genes for BHK Syrian hamster cells on human chromosomes 1 and 11. Mol. Carcinogen., 6: 280-288, 1992
  34. Satoh H., Lamb P.W., Dong J-T., Everitt J., Boreiko C., Oshimura M., Barrett J.C.: Suppression of tumorigenicity of A549 lung adenocarcinoma cells by human chromosomes 3 and 11 introduced via microcell-mediated chromosome transfer. Mol. Carcinogen., 7: 157-164, 1993
  35. Tanaka K., Yanoshita R., Konishi M., Oshimura M., Maeda Y., Mori T., Miyaki M.: Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region. Oncogene, 8: 2253-2258, 1993
  36. 山本康孝，栗政明弘，押村光雄：染色体移入によってここまでわかった癌抑制遺伝子 臨床分子医学 1: 826-832, 1993
  37. Yoshida M.A., Shimizu M., Ikeuchi T., Tonomura A., Yokota J., Oshimura M.: In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell-fusion. Mol. Carcinogen., 9: 114-121, 1994
  38. Ichikawa T., Nihei N., Suzuki H., Oshimura M., Emi M., Nakamura Y., Hayata I., Isaacs J. T., Shimazaki J.: Suppression of metastasis of rat prostatic cancer by introducing human chromosome 8. Cancer Res., 54: 2299-2302, 1994
  39. Miyamoto S., Nishida M., Miwa K., Kato H., Imamura T., Barrett J.C., Shimizu M., Oshimura M., Wake, N.: Increased Actin cable organization after single chromosome introduction : association with suppression of in vitro cell growth rather than tumorigenic suppression. Mol. Carcinogen., 10: 88-96, 1994
  40. 大村　宏，押村光雄：癌抑制遺伝子1　検査と技術 22: 587-591, 1994
  41. 三浦典正，押村光雄：癌抑制遺伝子2　検査と技術 22: 719-724, 1994
  42. Zenklusen J.C., Oshimura M., Barrett J.C., Conti, C.J.: Inhibition of tumorigenicity of murine squamous cell carcinoma (SCC) cell line by a putative tumor suppressor gene on human chromosome 7. Oncogene, 9: 2817-2825, 1994
  43. 久郷裕之：ヒト線維肉腫細胞株（HT1080）のがん形質抑制に係わる正常1，11番染色体上遺伝子の量的効果の検討　米子医誌 45: 453-459, 1994
  44. Yamada H., Sasaki M., Honda T., Wake N., Boyd J., Oshimura M., Barrett, J. C.: Suppression of endometrial carcinoma cell tumorigenicity by human chromosome 18. Genes, Chromosomes and Cancer, 13: 18-24, 1995
  45. Horikawa I., Yamada H., Kugoh H., Yuasa Y., Suzuki M., Oshimura M.: Subchromosomal mapping of a putative transformation suppressor gene on human chromosome 1. Jpn. J. Cancer Res., 86: 444-450, 1995
  46. Horikawa I., Oshimura M.: A normal human chromosome 3 suppresses tumorigenicity of human cervical carcinoma cell line, SiHa. Chromosome Information Service, 58: 3-4, 1995
  47. Horikawa I., Tanaka H., Yuasa Y., Suzuki M., Shimizu M., Oshimura M.: Forced expression of YL-1 protein suppresses the anchorage-independent growth of Kirsten sarcoma virus-transformed NIH3T3 cells. Exp. Cell Res., 220: 11-17, 1995
  48. Nihei N., Ichikawa T., Kawana Y., Kuramochi H., Kugoh H., Oshimura M., Killary A.M., Rinker-Schaeffer C.W., Barrett J.C., Isaacs J.T., Shimazaki J.: Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10. Genes, Chromosomes and Cancer, 14: 112-119, 1995
  49. 押村光雄：発がん過程におけるがん抑制遺伝子の消失　西日本泌尿器科　57: 1149-1154, 1995
  50. Kamitani H., Horikawa I., Hori T., Oshimura M.: Growth suppression function of the human glioblastoma cell line, T98G via microcell-Mediated transfer of chromosome 17. Yonago Acta Medica, 38: 221-227, 1995
  51. Uzawa N., Yoshida M.A., Oshimura M., Ikeuchi T.: Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer. Oncogene, 11: 1994-2004, 1995
  52. 堀川　泉，押村光雄：遺伝子・染色体導入による癌抑制遺伝子研究　日本臨床， 53: 2647-2652, 1995
  53. Horikawa I., Okamoto A., Yokota J., Oshimura M.: Genetic heterogeneity of chromosome 11 associated with tumorigenicity in HeLa D98-OR Cells. Cancer Genet. Cytogenet., 85: 97-100, 1995
  54. Tanaka K., Kikuchi-Yanoshita R., Muraoka M., Konishi M., Oshimura M., Miyaki M.: Suppression of tuomorigenicity and invasiveness of colon carcinoma cells by introduction of normal chromosome 8p12-pter. Oncogene, 12: 405-410, 1996
  55. Ichikawa T., Nihei N., Kuramochi H., Kawana Y., Killary A.M., Rinker-Schaeffer C.W., Barrett J.C., Isaacs J.T., Kugoh H., Oshimura M., Shimazaki J.: Metastasis suppressor genes for prostate cancer. The Prostate Suppl., 6: 31-35, 1996
  56. Nihei N., Ichikawa T., Kawana Y., Kuramochi H., Kugoh H., Oshimura M., Hayata I., Shimazaki J., Ito H.: Mapping of metastasis suppressor gene(s) for rat prostate cancer on the short arm of human chromosome 8 by irradiated microcell-mediated chromosome transfer. Genes, Chromosomes & Cancer, 17: 260-268, 1996
  57. 田中宏美，押村光雄：テロメア・テロメレースと細胞老化　生体の科学　: 547-552, 1996
  58. Matsuda T., Sasaki M., Kato H., Yamada H., Cohen M., Barrett J.C., Oshimura M., Wake M.: Human chromosome 7 carries a putative tumor suppressor gene(s) involved in choriocarcinoma. Oncogene, 19: 2773-2781, 1997
  59. Uzawa N., Yoshida M.A., Hosoe S., Oshimura M., Amagasa T., Ikeuchi, T.: Functional evidence for involvement of multiple putative tumor suppressor genes on the short arm of chromosome 3 in human oral squamous cell carcinogenesis. Cancer Genet. Cytogenet., 107:125-131, 1998
  60. Nihei N., Ohta S., Kuramochi H., Kugoh H., Oshimura M., Barrett J.C., Isaacs J.T., Igarashi T., Ito H., Masai M., Ichikawa Y., Ichikawa, T.: Metastasis suppressor gene(s) for rat prostate cancer on the long arm of human chromosome 7. Genes, Chrom. & Cancer, 24: 1-8, 1998
  61. Kugoh H., Fujiwara M., Kihara K., Fukui I., Horikawa I., Schulz T.C., Oshimura M.: Cellular senescence of a human bladder carcinoma cell line (JTC-32) induced by a normal chromosome 11. Cancer Genet. Cytogenet., 116:158-163, 2000
  62. Ichikawa T., Hosoki S., Suzuki H., Akakura K., Igarashi T., Furuya Y., Oshimura M., Rinker-Schaeffer C.W., Nihei N., Barrett J.C., Isaacs J.T., Ito H.: Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer. Asian J. Androl., 2: 167-171, 2000
  63. Fukuhara H., Maruyama T., Nomura S., Oshimura M., Kitamura T., Sekiya T., Murakami Y.: Functional evidence for the presence of tumor suppressor gene on chromosome 10p15 in human prostate cancers. Oncogene, 20: 314-319, 2001
  64. Tanaka K., Shiota G., Meguro M., Mitsuya K., Oshimura M., Kawasaki H.: Loss of imprinting of long qt intronic transcript 1 in colorectal cancer. Oncology, 60: 268-273, 2001
  65. Hosoki S., Ota S., Ichikawa Y., Suzuki H., Ueda T., Naya Y., Akakura K., Igarashi T., Oshimura M., Nihei N., Barrett J.C., Ichikawa T., Ito H.: Suppression of metastasis of rat prostate cancer by introduction of human chromosome 13. Asian J. Androl., 4: 131-136, 2002
