鳥取大学における染色体医工学研究の歩み

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Complementation analysis of the murine SCID cell line. Radiation Res., 143: 238-244, 199521. Verhaegh G.W.C.T., Jongmans W., Jaspers N.G.J., Natarajan A.T., Oshimura M., Lohman P.H.M., Zdzienicka M.: A gene which regulates DNA replication in response to DNA damage is located on human chromosome 4q. Am. J. Hum. Genet., 57: 1095-1103, 199522. Komatsu K., Tauchi H., Matsuura S., Endo S., Kodama S., Smeets D., Weemaes C., Oshimura M.: The gene for Nijmegen breakage syndrome is not located on chromosome 11. Am. J. Hum. Genet., 58: 885-888, 199623. Jongmans W., Verhaegh G.W.C.T., Jasper N.G.J., Demant P., Natarajan A.T., Shiloh Y., Oshimura M., Stanbridge E.J., Athwal R.S., Cuthbert A.P., Newbold R.F., Lohman P.H.M., Zdzienicka M.Z.: The defect in the AT-like hamster cell mutations is complemented by mouse chromosome 9 but any of the human chromosomes. Mutat. Res., 364: 91-102, 199624. Noguchi K., Naito M., Kugoh H., Oshimura M., Mashima T., Fujita N., Yonehara S., Tsuruo T.: Chromosome 22 complements apoptosis in Fas- and TNF-resistant mutant UK110 cells. Oncogene, 13: 39-46, 199625. Matsuura S., Weemaes C., Smeets D., Takami H., Kondo N., Sakamoto S., Yano N., Nakamura A., Tauchi H., Endo S., Oshimura M., Komatsu K.: Genetic mapping using microcell-mediated chromosome transfer suggests a locus for Nijmegen breakage syndrome at chromosome 8q21-24. Am. J. Hum. Genet., 60: 1487-1494, 199726. Matsuura S., Tauchi H., Nakamura A., Kondo N., SakamotoS., Endo S., Smeets D., Solder B., Belohradsky B.H., Der Kaloustian V.M., Oshimura M., Isomura M., Nakamura Y., Komatsu K.: Positional cloning of the gene for Nijmegen breakage syndrome. Nature Genet., 19: 179-181, 199827. Kodama S., Kashino G., Suzuki K., Takatsuji T., Okumura Y., Oshimura M., Watanabe M., Barrett J.C.: No correction of abnormal phenotypes in Werner Syndrome cells by introduction of a normal human chromosome 81. Cancer Res., 58: 5188-5195, 199828. Errami A., He D.M., Friedl A.A., Overkamp W.J.I., Morolli B., Hendrickson E.A., Eckardt-Schupp F., Oshimura M., Lohman P.H.M., Jackson S.P., Zdzienicka M.Z.: XR-1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation. Nucl. Acids Res., 26: 3146-3153, 199829. Cui X., Brenneman M., Meyne J., Oshimura M., Goodwin E.H., Chen, D.J.: The XRCC2 and XRCC3 repair genes are required for chromsoome stability in mammalian cells. Mutat. Res., 434: 75-88, 199930. 栗政明弘,押村光雄 染色体工学を用いた細胞の放射線感受性に関わる遺伝子群の同定 癌の臨床,46:321-329, 200031. Sado K., Ayusawa D., Enomoto A., Suganuma T., Oshimura M., Sato K., Koyama H.: Identifi cation of a mutated DNA ligase IV gene in the X-ray-hypersensitive mutant SX10 of mouse FM3A cells. J. Biol. Chem., 276: 9742-9748, 200132. Horibata K., Iwamoto Y., Kuraoka I., Jaspers NG., Kurimasa A., Oshimura M., Ichihashi M., Tanaka K.: Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome. Proc Natl Acad Sci U S A., 26;101:15410-5, 200433. Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T, Kanazawa S, Koike J, Kikuchi Y, Zhong X, Arita M, Shibuya K, Oshimura M, Hemmi H, Boland CR, Koi M.: Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res., 68:8465-72. 200834. Ariyoshi K., Suzuki K., Goto M., Oshimura M., Ishizaki K., Watanabe M., Kodama S.: Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene. J Radiat Res (Tokyo). 50:253-9. 2009E: Senescence, telomere and telomerase(細胞老化、テロメア、テロメラーゼ)1. Sugawara O., Oshimura M., Koi M., Annab L.A., Barrett J.C.: Induction of cellular senescence in 157

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