鳥取大学における染色体医工学研究の歩み

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199829. Nakayama Y., Uejima H., Takahashi T., Yokota J., Oshimura, M.: Loss of heterozygosity at a cellular senescence locus on human chromosome 2 in various types of tumors. Chrom. Sci., 2: 1-4, 199830. 中山祐二,上島宗之,押村光雄 染色体工学を用いた細胞老化遺伝子の探索 組織培養工学 24: 535-539, 199831. 押村光雄,加藤基伸 細胞老化と不死化を制御する遺伝子群 Mol. Medicine, 35: 701-707, 199832. Olson D.J., Oshimura M., Otte A.P., Kumar R.: Ectopic expression of wnt-5a in human renal cell carcinoma cells suppresses in vitro growth and telomerase activity.: Tumour Biol. 1998;19(4):244-52.33. Barrett J.C., Horikawa I., Oshimura M., Kugoh H., Shimizu M., Carman T., Afshari C.: Genetic basis for replicative cellular senescence of human cells. Mol. Biol. of Aging Alfred Benson Symposuim, 44: 45-60, 199934. Tanaka H., Horikawa I., Kugoh H., Shimizu M., Barrett J.C., Oshimura M.: Telomerase-independent senescence of human immortal cells induced by microcell-mediated chromosome transfer. Mol. Carcinog., 25: 249-255, 199935. Niida H., Shinkai Y., Hande M.P., Matsumoto T., Takehara S., Tachibana M., Oshimura M., Lansdorp P.M., Furuichi Y.: Telomere maintenance in telomerase-deficient mouse embryonic stem cells: Characterization of an amplifi ed telomeric DNA. Mol. Cell. Biol., 20: 4115-4127, 200036. Nishimoto A., Miura N., Horikawa I., Kugoh H., Murakami Y., Hirohashi S., Kawasaki H., Gazdar A.F., Shay J.W., Barrett J.C., Oshimura M.: Functional evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene, 20: 828-835, 200137. Kugoh H., Shigenami K., Funaki K., Barrett J.C., Oshimura M.: Human chromosome 5 carries a putative telomerase repressor gene. Genes, Chrom. & Cancer, 36: 37-47, 200338. Yawata T., Kamino H., Kugoh H., Kato, M., Nomur N., Oishi M., Horikawa I., Barrett J.C., Oshimura M.: Identifi cation of a ≤ 600-kb region on human chromosome 1q42.3 inducing cellular senescence. Oncogene, 22: 281-290, 200339. 押村光雄:テロメア 長寿科学事典 祖父江逸郎監修 医学書院出版 pp.56-57, 200340. Tanaka H., Horikawa I., Barrett J.C., Oshimura M.: Evidence for inactivation of distinct telomerase repressor genes in diff erent types of human cancers. Int J Cancer. 115:653-7, 2005 41. 押村光雄,中山祐二:老化遺伝子を追う-染色体移入による細胞老化関連遺伝子の探索 Biophilia Vol.1 No.1, 2005F: Gene delivery and gene therapy(遺伝子導入と治療)1. Kakeda M., Hiratsuka M., Nagata K., Kuroiwa Y., Kakitani M., Katoh M., Oshimura M., Tomizuka K.: Human artifi cial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fi broblasts. Gene Ther., 12:852-6.2005 2. Otsuki A., Tahimic CG., Tomimatsu N., Katoh M., Chen DJ., Kurimasa A., Oshimura M.: Construction of a novel expression system on a human artificial chromosome. Biochem Biophys Res Commun., 15:329:1018-25, 20053. Ren X., Katoh M., Hoshiya H., Kurimasa A., Inoue T., Ayabe F.H, Shibata K., Toguchida J., Oshimura M.: A Novel Human Artifi cial Chromosome Vector Provides Eff ective Cell Lineage-Specifi c Transgene Expression in Human Mesenchymal Stem Cells. Stem Cells, 23:1608-16, 2005 4. 押村光雄:新しい遺伝子治療用ベクターとしてのヒト人工染色体ベクター・遺伝治療はどこまで可能か? Special Issue02 BIONICS, 30-35 Dec.20055. 押村光雄:新しいベクターとヒト人工染色体・理想的な遺伝子導入ベクターを求めて Molecular Medcine. Vol.42 No.3 266-269, 20056. 加藤基伸,押村光雄:新しいベクターとヒト人工染色体・ヒト人工染色体ベクターを用いた機能再生医療を目指して Molecular Medicine Vol.42 No.3 298-305, 2005159

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