  66. Kugoh H., Nakamoto H., Inoue J., Funaki K., Barrett J.C., Oshimura M.: Multiple human chromosome carrying tumor-suppressor functions for the mouse melanoma cell line B16-F10, identified by micorcell-mediated chromosome transfer. Mol. Carcinog., 35: 148-156, 2002
  67. 久郷裕之，押村光雄：細胞工学からみた癌細胞　Med. Technol., 31: 93-97, 2003
  68. Lefter L.P., Sunamura M., Furukawa T., Takeda K., Kotobuki N., Oshimura M., Matsuno S., Horii A.: Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastastic phenotype. Clin. Cancer Res., 9: 5044-5052, 2003
  69. Yamanaka S., Sunamura M., Furukawa T., Sun L., Lefter L.P., Abe T., Yatsuoka T., Fujimura H., Shibuya E., Kotobuki N., Oshimura M., Sakurada A., Sato M., Kondo T., Matsuno S., Horii A.: Chromosome 12, frequently deleted in human pancreatic cancer, may encode a tumor-suppressor gene that suppresses angiogenesis. Lab Invest., 1339-51, 2004
  70. Lefter L., Scripcaru V., Sunamura M., Furukawa T., Matsuno S., Oshimura M., Drug V., Dragomir C., Horii A.: Screening for functional tumor suppressor activity in pancreatic cancer. Rom J Gastroenterol., 13:195-201, 2004
  71. Yang L., Leung A.C., Ko J.M., Lo P.H., Tang J.C., Srivastava G., Oshimura M.: Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML.: Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. Oncogene, 24:697-705, 2005
  72. Qi DL., Ohhira T., Oshimura M., Kugoh H.: Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT). Biochem Biophys Res Commun. 398:695-701, 2010
  73. Abe S., Tanaka H., Notsu T., Horike S., Fujisaki C., Qi DL., Ohhira T., Gilley D., Oshimura M., Kugoh H.: Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering. Genome Integr. 1:6, 2010
  74. Qi DL., Ohhira T., Fujisaki C., Inoue T., Ohta T., Osaki M., Ohshiro E., Seko T., Aoki S., Oshimura M., Kugoh H.: Identification of PITX1 as a TERT suppressor gene located on human chromosome 5.. Mol Cell Biol. 31:1624-1636, 2011

D: Genetic complementation（遺伝子補正）

  1. Komatsu K., Kodama S., Okumura Y., Koi M., Oshimura M.: Restoration of radiation resistance in ataxia telangiectasia cells by the introduction of normal human chromosome 11. Mutation Res., 235: 59-63, 1990
  2. Ishizaki K., Oshimura M., Sasaki M.S., Nakamura Y., Ikenaga M.: Human chromosome 9 can complement UV-sensitivity of xeroderma pigmentosum group A cells. Mutation Res., 235: 209-215, 1990
  3. Ejima Y., Oshimura M., Sasaki, M.S.: Establishment of a novel immortalized cell line from ataxia telangiectasia fibroblasts and its use for the chromosomal assignment of radiosensitivity gene. Int. J. Rad. Biol., 58: 989-997, 1990
  4. Ejima Y., Oshimura M., Sasaki M.S.: Determination of the chromosomal site for the human radiosensitive ataxia telangiectasia gene by chromosome transfer. Mutation Res., 250: 337-343, 1991
  5. Parshad R., Price F.M., Oshimura M., Barrett J.C., Satoh H., Weissman B.E., Stanbridge E.J., Sanford, K.K.: Complementation of a DNA repair deficiency in six human tumor cell lines by chromosome 11. Hum. Genet., 88: 524-528, 1992
  6. Kodama S., Komatsu K., Okumura Y., Oshimura M.: Suppression of X-ray-induced chromosome aberrations in ataxia telangiectasia cells by introduction of a normal human chromosome 11. Mutation Res., 293: 31-37, 1992
  7. Chen D.J., Park M.S., Campbell E., Oshimura M., Liu P., Zhao Y., White B.F., Siciliano M.J.: Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2. Genomics 13:1088-1094, 1992
  8. Kurimasa A., Ohno K., Oshimura M.: Restoration of the cholesterol metabolism in 3T3 cell lines derived from the sphingomyelinosis mouse (spm/spm) by transfer of a human chromosome 18. Hum. Genet., 92: 157-162, 1993
  9. Ejima Y., Oshimura M., Sasaki M. S.: Use of microcell hybrids for analysis of the 11q23 region and improved localization of the A-T Group A/C genes. Ataxia-Telangiectasia. Cell Biology, 77: 75-85, 1993
  10. Zdzienicka M.Z., Verhaegh G.W.C.T., Jongmans W., Jaspers N.G.J., Oshimura M., James M.R., Lohman, P.H.M.: At-like radiosensitive rodent cell mutants: An alternative approach to the isolation of the AT gene(s). Ataxia-Telangiectasia. Cell Biology, 77: 87-97, 1993
  11. Jongmans W., Wigant J., Oshimura M., James M.R., Lohman P.H.M., Zdzienicka M.Z.: Human chromosome 11 does not complement the defect in AT-like Chinese hamster V79 cell mutants. Human Genet., 92: 259-264, 1993
  12. Kurimasa A., Nagata Y., Shimizu M., Emi M., Nakamura Y., Oshimura M.: A human gene that restores the DNA-repair defect in SCID mice is located on 8p11.1→q11.1. Hum. Genet., 93: 21-26, 1994
  13. 押村光雄：染色体移入による細胞老化遺伝子のマッピング 細胞工学 12:180-184, 1993
  14. Kurimasa A., Ohno K., Oshimura M.: Restoration of the cholesterol metabolism in 3T3 cell lines derived from the sphingomyelinosis mouse (spm/spm) by transfer of a human chromosome 18. Hum. Genet., 92: 157-162, 1993
  15. 押村光雄：染色体導入による不死化細胞の老化誘導 組織培養 19: 450-454, 1993
  16. Ejima Y., Oshimura M., Sasaki M. S.: Use of microcell hybrids for analysis of the 11q23 region and improved localization of the A-T Group A/C genes. Ataxia-Telangiectasia. Cell Biology, 77: 75-85, 1993
  17. Zdzienicka M.Z., Verhaegh G.W.C.T., Jongmans W., Morolli B., Jaspers N.G.J., Oshimura M.: Functional complementation studies with X-ray-sensitive mutants of Chinese hamster cells closely resembling ataxia-telangiectasia cells. Int. J. Radiat. Biol., 66: S189-S195, 1994
  18. Peterson S.R., Kurimasa A., Oshimura M., Dynan W.S., Bradbury E.M., Chen, D.J.: Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA, 92: 3171-3174, 1995
  19. Zenklusen J.C., Oshimura M., Barrett J.C., Conti C.J.: Human chromosome 11 inhibits tumorigenicity of a murine squamous cell carcinoma cell line. Genes, Chromosomes and Cancer, 13: 47-53, 1995
  20. Zdzienicka M.Z., Jongmans W., Oshimura M., Priestley A. Whitemore G.F., Jeggo P.A.: Complementation analysis of the murine SCID cell line. Radiation Res., 143: 238-244, 1995
  21. Verhaegh G.W.C.T., Jongmans W., Jaspers N.G.J., Natarajan A.T., Oshimura M., Lohman P.H.M., Zdzienicka M.: A gene which regulates DNA replication in response to DNA damage is located on human chromosome 4q. Am. J. Hum. Genet., 57: 1095-1103, 1995
  22. Komatsu K., Tauchi H., Matsuura S., Endo S., Kodama S., Smeets D., Weemaes C., Oshimura M.: The gene for Nijmegen breakage syndrome is not located on chromosome 11. Am. J. Hum. Genet., 58: 885-888, 1996
