実績・論文など

【発表論文】

1) Osaki M, Inaba A, Nishikawa K, Sugimoto Y, Shomori K, Inoue T, Oshimura M, Ito H: Cysteine-rich protein 61 suppresses cell invasion via down-regulation of matrix metalloproteinase-7 expression in the human gastric carcinoma cell line MKN-45. Mol Med Rep 3(4): 711-715, 2010

2)    Takeshita F, Patrawala L, Osaki M, Takahashi R, Yamamoto Y, Kosaka N, Kawamata M, Kelnar K, Bader AG, Brown D, Ochiya T: Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther 18(1): 181-187, 2010

3)    Kazuki Y, Hiratsuka M, Takiguchi M, Osaki M, Kajitani N, Hoshiya H, Hiramatsu K, Yoshino T, Kazuki K, Ishihara C, Takehara S, Higaki K, Nakagawa M, Takahashi K, Yamanaka S, Oshimura M: Complete genetic correction of iPS cells from duchenne musclar dystrophy. Mol Ther 18(2): 386-393, 2010

4)    尾﨑充彦、落谷孝広: microRNA医薬によるがん治療への展開　−がん転移モデルに対するmiRNAの核酸医薬としての検証を中心に−　医学のあゆみ 238(5): 524-528, 2011

5)    Osaki M, Takeshita F, Sugimoto Y, Kosaka N, Yamamoto Y, Yoshioka Y, Kobayashi E, Yamada T, Kawai A, Inoue T, Ito H, Oshimura M, Ochiya T: MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression. Mol Ther 19(6): 1123-1130, 2011

6)    Kazuki Y, Hoshiya H, Takiguchi M, Abe S, Iida Y, Osaki M, Katoh M, Hiratsuka M, Shirayoshi Y, Hiramatsu K, Ueno E, Kajitani N, Yoshino T, Kazuki K, Ishihara C, Takehara S, Tsuji S, Ejima F, Toyoda A, Sakaki Y, Larionov V, Kouprina N, Oshimura M: Refined human artificial chromosome vectors for gene therapy and animal transgenesis. Gene Ther 18(4): 384-393, 2011

7)    Qi DL, Ohhira T, Fujisaki C, Inoue T, Ohta T, Osaki M, Ohshiro E, Seko T, Aoki S, Oshimura M, Kugoh H: Identification of PITX1 as a TERT suppressor gene located on human chromosome 5. Mol Cell Biol 31(8): 1624-1636, 2011

8)    Yasunaga M, Oumi N, Osaki M, Kazuki Y, Nakanishi T, Oshimura M, Sato K: Establishment and characterization of a transgenic mouse model for in vivo imaging of Bmp4 expression in the pancreas. PLoS One 6(9): e24956, 2011

9)    Hiratsuka M, Uno N, Ueda K, Kurosaki H, Imaoka N, Kazuki K, Ueno E, Akakura Y, Katoh M, Osaki M, Kazuki Y, Nakagawa M, Yamanaka S, Oshimura M: Integration-free iPS cells engineered using human artificial chromosome vectors. PLoS One 6(10): e25961, 2011

10)    Kakeda M, Nagata K, Osawa K, Matsuno H, Hiratsuka M, Sano A, Okazaki A, Shitara S, Nishikawa S, Masuya A, Hata T, Wako S, Osaki M, Kazuki Y, Oshimura M, Tomizuka K: A new chromosome 14-based human artificial chromosome (HAC) vector system for efficient transgene expression in human primary cells. Biochem Biophys Res Commun 415 (3): 439-444, 2011

11)    尾﨑充彦、杉本結衣：マイクロRNAによるがん転移予防への展開—miR-143による骨肉腫肺転移抑制効果とその標的遺伝子の同定—　遺伝子医学MOOK 23号: 151-156, 2012（編集担当）

12)    Kobayashi S, Kuwata K, Sugimoto T, Igarashi K, Osaki M, Okada F, Fujii J, Bannai S, Sato H: Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative stress-inducing agent paraquat. Free Radic Biol Med 53(12): 2197-2203, 2012

13)    Osaki M, Chinen H, Yoshida Y, Ohhira T, Sunamura N, Yamamoto O, Ito H, Oshimura M, Kugoh H: Decreased PITX1 gene expression in human cutaneous malignant melanoma and its clinicopathological significance. Eur J Dermatol 23(3) 344-349, 2013

14)    Yasunaga M, Masui E, Oji A, Soma A, Osaki M, Nakanishi T, Sato K: Identification of the control region of pancreatic expression of Bmp4 in vitro and in vivo. PLoS One 8(4) e61821, 2013

15)    Osaki M, Kosaka N, Okada F, Ochiya T: Circulating miRNAs in drug safety assessment for hepatic and cardiovascular toxicity: the latest biomarker frontier? Mol Diagn Ther 18(2), 121-126, 2014

16)    Kanda Y, Kawaguchi T, Kuramitsu Y, Kitagawa T, Kobayashi T, Takahashi N, Tazawa H, Habelhah H, Hamada J, Kobayashi M, Hirahata M, Onuma K, Osaki M, Nakamura K, Kitagawa T, HosokawaM, Okada F: Fascin Regulates Chronic Inflammation-related Human Colon Carcinogenesis by Inhibiting Cell Anoikis. Proteomics 14(9), 1031-1041 2014