鳥取大学における染色体医工学研究の歩み

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25. Kazuki Y, Oshimura M.: Human Artifi cial Chromosomes for Gene Delivery and the Development of Animal Models. Mol Ther. 201126. Yasunaga M, Oumi N, Osaki M, Kazuki Y, Nakanishi T, Oshimura M, Sato K.: Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas. PLoS One 6:e24956, 201127. Hiratsuka M., Uno N., Ueda K., Kurosaki H., Imaoka N., Kazuki K., Ueno E., Akakura Y., Katoh M., Osaki M., Kazuki Y., Nakagawa M., Yamanaka S., Oshimura M.: Integration-Free iPS Cells Engineered Using Human Artifi cial Chromosome Vectors. PLoS One 6:e25961, 201128. Kazuki Y, Oshimura M.: Toward gene and cell therapy using human artificial chromosome Nihon Rinsho. 2011 69:2142-7.29. Tedesco F.S., Gerli M.F., Perani L., Benedetti S., Ungaro F., Cassano M., Antonini S., Tagliafico E., Artusi V., Longa E., Tonlorenzi R., Ragazzi M., Calderazzi G., Hoshiya H., Cappellari O., Mora M., Schoser B., Schneiderat P., Oshimura M., Bottinelli R., Sampaolesi M., Torrente Y., Broccoli V., Cossu G.,: Transplantation of Genetically Corrected Human iPSC-Derived Progenitors in Mice with Limb-Girdle Muscular Dystrophy. Sci transl Med. 4:140er89 2012G: Animal models(動物モデル)1. 押村光雄:ヒト染色体導入マウスの誕生 実験医学,16: 511-514, 19982. Inoue T., Shinohara T., Takehara S., Inoue J., Kamino H., Kugoh H., Oshimura M.: Specifi c impairment of cardiogenesis in mouse ES cells containing a human chromosome 21. Biochem. Biophys. Res. Commun., 273: 219-224, 20003. Kuroiwa Y., Tomizuka K., Shinohara T., Kazuki Y., Yoshida H., Ohguma A., Yamamoto T., Tanaka S., Oshimura M., Ishida I.: Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts. Nat. Biotechnol., 18:1086-1090, 20004. Shinohara T., Tomizuka K., Takehara S., Yamauchi K., Katoh M., Ohguma A., Ishida I., Oshimura, M.: Stability of transferred human chromosome fragments in cultured cells and in mice. Chromosome Res., 8:713-725, 20005. 黒岩義巳,富塚一磨,押村光雄:ヒトミニ染色体ベクターを用いたメガベ-ス(Mb)サイズの特定ヒト染色体領域のクローニングシステムの開発 実験医学,19:50-52, 20016. Shinohara T., Tomizuka K., Miyabara S., Takehara S., Kazuki Y., Inoue J., Katoh M., Nakane H., Iino A., Ohguma A., Ikegami S., Inokuchi K., Ishida I., Reeves R.H., Oshimura M.: Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down syndrome. Hum. Mol. Genet., 10: 1163-1175, 20017. Ishida I., Tomizuka K., Kuroiwa Y., Yoshida H., Shinohara T., Kazuki Y., Oshimura M.: New perspectives in transgenesis. In: Molecular Farming, eds. Toutant, J.P., Balázs, E., pp.109-119, 20018. Kazuki Y., Shinohara T., Tomizuka K., Katoh M., Ohguma A., Ishida I., Oshimura M.: Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice. J. of Hum. Genet., 46: 600-603, 20019. 石田功,押村光雄:ヒト染色体移入マウス 分子細胞治療,1: 339-343, 200210. Kuroiwa Y., Yoshida H., Ohshima T., Shinohara T., OhgumaA., Kazuki Y., Oshimura M., Ishida I., Tomizuka, K.: The use of chromosome-based vectors for animal transgenesis. Gene Therapy, 9: 708-712,200211. Nishigaki R., Shinohara T., Toda T., Omoi A., Ichinose S., Itoh M., Shirayoshi Y., Kurimasa A., Oshimura M.: An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Biochem. Biophys. Res. Commun., 295: 112-118, 200212. Kadota M., Shirayoshi Y., Oshimura M.: Elevated apoptosis in pre-mature neurons diff erentiated from mouse ES cells containing a single human chromosome 21. Biochem. Biophys. Res. Commun., 299: 599-161

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