  23. Jongmans W., Verhaegh G.W.C.T., Jasper N.G.J., Demant P., Natarajan A.T., Shiloh Y., Oshimura M., Stanbridge E.J., Athwal R.S., Cuthbert A.P., Newbold R.F., Lohman P.H.M., Zdzienicka M.Z.: The defect in the AT-like hamster cell mutations is complemented by mouse chromosome 9 but any of the human chromosomes. Mutat. Res., 364: 91-102, 1996
  24. Noguchi K., Naito M., Kugoh H., Oshimura M., Mashima T., Fujita N., Yonehara S., Tsuruo T.: Chromosome 22 complements apoptosis in Fas- and TNF-resistant mutant UK110 cells. Oncogene, 13: 39-46, 1996
  25. Matsuura S., Weemaes C., Smeets D., Takami H., Kondo N., Sakamoto S., Yano N., Nakamura A., Tauchi H., Endo S., Oshimura M., Komatsu K.: Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24. Am. J. Hum. Genet., 60: 1487-1494, 1997
  26. Matsuura S., Tauchi H., Nakamura A., Kondo N., SakamotoS., Endo S., Smeets D., Solder B., Belohradsky B.H., Der Kaloustian V.M., Oshimura M., Isomura M., Nakamura Y., Komatsu K.: Positional cloning of the gene for Nijmegen breakage syndrome. Nature Genet., 19: 179-181, 1998
  27. Kodama S., Kashino G., Suzuki K., Takatsuji T., Okumura Y., Oshimura M., Watanabe M., Barrett J.C.: No correction of abnormal phenotypes in Werner Syndrome cells by introduction of a normal human chromosome 81. Cancer Res., 58: 5188-5195, 1998
  28. Errami A., He D.M., Friedl A.A., Overkamp W.J.I., Morolli B., Hendrickson E.A., Eckardt-Schupp F., Oshimura M., Lohman P.H.M., Jackson S.P., Zdzienicka M.Z.: XR-1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucl. Acids Res., 26: 3146-3153, 1998
  29. Cui X., Brenneman M., Meyne J., Oshimura M., Goodwin E.H., Chen, D.J.: The XRCC2 and XRCC3 repair genes are required for chromsoome stability in mammalian cells. Mutat. Res., 434: 75-88, 1999
  30. 栗政明弘，押村光雄　染色体工学を用いた細胞の放射線感受性に関わる遺伝子群の同定　癌の臨床，46:321-329, 2000
  31. Sado K., Ayusawa D., Enomoto A., Suganuma T., Oshimura M., Sato K., Koyama H.: Identification of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells. J. Biol. Chem., 276: 9742-9748, 2001
  32. Horibata K., Iwamoto Y., Kuraoka I., Jaspers NG., Kurimasa A., Oshimura M., Ichihashi M., Tanaka K.: Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome. Proc Natl Acad Sci U S A., 26;101:15410-5, 2004
  33. Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T, Kanazawa S, Koike J, Kikuchi Y, Zhong X, Arita M, Shibuya K, Oshimura M, Hemmi H, Boland CR, Koi M.: Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res., 68:8465-72. 2008
  34. Ariyoshi K., Suzuki K., Goto M., Oshimura M., Ishizaki K., Watanabe M., Kodama S.: Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene. J Radiat Res (Tokyo). 50:253-9. 2009

E: Senescence, telomere and telomerase（細胞老化、テロメア、テロメラーゼ）

  1. Sugawara O., Oshimura M., Koi M., Annab L.A., Barrett J.C.: Induction of cellular senescence in immortalized cells by human chromosome 1. Science, 247: 707-710, 1990
  2. 押村光雄：細胞老化／不死化の染色体レベルでの解析 実験医学 増刊10: 2268-2272, 1992
  3. 大村宏，押村光雄：テロメアと細胞老化・腫瘍化　日本臨床 51: 1899-1906, 1993
  4. Ogata T., Ayusawa D., Nanba M., Takahashi E., Oshimura M., Oishi M.: Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol. and Cell. Biol., 13: 6036-6043, 1993
  5. Sasaki M., Honda T., Yamada H., Wake N., Barrett J.C., Oshimura M.: Evidence for multiple pathways to cellular senescence. Cancer Res., 54: 6090-6093, 1994
  6. Ogata T., Oshimura M., Namba M., Fujii M., Oishi M., Ayusawa D.: Genetic complementation of the immortal phenotype in group D cell lines by introduction of chromosome 7. Jpn. J. Cancer Res., 86: 35-40, 1995
  7. Ohmura H., Tahara H., Suzuki M., Ide T., Shimizu M., Yoshida M.A., Tahara E., Shay J.W., Barrett J.C., Oshimura M.: Restoration of cellular senescence program and repression of telomerase by human chromosome 3. Jpn. J. Cancer Res., 86: 899-904, 1995
  8. Uejima H., Mitsuya K., Kugoh H., Horikawa I., Oshimura, M. : Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line, SiHa. Genes,Chromosomes and Cancer, 14: 120-127, 1995
  9. 鈴木幹生，上島宗之，押村光雄：細胞老化，がん，テロメラーゼ　蛋白質　核酸　酵素，41: 220-227, 1996
  10. 押村光雄，加藤基伸：テロメラーゼ制御遺伝子と癌化　実験医学，14: 683-690, 1996
  11. 押村光雄，田中宏美，久郷裕之：テロメラーゼと細胞老化多経路説　細胞工学　15: 1541-1547, 1996
  12. Oshimura M., Shimizu M., Kugoh H.: Genetic Regulation of telomerase in a multiple pathways model to cellular senescence. Hum. Cell, 9: 301-308, 1996
  13. 久郷裕之，三浦典正，押村光雄：テロメア・セントロメア　臨床染色体診断法　pp.135-143, 1996
  14. 押村光雄，清水素行：細胞工学的手法によるテロメラーゼ抑制　Surgery Frontier, 4: 43-49, 1997
  15. 加藤基伸，田中宏美，押村光雄：テロメラーゼ抑制機構解明への細胞工学的アプローチ　最新医学， 52: 336-342, 1997
  16. Oshimura M., Barrett, J.C.: Multiple pathways to cellular senescence: Role of telomerase repressors. Euro. J. Cancer, 33: 710-715, 1997
  17. 福田弘毅，藤原睦憲，押村光雄：テロメラーゼとがん　The Lung perspectives 5:288-293, 1997
  18. 清水素行，押村光雄：テロメラーゼ活性と癌　癌治療と宿主　9: 355-363, 1997
  19. 清水素行，押村光雄：テロメラーゼ活性と癌　癌治療と宿主　9: 355-363, 1997
  20. 上島宗之，田中宏美，押村光雄：テロメラーゼ発現調節遺伝子　組織培養　23: 16-20, 1997
  21. 大屋敷一馬，押村光雄　癌とテロメア，テロメラーゼ　産科と婦人科　64(1):47-52, 1997
  22. Katoh M., Katoh M., Kameyama M., Kugoh H., Shimizu M., Oshimur M.: A repressor function for telomerase activity in telomerase-negative immortal cells. Mol. Carcinogen., 21:17-25, 1998
  23. Uejima H., Shinohara T., Nakayama Y., Kugoh H., Oshimura M.: Mapping a novel cellular senescence gene to human chromosome 2q37 via irradiation microcell-mediated chromosome transfer. Mol. Carcinogen., 22：34-45，1998
  24. 加藤基伸，加藤みさき，押村光雄：テロメラーゼ発現調節　G.I. Research, 6: 115-122, 1998
  25. 押村光雄：テロメラーゼと癌　日本臨床，56: 1136-1138, 1998
  26. 井上敏昭，加藤基伸，押村光雄：ゲノム工学からのテロメラーゼ・細胞老化制御機構解明へのアプローチ　組織培養工学，24: 224-228, 1998
  27. Horikawa I., Oshimura M., Barrett J.C.: Repression of the telomerase catalytic subunit by a gene on human chromosome 3 that induced cellular senescence. Mol. Carcinogen., 22: 65-72, 1998
  28. Tanaka H., Shimizu M., Horikawa I., Kugoh H., Yokota J., Barrett J.C., Oshimura M.: Evidence for a putative telomerase repressor gene on the 3p14.2-p21.1 region. Genes, Chrom. & Cancer, 23: 123-133, 1998
  29. Nakayama Y., Uejima H., Takahashi T., Yokota J., Oshimura, M.: Loss of heterozygosity at a cellular senescence locus on human chromosome 2 in various types of tumors. Chrom. Sci., 2: 1-4, 1998
  30. 中山祐二，上島宗之，押村光雄　染色体工学を用いた細胞老化遺伝子の探索　組織培養工学　24: 535-539, 1998
  31. 押村光雄，加藤基伸　細胞老化と不死化を制御する遺伝子群　Mol. Medicine, 35: 701-707, 1998
  32. Olson D.J., Oshimura M., Otte A.P., Kumar R.: Ectopic expression of wnt-5a in human renal cell carcinoma cells suppresses in vitro growth and telomerase activity.: Tumour Biol. 1998;19(4):244-52.
