鳥取大学における染色体医工学研究の歩み

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20. 押村光雄:細胞の個性を決めるエピジェネティクス 実験医学 20: 2184-2187, 200221. 香月康宏,吉岡広陽,春田雅之,押村光雄:発生・分化のキーメカニズムとしてのゲノムインプリンティング 実験医学 : 2219-2224, 200222. Feinberg A.P., Oshimura M., Barrett J.C.: Epigenetic mechanisms in human disease. Cancer Res., 62: 6784-6787, 200223. Jouvenot Y., Ginjala V., Zhang L., Liu P-Q., Oshimura M., Feinberg A.P., Wolffe A.P., Ohlsson R., Gregory P.D.: Targeted regulation of imprinted genes by synthetic zinc-fi nger transcription factors. Gene Therapy, 10: 513-522, 200324. 大槻明広,押村光雄:ゲノム刷り込みの異常と疾患 現代医療35: 1013-1018, 2003 25. Kashiwagi A., Meguro M., Hoshiya H., Haruta M., Ishino F., Shibahara T., Oshimura M.: Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb. J. Hum. Genet., 48: 194-198, 200326. Hoshiya H., Meguro M., Kashiwagi A., Okita C., Oshimura M.: Calcr, a brain-specifi c imprinted mouse calcitonin receptor gene in the imprinted cluster of proximal region of chromosome 6. J. Hum. Genet., 48: 208-211, 200327. Yu Y., Fujii S., Yuan J., Luo R.Z., Wang L., Bao J., Kaodta M., Oshimura M., Dent S.R., Issa J.P., Bast R.C.Jr.: Epigenetc regulation of ARHI in breast and ovarian cancer cells. Ann. N.Y. Acad. Sci., 983: 268-277, 200328. Nikaido I., Saito C., Mizuno Y., Meguro M., Bono H., Kadomura M., Kono T., Morris G.A., Lyons P.A., Oshimura M., RIKEN GER Group and GSL Members, Hayashizaki Y., Okazaki Y.: Discovery of imprinted transcripts in the mouse transcriptome using large-scale expression profi ling. Genome Res., 13: 1402-1408, 200329. Okita C., Meguro M., Hoshiya H., Haruta M., Sakamoto Y., Oshimura M.: A new imprinted cluster on the human chromosome 7q21-q31, identifi ed by human-mouse monochromosomal hybrids. Genomics, 81: 556-559, 200330. Fujii S., Luo R.Z., Yuan J., Kadota M., Oshimura M., Dent S.R., Kondo Y., Issa J-P.J., Bast R.C.Jr., Yu Y.: Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum. Mol. Genet., 12: 1791-1800, 200331. Yuan J., Luo R.Z., Fujii S., Wang L., Hu W., Andreeff M., Pan Y., Kadota M., Oshimura M., Sahin A.A., Issa J-P., Bast R.C.Jr., Yu Y.: Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancer. Cancer Res., 63: 4174-4180, 200332. 押村光雄:生命現象とエピジェネティクス 実験医学, 21:1495-1498, 200333. 目黒牧子,押村光雄:ゲノム刷り込み異常と疾患 実験医学, 21: 1552-1557, 200334. 押村光雄,今井浩三,牛島俊和:エピジェネティクスの診断への応用,治療への応用の可能性 現代医学 35: 908-924, 2003 35. Suda T., Katoh M., Hiratsuka M., Fujiwara M., Irizawa Y., Oshimura M.: Use of real-time RT-PCR for the detection of allelic expression of an imprinted gene. Intl. J. Mol. Med., 12:243-246, 200336. Higashimoto K., Urano T., Sugiura K., Yatsuki H., Joh K., Zhao W., Iwakawa M., Ohashi H., Oshimura M., Niikawa N., Mukai, T., Soejima H.: Loss of CpG methylation is strongly correlated with loss of histon H3 lysine 9 methylation at DMR-LIT1 in patients with Beckwith-Wiedemann syndrome. Am. J. Hum. Genet., 73: 948-956, 200337. 坂谷貴司,押村光雄:がんとエピジェネティクス 58:2125-2133, 200338. Yamada T., Mitsuya K., Kayashima T., Yamasaki K., Ohta T., Yoshiura K-I., Matsumoto N., Yamada H., Minakami H., Oshimura M., Niikawa M., Kishino T.: Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-fl anking region at human chromosome 7q32. Genomics, 83: 402-412, 200439. Hirota T., Ieiri I., Takane H., Maegawa S., Hosokawa M., Kobayashi K., Chiba K., Nanba E., Oshimura M., Sato T., Higuchi S., Otsubo K.: Allelic expression imbalance of the human CYP3A4 gene and 164

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