  33. Barrett J.C., Horikawa I., Oshimura M., Kugoh H., Shimizu M., Carman T., Afshari C.: Genetic basis for replicative cellular senescence of human cells. Mol. Biol. of Aging Alfred Benson Symposuim, 44: 45-60, 1999
  34. anaka H., Horikawa I., Kugoh H., Shimizu M., Barrett J.C., Oshimura M.: Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer. Mol. Carcinog., 25: 249-255, 1999
  35. Niida H., Shinkai Y., Hande M.P., Matsumoto T., Takehara S., Tachibana M., Oshimura M., Lansdorp P.M., Furuichi Y.: Telomere maintenance in telomerase-deficient mouse embryonic stem cells: Characterization of an amplified telomeric DNA. Mol. Cell. Biol., 20: 4115-4127, 2000
  36. Nishimoto A., Miura N., Horikawa I., Kugoh H., Murakami Y., Hirohashi S., Kawasaki H., Gazdar A.F., Shay J.W., Barrett J.C., Oshimura M.: Functional evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene, 20: 828-835, 2001
  37. Kugoh H., Shigenami K., Funaki K., Barrett J.C., Oshimura M.: Human chromosome 5 carries a putative telomerase repressor gene. Genes, Chrom. & Cancer, 36: 37-47, 2003
  38. Yawata T., Kamino H., Kugoh H., Kato, M., Nomur N., Oishi M., Horikawa I., Barrett J.C., Oshimura M.: Identification of a ≤ 600-kb region on human chromosome 1q42.3 inducing cellular senescence. Oncogene, 22: 281-290, 2003
  39. 押村光雄：テロメア　長寿科学事典　祖父江逸郎監修　医学書院出版　pp.56-57, 2003
  40. Tanaka H., Horikawa I., Barrett J.C., Oshimura M.: Evidence for inactivation of distinct telomerase repressor genes in different types of human cancers. Int J Cancer. 115:653-7, 2005
  41. 押村光雄，中山祐二：老化遺伝子を追う－染色体移入による細胞老化関連遺伝子の探索　　Biophilia Vol.1 No.1, 2005

F: Gene delivery and gene therapy（遺伝子導入と治療）

  1. Kakeda M., Hiratsuka M., Nagata K., Kuroiwa Y., Kakitani M., Katoh M., Oshimura M., Tomizuka K.: Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts. Gene Ther., 12:852-6.2005
  2. Otsuki A., Tahimic CG., Tomimatsu N., Katoh M., Chen DJ., Kurimasa A., Oshimura M.: Construction of a novel expression system on a human artificial chromosome. Biochem Biophys Res Commun., 15:329:1018-25, 2005
  3. Ren X., Katoh M., Hoshiya H., Kurimasa A., Inoue T., Ayabe F.H, Shibata K., Toguchida J., Oshimura M.: A Novel Human Artificial Chromosome Vector Provides Effective Cell Lineage-Specific Transgene Expression in Human Mesenchymal Stem Cells. Stem Cells, 23:1608-16, 2005
  4. 押村光雄：新しい遺伝子治療用ベクターとしてのヒト人工染色体ベクター・遺伝治療はどこまで可能か？　Special Issue02　BIONICS, 30-35 Dec.2005
  5. 押村光雄：新しいベクターとヒト人工染色体・理想的な遺伝子導入ベクターを求めて　Molecular Medcine. Vol.42 No.3 266-269, 2005
  6. 加藤基伸，押村光雄：新しいベクターとヒト人工染色体・ヒト人工染色体ベクターを用いた機能再生医療を目指して　 Molecular Medicine Vol.42 No.3 298-305, 2005
  7. Yamada H., Kunisato A., Kawahara M., Tahimic C.G., Ren X., Ueda H., Nagamune T., Katoh M., Inoue T., Nishikawa M., Oshimura M.: Exogenous gene expression and growth regulation of hematopoietic cells via a novel human artificial chromosome. J Hum Genet., 51:147-50, 2006
  8. Suda T., Katoh M., Hiratsuka M., Takiguchi M., Kazuki Y., Inoue T., Oshimura M.: Heat-regulated production and secretion of insulin from a human artificial chromosome vector. Biochem Biophys Res Commun., 340:1053-61, 2006
  9. 香月康宏，押村光雄：ヒト人工染色体ベクター導入と遺伝子・再生医療への可能性　分子呼吸器病　Vol.10 No.4 34(316)-66(318) 2006
  10. 任　鮮英，押村光雄：遺伝子導入のためのヒト人工染色体ベクタ分子細胞治療　Vol.5 No.3 39(237)-46(244) 2006
  11. 平塚正治，押村光雄：再生医療　11 Vol.5 No.4, 72-77, 2006
  12. Yamaguchi S., Ren X., Katoh M., Miyata K., Fukushima H., Inoue T., Oshimura M.: A new method of microcell-mediated transfer of human Artificial chromosomes using a hemagglutinating virus of Japan envelope. Chromosome Science, 65-73, 2006
  13. Oshimura M., Katoh M.: Transfer human artificial chromosome vectors into stem cells. Reproductive BioMedicine Online. Vol.16 No.1, 57-69, 2008
  14. Kazuki Y., Hoshiya H., Kai Y., Abe S., Takiguchi M., Osaki M.,Kawazoe S., Katoh M., Kanatsu-Shinohara M., Inoue K., Kajitani N., Yoshino N., Shirayoshi Y., Ogura A., Shinohara T., Barrett J.C., Oshimura M.: Correction of a genetic defect in multipotent Germline stem cells using a human artificial chromosome. Gene Therapy, 15:617-24, 2008
  15. Shitara S., Kakeda M., Nagata K., Hiratsuka M., Sano A., Osawa K., Okazaki A., Katoh M., Kazuki Y., Oshimura M.: Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome(HAC) vector. BBRC., 369:807-11, 2008
  16. Yamada H., Li Yanze C., Nishikawa M., Oshimura M., Inoue T.,: Introduction of a CD40L genomic fragment via a human artificial chromosome vector permits cell type-specific gene expression and induces immunoglobulin secretion. J Hum Genet., 53:447-53, 2008
  17. 香月康宏，松岡隆之，押村光雄：ヒト人工染色体を用いたiPS細胞の作製と遺伝子再生医療へ向けて. 再生医療　Vol. 7 No. 3, 2008
  18. Hoshiya H., Kazuki Y., Abe S., Takiguchi M., Kajitani N., Watanabe Y., Yoshino T., Shirayoshi Y., Higaki K., Messina G., Cossu G., Oshimura M.,: A highly stable and non-integrated human artificial chromosome(HAC) containing the 2.4Mb entire human dystrophin gene.Mol Therapy, 17:309-317, 2009
  19. Kazuki Y., Hiratsuka M., Takiguchi M., Osaki M., Kajitani N., Hoshiya H., Hiramatsu K., Yoshino T., Kazuki K., Ishihara C., Takehara S., Higaki K., Nakagawa M., Takahashi K., Yamanaka S., Oshimura M.: Complete genetic correction of ips cells from Duchenne muscular dystrophy. Mol Ther. 386-393,2010
  20. Katoh M., Kazuki Y., Kazuki K., Kajitani N., Takiguchi M., Nakayama Y., Nakamura T., Oshimura M.: Exploitation of the interaction of measles virus fusogenic envelope proteins with the surface receptor CD46 on human cells for microcell- mediated chromosome transfer. BMC Biotechnol. 10:37,2010
  21. Kurosaki H., Hiratsuka M., Imaoka N., Iida Y., Uno N., Kazuki Y., Ishihara C., Yakura Y., Mimuro J., Sakata Y., Takeya H., Oshimura M.: Integration-free and stable expression of FVIII using a human artificial chromosome. Journal of Human Genetics. 56:727-733, 2011
  22. Tedesco F.S., Hoshiya H., D’Antona G., Gerli M. F.M., Messina G., Antonini S., Tonlorenzi R., Benedetti S., Berghella L., Torrente Y., Kazuki H., Bottinelli R., Oshimura M., Cossu G.: Stem Cell-Mediated transfer of a Human Artificial Chromosome Containing the Entire Dystrophin Locus Ameliorates Muscular Dystrophy. Science Transl Med. 3:96ra78, 2011
  23. 香月康宏，押村光雄：iPS細胞とヒト人工染色体ベクターを用いた新たな筋ジストロフィー遺伝子治療に向けて, Medical Science Digest, 2011
  24. 香月康宏，押村光雄：ヒト人工染色体ベクターによる遺伝子細胞治療へ向けて, 日本臨床 2011 p69.
  25. Kazuki Y, Oshimura M.: Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models. Mol Ther. 2011
  26. Yasunaga M, Oumi N, Osaki M, Kazuki Y, Nakanishi T, Oshimura M, Sato K.: Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas. PLoS One 6:e24956, 2011
  27. Hiratsuka M., Uno N., Ueda K., Kurosaki H., Imaoka N., Kazuki K., Ueno E., Akakura Y., Katoh M., Osaki M., Kazuki Y., Nakagawa M., Yamanaka S., Oshimura M.: Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors. PLoS One 6:e25961, 2011
  28. Kazuki Y, Oshimura M.: Toward gene and cell therapy using human artificial chromosome Nihon Rinsho. 2011 69:2142-7.
  29. Tedesco F.S., Gerli M.F., Perani L., Benedetti S., Ungaro F., Cassano M., Antonini S., Tagliafico E., Artusi V., Longa E., Tonlorenzi R., Ragazzi M., Calderazzi G., Hoshiya H., Cappellari O., Mora M., Schoser B., Schneiderat P., Oshimura M., Bottinelli R., Sampaolesi M., Torrente Y., Broccoli V., Cossu G.,: Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy. Sci transl Med. 4:140er89 2012

G: Animal models（動物モデル）

  1. 押村光雄：ヒト染色体導入マウスの誕生　実験医学，16: 511-514, 1998
  2. Inoue T., Shinohara T., Takehara S., Inoue J., Kamino H., Kugoh H., Oshimura M.: Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21. Biochem. Biophys. Res. Commun., 273: 219-224, 2000
  3. Kuroiwa Y., Tomizuka K., Shinohara T., Kazuki Y., Yoshida H., Ohguma A., Yamamoto T., Tanaka S., Oshimura M., Ishida I.: Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts. Nat. Biotechnol., 18:1086-1090, 2000
  4. Shinohara T., Tomizuka K., Takehara S., Yamauchi K., Katoh M., Ohguma A., Ishida I., Oshimura, M.: Stability of transferred human chromosome fragments in cultured cells and in mice. Chromosome Res., 8：713-725, 2000
  5. 黒岩義巳，富塚一磨，押村光雄：ヒトミニ染色体ベクターを用いたメガベ−ス（Mb）サイズの特定ヒト染色体領域のクローニングシステムの開発　実験医学，19:50-52, 2001
  6. Shinohara T., Tomizuka K., Miyabara S., Takehara S., Kazuki Y., Inoue J., Katoh M., Nakane H., Iino A., Ohguma A., Ikegami S., Inokuchi K., Ishida I., Reeves R.H., Oshimura M.: Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down syndrome. Hum. Mol. Genet., 10: 1163-1175, 2001
  7. Ishida I., Tomizuka K., Kuroiwa Y., Yoshida H., Shinohara T., Kazuki Y., Oshimura M.: New perspectives in transgenesis. In: Molecular Farming, eds. Toutant, J.P., Balázs, E., pp.109-119, 2001
  8. Kazuki Y., Shinohara T., Tomizuka K., Katoh M., Ohguma A., Ishida I., Oshimura M.: Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice. J. of Hum. Genet., 46: 600-603, 2001
  9. 石田功，押村光雄：ヒト染色体移入マウス　分子細胞治療，1: 339-343, 2002
  10. Kuroiwa Y., Yoshida H., Ohshima T., Shinohara T., OhgumaA., Kazuki Y., Oshimura M., Ishida I., Tomizuka, K.: The use of chromosome-based vectors for animal transgenesis. Gene Therapy, 9: 708-712,2002
  11. Nishigaki R., Shinohara T., Toda T., Omoi A., Ichinose S., Itoh M., Shirayoshi Y., Kurimasa A., Oshimura M.: An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Biochem. Biophys. Res. Commun., 295: 112-118, 2002
  12. Kadota M., Shirayoshi Y., Oshimura M.: Elevated apoptosis in pre-mature neurons differentiated from mouse ES cells containing a single human chromosome 21. Biochem. Biophys. Res. Commun., 299: 599-605, 2002
  13. Kazuki Y., Schulz T.C., Shinohara T., Kadota M., Nishigaki R., Inoue T., Kimura M., Kai Y., Abe S., Shirayoshi Y., Oshimura M.: A new mouse model for Down syndrome. J. Neural Transm, 67: 1-20, 2003
  14. Wang C.C., Kadota M., Nishigaki R., Kazuki Y., Shirayoshi Y., Rogers M.S., Gojobori T., Ikeo K., Oshimura M.: Molecular hierarchy in neurons diffrentiated from mouse ES cells containing a single human chromosome 21. Biochem. Biophys. Res. Commun., 314: 335-350, 2004
  15. Kazuki Y., Kimura M., Nishigaki R., Kai Y., Abe S., Okita C., Shirayoshi Y., Schulz T.C., Tomizuka K., Hanaoka K., Inoue T., Oshimura M.: Humanchromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice. Biochem Biophys Res Commun., 317:491-9, 2004
  16. 村上芳里，西垣竜一，香月康宏，門田満隆，押村光雄：ダウン症候群モデルマウスから学んだプロテオミクスとエピジェネティクス　生化学　第76巻第10号，2004　　pp.1296-1304
  17. Kadota M., Nishigaki R., Wang CC., Toda T., Shirayoshi Y., Inoue T., Gojobori T., Ikeo K., Rogers MS., Oshimura M.: Proteomicsignatures and aberrations of mouse embryonic stem cells containing a single human chromosome 21 in neuronal differentiation: an in vitro model of Down syndrome. Neuroscience, 129:325-35, 2004
  18. Murakami K., Nishigaki R., Kazuki Y., Kadota M., Oshimura M.: Proteomics and epigenetics learned from Down syndrome model mouse. Seikagaku. 76:1296-304, 2004
  19. Yanagisawa A., Endo C., Okawa K., Shitara S., Kugoh H., Kakitani M., Oshimura M., Tomizuka K.: Generation of chromosome-specific monoclonal antibodies using in vitro differentiated trans-chromosomic (TC) mouse ES cells. Stem Cells., 23:1479-88, 2005
  20. 香月康宏，押村光雄：ヒト染色体導入動物の作製と医学応用　総合臨床　Vol.54 No.1, 48-55, 2005
  21. 西垣竜一，香月康宏，井上敏昭，押村光雄：ヒト21番染色体導入によるダウン症候群モデルマウスのプロテオミクス解析　遺伝子医学312-318, 2005
  22. 西垣竜一，香月康宏，井上敏昭，押村光雄：ダウン症候群モデルマウスのプロテオミクス －ヒト21番染色体トリソミーの意味－　実験医学　Vol.23 No.7, 1065-1071, 2005
  23. 香月康宏，押村光雄：ダウン症候群モデルマウスの遺伝子発現解析－21番染色体トリソミーの意味－　特集　脳の遺伝子—どこでどのように働いているのか　生体の科学　第56巻　第4号　327-335, 2005
  24. Mizuta E., Furuichi H., Kazuki Y., Miake J., Yano S., Bahrudin U., Yamamoto Y., Igawa O., Shigemasa C., Hidaka K., Morisaki T., Kurata Y., Ninomiya H., Kitakaze M., Shirayoshi Y., Oshimura M., Hisatome I.: Delayed onset of beating and decreased expression of T-type Ca(2+) channel in mouse ES cell-derived cardiocytes carrying human chromosome 21. Biochem Biophys Res Commun., 351:126-132, 2006
  25. 香月康宏，押村光雄：特集実験動物を用いた再生医学研究；器官形成と幹細胞・幹細胞とヒト人工染色体ベクターの出会い　アニテックス　Vol.19 No.1, 2007
  26. 香月康宏，押村光雄：ヒト染色体導入ヒト型マウス/生物機能モデルと新しいリソース・リサーチツール（株）エル・アイ・シー，p432-435,　2011
  27. 香月康宏，押村光雄：染色体工学技術による医薬品開発のためのヒト化モデル動物の開発, 毒性質問箱 2011
  28. Nakanishi T., Kokubun K., Oda H., Aoki M., Soma A., Taniguchi M., Kazuki Y., Oshimura M., Sato K.: Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice. Bone. 51:369-375, 2012

H: Imprinting（遺伝子刷り込み）

  1. 三ツ矢幸造，押村光雄：インプリント遺伝子の発現パターンと検索法の開発　組織培養 21: 122-126, 1995
  2. Meguro M., Mitsuya K., Sui H., Shigenami K., Kugoh H., Nakao M., Oshimura M.: Evidence for paternal expression of the human GABAA receptor subunit genes, using microcell-mediated chromosome transfer. Hum. Mol. Genet., 6: 2127-2133, 1997
  3. Mitsuya K,. Meguro M., Sui H., Schulz T.C., Kugoh H., Hamada H., Oshimura, M.: Developmental reprogramming of the human H19 gene in mouse embryonic cells does not erase the primary parental imprint. Genes to Cells, 3：245-255，1998
  4. 三ツ矢幸造，目黒牧子，押村光雄：ヒト染色体移入マウス細胞を用いたゲノム刷り込みの解析　蛋白質　核酸　酵素，43:573-582, 1998
  5. Kugoh H., Mitsuya K., Meguro M., Shigenami K., Schulz T.C., Oshimura M.: Mouse A9 cells containing single human chromosomes for analysis of genomic imprinting. DNA Res., 6: 165-172, 1999
  6. Mitsuya K., Meguro M., Lee M.P., Katoh M., Schulz T.C., Kugoh H., Yoshida M.A., Niikawa N., Feinberg A.P., Oshimura M.: LIT1, an imprinted antisense RNA in the human KvLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids. Hum. Mol. Genet., 8: 1209-1217, 1999
  7. Lee M.P., DeBaun M.R., Mitsuya K., Galonek H.L., Brandenburg S., Oshimura M., Feinberg A.P.: Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of IGF2 imprinting. Proc. Natl. Acad. Sci., USA, 96:5203-5208, 1999
  8. Arima T., Drewell R.A., Oshimura M., Wake N., Surani M.A.: A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC. Genomics, 67: 248-255, 2000
  9. Horike S., Mitsuya K., Meguro M., Kotobuki N., Kashiwagi A., Notsu T., Schulz T.C., Shirayoshi Y., Oshimura M.: Targeted disruption of the human LIT1 locus defines a putative imprinting control element playing an essential role in beckwith-wiedemann syndrome. Hum. Mol. Genet., 9: 2075-83, 2000
  10. Meguro M., Mitsuya K., Nomura N., Kohda M., Kashiwagi A., Nishigaki R., Yoshioka H., Nakao M., Oishi M., Oshimura, M.: Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resmblin small nucleolar RNA genes. Hum. Mol. Genet., 10:383-394, 2001
  11. Meguro M., Kashiwagi A., Mitsuya K., Nakao M., Kondo I., Saitoh S., Oshimura M.: A novel maternally expressed gene, ATP10C, encoding a putative aminophospholipid translocase associated with Angelman syndrome. Nat. Genet., 28: 19-20, 2001
  12. Maegawa S., Yoshioka H., Itaba N., Kubota N., NishiharaS., Shirayoshi Y., Nanba E., Oshimura M.: Epigenetic silencing of PEG3 gene expression in human glioma cell lines. Mol. Carcinog., 31: 1-9, 2001
  13. Arima T., Drewell R.A., Arney K.L., Inoue J., Makita Y., Hata A., Oshimura M., Wake N., Surani M.A.: A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. Hum. Mol. Genet., 10: 1475-1483, 2001
  14. Mizuno Y., Sotomaru Y., Katsuzawa Y., Kono T., Meguro M., Oshimura M., Kawai J., Tomaru Y. Kiyosawa H., Nikaido I., Amanuma H., Hayashizaki Y., Okazaki Y.: Asb4, Ata3, and Dcn are novel imprinting genes identified by high-throughput screening using RIKEN cDNA microarray. Biochem. Biophys. Res. Commun., 290: 1499-1505,2002
  15. Nakabayashi K., Fernandez B.A., Teshima I., Shuman C., Proud V.K., Curry C.J., Chitayat D., Grebe T., Ming J., Oshimura M., Meguro M., Mitsuya K., Deb-Rinker P., Herbrick J.A., Weksberg R., Scherer S.W.: Molecular genetic studies of human chromosome 7 in Russell Silver syndrome. Genomics, 79: 186-196, 2002
  16. 吉岡広陽，押村光雄：ゲノムインプリンティングの異常と疾患　Mol. Medicine, 39:802-808, 2002
  17. 目黒牧子，押村光雄：ゲノム刷り込みと疾患　実験医学，20: 1692-1697, 2002
  18. 春田雅之，押村光雄：染色体工学を用いたヒトの刷り込み現象に関する研究　医学のあゆみ　202: 237-241, 2002
  19. 須田哲司，押村光雄：癌と刷り込み異常　Mol. Medicine, 39: 146-154, 2002
  20. 押村光雄：細胞の個性を決めるエピジェネティクス　実験医学　20: 2184-2187, 2002
  21. 香月康宏，吉岡広陽，春田雅之，押村光雄：発生・分化のキーメカニズムとしてのゲノムインプリンティング　実験医学　: 2219-2224, 2002
  22. Feinberg A.P., Oshimura M., Barrett J.C.: Epigenetic mechanisms in human disease. Cancer Res., 62: 6784-6787, 2002
  23. Jouvenot Y., Ginjala V., Zhang L., Liu P-Q., Oshimura M., Feinberg A.P., Wolffe A.P., Ohlsson R., Gregory P.D.: Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors. Gene Therapy, 10: 513-522, 2003
  24. 大槻明広，押村光雄：ゲノム刷り込みの異常と疾患　現代医療35: 1013-1018, 2003
  25. Kashiwagi A., Meguro M., Hoshiya H., Haruta M., Ishino F., Shibahara T., Oshimura M.: Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb. J. Hum. Genet., 48: 194-198, 2003
  26. Hoshiya H., Meguro M., Kashiwagi A., Okita C., Oshimura M.: Calcr, a brain-specific imprinted mouse calcitonin receptor gene in the imprinted cluster of proximal region of chromosome 6. J. Hum. Genet., 48: 208-211, 2003
  27. Yu Y., Fujii S., Yuan J., Luo R.Z., Wang L., Bao J., Kaodta M., Oshimura M., Dent S.R., Issa J.P., Bast R.C.Jr.: Epigenetc regulation of ARHI in breast and ovarian cancer cells. Ann. N.Y. Acad. Sci., 983: 268-277, 2003
  28. Nikaido I., Saito C., Mizuno Y., Meguro M., Bono H., Kadomura M., Kono T., Morris G.A., Lyons P.A., Oshimura M., RIKEN GER Group and GSL Members, Hayashizaki Y., Okazaki Y.: Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profiling. Genome Res., 13: 1402-1408, 2003
  29. Okita C., Meguro M., Hoshiya H., Haruta M., Sakamoto Y., Oshimura M.: A new imprinted cluster on the human chromosome 7q21-q31, identified by human-mouse monochromosomal hybrids. Genomics, 81: 556-559, 2003
  30. Fujii S., Luo R.Z., Yuan J., Kadota M., Oshimura M., Dent S.R., Kondo Y., Issa J-P.J., Bast R.C.Jr., Yu Y.: Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum. Mol. Genet., 12: 1791-1800, 2003
  31. Yuan J., Luo R.Z., Fujii S., Wang L., Hu W., Andreeff M., Pan Y., Kadota M., Oshimura M., Sahin A.A., Issa J-P., Bast R.C.Jr., Yu Y.: Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancer. Cancer Res., 63: 4174-4180, 2003
  32. 押村光雄：生命現象とエピジェネティクス　実験医学, 21:1495-1498, 2003
  33. 目黒牧子，押村光雄：ゲノム刷り込み異常と疾患　実験医学, 21: 1552-1557, 2003
  34. 押村光雄，今井浩三，牛島俊和：エピジェネティクスの診断への応用，治療への応用の可能性　現代医学　35: 908-924, 2003
  35. Suda T., Katoh M., Hiratsuka M., Fujiwara M., Irizawa Y., Oshimura M.: Use of real-time RT-PCR for the detection of allelic expression of an imprinted gene. Intl. J. Mol. Med., 12：243-246, 2003
  36. Higashimoto K., Urano T., Sugiura K., Yatsuki H., Joh K., Zhao W., Iwakawa M., Ohashi H., Oshimura M., Niikawa N., Mukai, T., Soejima H.: Loss of CpG methylation is strongly correlated with loss of histon H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome. Am. J. Hum. Genet., 73: 948-956, 2003
  37. 坂谷貴司，押村光雄：がんとエピジェネティクス　58：2125-2133, 2003
  38. Yamada T., Mitsuya K., Kayashima T., Yamasaki K., Ohta T., Yoshiura K-I., Matsumoto N., Yamada H., Minakami H., Oshimura M., Niikawa M., Kishino T.: Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32. Genomics, 83: 402-412, 2004
  39. Hirota T., Ieiri I., Takane H., Maegawa S., Hosokawa M., Kobayashi K., Chiba K., Nanba E., Oshimura M., Sato T., Higuchi S., Otsubo K.: Allelic expression imbalance of the human CYP3A4 gene and individualphenotypic status.Hum Mol Genet., 13:2959-69,2004
  40. Soejima H., Nakagawachi T., Zhao W., Higashimoto K., Urano T., Matsukura S., Kitajima Y., Takeuchi M., Nakayama M., Oshimura M., Miyazaki K., Joh K., Mukai T.: Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer. Oncogene, 23:4380-8, 2004
  41. Maegawa S., Itaba N., Otsuka S., Kamitani H., Watanabe T., Tahimic CG., Nanba E., Oshimura M.: Coordinate downregulation of a novel imprinted transcript ITUP1 with PEG3 in glioma cell lines. DNA Res., 29;11:37-49, 2004
  42. Fukagawa T., Nogami M., Yoshikawa M., Ikeno M., Okazaki T., Takami Y., Nakayama T., Oshimura M.: Dicer is essential for formation of the heterochromatin structure in vertebrate cells. Nat Cell Biol. 6:784-91.,2004
  43. Nakabayashi K., Makino S., Minagawa S., Smith AC., Bamforth JS., Stanier P., Preece M., Parker-Katiraee L., Paton T., Oshimura M., Mill P., Yoshikawa Y., Hui C.C., Monk D., Moore G.E., Scherer S.W.: Genomic imprinting of PPP1R9A encoding neurabin I in skeletal muscle and extra-embryonic tissues. J Med Genet. 41:601-608, 2004
  44. Kimura M.I., Kazuki Y., Kashiwagi A., Kai Y., Abe S., Barbieri O., Levi G., Oshimura M.: Related Articles, Links Dlx5, the mouse homologue of The human-imprinted DLX5 gene, is biallelically expressed in the mouse brain. J Hum Genet., 49:273-7., 2004
  45. 三ツ矢幸造，押村光雄：ゲノムインプリンティングの解析　実験医学別冊クロマチン染色体実験プロトコール 68-7, 2004
  46. 木村元思，押村光雄：染色体の細胞への導入技術　実験医学別冊クロマチン染色体実験プロトコール 194-202, 2004
  47. 坂元裕樹，春田雅之，押村光雄：染色体工学を用いたヒトのエピジェネティクス　　 解析，エピジェネティクス，シュプリンガー・フェアラーク東京（株）pp.221-228, 2004
  48. 押村光雄，三ツ矢幸造：生物にとって必須なエピジェネティクス　注目のエピジェネティクスがわかる　12-20, 2004
  49. 三ツ矢幸造，押村光雄：エピジェネティクスな不均等生と生命現象　注目のエピジェネティクスがわかる　53-62, 2004
  50. 坂谷貴司，三ツ矢幸造，押村光雄：個体差に関わるエピジェネティクス　注目のエピジェネティクスがわかる　103-110, 2004
  51. 井上敏昭，押村光雄：ゲノム不安定性に関わるエピジェネティクス　注目のエピジェネティクスがわかる　117-120, 2004
  52. Yu W., Ginjala V., Pant V., Chernukhin I., Whitehead J., Docquier F., Farrar D., Tavoosidana G., Mukhopadhyay R., Kanduri C., Oshimura M., Feinberg A.P., Lobanenkov V., Klenova E., Ohlsson R.: Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation. Nat Genet.,36:1105-10, 2004
  53. Nakanishi H., Suda T., Katoh M., Watanabe A., Igishi T., Kodani M., Matsumoto S., Nakamoto M., Shigeoka Y., Okabe T., Oshimura M., Shimizu E.: Loss of imprinting of PEG1/MEST in lungcancer cell lines. Oncol Rep., 12:1273-8. 2004
  54. Haruta M., Meguro M., Sakamoto YK., Hoshiya H., Kashiwagi A., Kaneko Y., Mitsuya K., Oshimura M.: Narrowed abrogation of the Angelman syndrome critical interval on human chromosome 15 does not interfere with epigenotype maintenance in somatic cells. J Hum Genet., 50:124-32. 2005
  55. Arima T., Kamikihara T., Hayashida T., Kato K., Inoue T., Shirayoshi Y., Oshimura M., Soejima H., Mukai T., Wake N.: ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.Nucleic Acids Res., 33:2650-60, 2005
  56. Ishihara K., Oshimura M., Nakao M.: CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol. Cell, 23:733-42, 2006
  57. Francks C., Maegawa S., Lauren J., Abrahams B.S., Velayos-Baeza A., Medland S.E., Colella S., Groszer M., McAuley E.Z., Caffrey T.M., Timmusk T., Pruunsild P., Koppel I., Lind P.A., Matsumoto-Itaba N., Nicod J., Xiong L., Joober R., Enard W., Krinsky B., Nanba E., Richardson A.J., Riley B.P., Martin N.G., Strittmatter S.M., Moller H.J., Rujescu D., St. Clair D., Muglia P., Roos J.L., Fisher S.E., Wade-Martins R., Rouleau G.A., Stein J.F., Karayiorgou M., Geschwind D.H., Ragoussis J., Kendler K.S., Airaksinen M.S., Oshimura M., Delisi L.E., Monaco A.P.: LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry, 12:1129-39, 2007
  58. Nguyen P., Cui H., Bisht KS., Sun L., Patel K., Lee RS., Kugoh H., Oshimura M., Feinberg AP., Gius D.CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region. Cancer Res., 68:5546-51, 2008
  59. Yotova IY, Vlatkovic IM, Pauler FM, Warczok KE, Ambros PF, Oshimura M, Theussl HC, Gessler M, Wagner EF, Barlow DP.: Identification of the human homolog of the imprinted mouse Air non-coding RNA. Genomics, 92:464-73. 2008
  60. Meguro-Horike M, Yasui DH, Powell W, Schroeder DI, Oshimura M, Lasalle JM, Horike S.: Neuron-specific impairment of inter-chromosomal pairing and transcription in a novel model of human 15q-duplication syndrome. Hum Mol Genet. 20:3798-3810, 2011
  61. Itoh M., Tahimic C.G., Ide S., Otsuki A., Sasaoka T., Noguchi S., Oshimura M., Goto Y., Kurimasa A.: J Biol Chem. 287:13859-13867, 2012

I: DNA marker and mapping（DNAマーカーとマッピング）

  1. Yamakawa K., Takahashi E., Saito H., Sato T., Oshimura M., Hori, T. and Nakamura, Y.: Isolation and mapping of 75 new DNA markers on human chromosome 3. Genomics, 9: 536-543, 1991
  2. Seya T., Okada M., Hara T., Matsumoto M., Miyagawa S., Oshimura M.: Human complement regulatory proteins expressed on mouse A9 cells containing a human chromosome 1. Immunology, 74: 719-724, 1991
  3. Hosoya M., Kimura C., Ogi K., Ohkubo S., Miyamoto Y., Kugoh H., Shimizu M., Onda H., Oshimura M., Arimura A., Fujino M.: Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. Biochem. Biophys. Acta., 1129: 199-206, 1992
  4. Sugino H., Oshimura M., Matsubara K.: Banding profiles of LTR of human endogenous retrovirus HERV-A in 24 chromosomes in somatic cell hybrids. Genomics, 13: 461-464, 1992
  5. Iizuka M., Mashiyama S., Oshimura M., Sekiya T., Hayashi, K.: Cloning and polymerase chain reaction-single-strand conformation polymorphism analysis of anonymous alu repeats on chromosome 11. Genomics, 12: 139-146, 1992
  6. Saito S., Okui K., Tokino T., Oshimura M., Nakamura Y.: Isolation and mapping of 68 RFLP markers on human chromosome 6. Am. J. Hum. Genet., 50: 65-70, 1992
  7. Tamari M., Hamaguchi M., Shimizu M., Oshimura M., Takayama H., Kohno T., Yamaguchi N., Sugimura T., Terada M., Yokota J.: Ordering of human chromosome 3p markers by radiation hybrid mapping. Genomics, 13: 705-712, 1992
  8. Jinno Y., Harada N., Yoshiura K., Ohta T., Tohma T., Hirota T. Tsukamoto K., Deng H., Oshimura M., Niikawa N.: A simple and efficient amplification method of DNA with unknown sequences and its application to microdissection/ microcloning. J. Biochem., 112: 75-80, 1992
  9. Emi M., Takahashi E., Koyama K., Okui K., Oshimura M., Nakamura Y.: Isolation and mapping of 88 new RFLP markers on human chromosome 8. Genomics, 13: 1261-1266, 1992
  10. Yamakawa K., Takahashi E., Saito H., Sato T., Oshimura M., Hori T., Nakamura Y.: Isolation and mapping of 75 new DNA markers on human chromosome 3. Genomics, 9: 536-543, 1991
  11. 押村光雄，栗政明弘，清水素行：微小核融合細胞のゲノム解析への利用 蛋白質　核酸　酵素 38: 563-572, 1993
  12. Yamamoto K., Seto M., Akao Y., Iida S., Nakazawa S., Oshimura M., Takahashi M., Takahashi T., Ueda R.: Gene rearrangement and truncated mRNA in cell with 11q23 translocation. Oncogene, 8: 479-485, 1993
  13. Kohno T., Takayama H., Hamaguchi M., Takano H., Yamaguchi N., Tsuda H., Hirohashi S., Vissing H., Shimizu M., Oshimura M., Yokota J.: Deletion mapping of chromosome 3p in human uterine cervical cancer. Oncogene, 8: 1825-1832, 1993
  14. Ohe N., Yamasaki Y., Sogawa K., Inazawa J., Ariyama T., Oshimura M., Fujii -K.Y.: Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein. Somatic cell and Mol. Genet., 19: 499-503, 1993
  15. Fujiwara Y., Ohata H., Emi M., Okui K., Koyama K., Tsuchiya E., Nakajima T., Moden M., Mori T., Kurimasa A., Oshimura M., Nakamura Y.: A3-Mb physical map of the chromosome region 8p21.3-p22, including a 600-kb region commonly deleted in Human Hepatocellular Carcinoma, colorectal cancer, and Non-small Cell Lung Cancer. Genes, Chromosomes and Cancer, 10: 7-14, 1994
  16. Ema M., Matsushita N., Sogawa K., Ariyama T., Inazawa J., Nemoto T., Ota M., Oshimura M., Fujii-Kuriyama Y.: Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21. J. Biochem., 116: 845-851, 1994
  17. Horikawa I., Tanaka H., Yuasa Y., Suzuki M., Oshimura M.: Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability. Biochem. Biophys. Res. Commun., 208: 999-1007, 1995
  18. Kugoh H., Nakagawa Y., Mitsuya K., Mita T., Suzuki M., Suzuki N., Uejima H., Yuasa Y. Oshimura M.: Isolation and mapping of 186 new DNA markers on human chromosome 1. Genomics, 27: 207-210, 1995
  19. Urimasa A., Suzuki N., Kumano S., Li H., Wells D., Wagner M. J., Chen F., Chen D. J., Oshimura M.: Construction of 110 cosmid markers and a 4.5 Mb YAC contig on human chromosome 8p12-q11. Genomics, 28: 147-153, 1995
  20. Katoh M., Nakagawa Y., Yawata T., Kumano S., Kobayashi E., Kurimasa A., Kugoh H., Oshimura M.: Cosmids and transcribed sequences from chromosome 11q23. Jpn. J. Hum. Genet., 40: 307-317, 1995
  21. Kitagawa K., Hatada I., Wang X., Yamaoka T., Nojima H., Inazawa J., Abe T., Mitsuya K., Oshimura M., Murata A., Monden M., Mukai T.: Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1. Genomics, 30: 257-263, 1995
  22. Kobayashi D., Ieiri I., Hirota T., Takane H., Maegawa S., Kigawa J., Suzuki H., Nanba E., Oshimura M., Terakawa N., Otsubo K., Mine K., Sugiyama Y.: Functional assessment of abcg2 (bcrp) gene polymorphisms to proteinExpressi onin human placenta. Drug Metabolisum and Disposition, 33:94-101, 2004
  23. Nguyen G., Bukanov N., Oshimura M., Smith CL.: Cloneless genomic DNA analysis: an efficient and simple methods for de novo genomic sequencing projects and gap filling. Biomol Eng., 21:135-44.2005
  24. Spence J.M., Fournier R.E., Oshimura M., Regnier V., Farr C.J.: Topoisomerase II cleavage activity within the human D11Z1 and DXZ1 alpha-satellite arrays. Chromosome Res., 13:637-48, 2005

J: Others（その他）

  1. 長田愉以子，押村光雄：遺伝性癌と非遺伝性癌の相違 臨床科学 28: 1311-1315, 1992
  2. Kohno T., Sekine T., Tobisu K., Oshimura M., Yokota J.: Chromosome 3p deletion in a cell carcinoma cell line established from a patient with von Hippel-Lindau desease Jpn. J. Clin. Oncol., 23: 226-231, 1993
  3. Suzuki N., Sugawara M., Sugimoto M., Oshimura M., Furuichi Y.: Gene expression of transferred human chromosome 8 in mouse cell lines. Biochem. Biophys. Res. Commun., 230: 315-319, 1997
  4. Mukaida N., Kodama S., Suzuki K., Oshimura M., Watanabe M.: Transmission of genomic instability from a single irradiated human chromosome to the progeny of unirradiated cells, Radiat Res., 167:675-81, 2007
  5. Kai Y., Wang CC., Kishigami S., Kazuki Y., Abe S., Takiguchi M., Shirayoshi Y., Inoue T., Ito H., Wakayama T., Oshimura M.: Enhanced apoptosis during early neuronal differentiation in mouse ES cells with autosomal imbalance. Cell Res., 19:247-58, 2008
  6. Kinoshita Y, Kamitani H, Mamun MH, Wasita B, Kazuki Y, Hiratsuka M, Oshimura M, Watanabe T.: A gene delivery system with a human artificial chromosome vector based on migration of mesenchymal stem cells towards human glioblastoma HTB14 cells. Neurol Res. 32:429-37, 2009
  7. Takahashi Y, Tsuji S, Kazuki Y, Noguchi M, Arifuku I, Umebayashi Y, Nakanishi T, Oshimura M, Sato K.: Development of evaluation system for bioactive substances using human artificial chromosome-mediated osteocalcin gene expression. J Biochem. 148:29-34,2010
  8. Wang CC, Kazuki Y, Oshimura M, Ikeo K, Gojobori T.: Gene dosage ibalance of human chromosome 21 in mouse embryonic stem cells differentiating to neurons. Gene. 481:93-101, 2011
  9. Nawata H., Kashino G., Tano K., Daino K., Shimada Y., Kugoh H., Oshimura M., Watanabe M.: Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes. Plos One. 6:e25319, 2011